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Application of saccinic acid in preparing antianxiety medicine

A technology of succinic acid and anti-anxiety, which is applied in the field of medicine to achieve the effect of good drug effect and good development and application prospects

Inactive Publication Date: 2002-09-18
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some anxiolytic preparations contain succinic acid or its salts or esters, they all appear as excipients with no pharmacological activity

Method used

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  • Application of saccinic acid in preparing antianxiety medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The following animal experiment proves that succinic acid has anxiolytic effect, but does not imply any limitation to the present invention.

[0009] 1. Mouse elevated plus labyrinth experiment

[0010] As experimental animals, male Kunming mice were used, 5 mice per cage, with free access to food and water. Reared in a 12-hour cycle reverse light-dark environment (lights off at 7:00 am) for at least 10 days. The mice weighed 18-22 grams during the experiment.

[0011] Succinic acid is prepared with distilled water, adjusted to pH 7.0 with sodium hydroxide, and administered by gavage.

[0012] The elevated cross labyrinth device (Pharmaco Biochem Behav, 1995, 52(4): 805) is made of plexiglass, 45 cm above the ground, including two 30 × 5 cm open arms and two 30 × 5 × 15 cm closed arms. arm. The bottom of the maze is all black plexiglass. The closed arm is transparent plexiglass except the bottom, and the upper part of the closed arm is open. There is a 5 × 5 cm op...

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PUM

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Abstract

The application of succinic acid in preparing antianxiety medicine is disclosed. The said succinic acid may also be the salt, ester, halide, or anhydride of succinic acid, and said medicines may be the form of tablet, capsule, solution, suspension, or injection. Its advantages are high curative effect and no by-effect.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to the application of succinic acid in the preparation of anti-anxiety drugs. Background technique: [0002] Benzodiazepines and their derivatives are the most frequently used drugs in anxiolytics. These drugs can reduce or eliminate symptoms such as irritability, nervousness, and terror in patients with anxiety disorders, but they also have side effects such as sedation, hypnosis, anticonvulsants, and muscle relaxation while being used for a long time. tolerance and dependence. The azaspirodecanedione anxiolytics represented by buspirone are a new type of anxiolytics in terms of chemical structure, pharmacological action and mechanism of action. This type of drug has no side effects such as sedation, hypnosis, muscle relaxation and anticonvulsion, and its effect is equivalent to that of diazepam, and long-term use does not produce tolerance and dependence. But there are side e...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61P25/22
Inventor 陈思维
Owner SHENYANG PHARMA UNIVERSITY