Niclosamide insecticide and molluscacide suspension and its prepn. process

A technology of niclosamide and suspending agent, applied in the field of suspending agent, can solve problems such as environmental pollution, achieve the effects of saving organic solvents, less investment in equipment, and facilitating popularization and promotion

Inactive Publication Date: 2003-01-08
JIANGSU PESTICIDE RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the dosage form of niclosamide developed in China is only 25% emulsifiable concentrate, 50% ethanolamine salt, and wettable powder of 70% ethanolamine salt, and its use causes pollution to the environment
There is no niclosamide suspension in the market so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The preparation method of the present invention is as follows:

[0022] Put the original drug of niclosamide, wetting agent, dispersing and suspending agent, thickening agent, antifreeze, preservative, defoaming agent and water into the bucket, and turn on the high-shear emulsifier to pulverize and mix to make it evenly mixed , the weight percentage of each composition is:

[0023] Niclosamide 10-50%

[0024] Wetting agent 0.2-5%

[0025] Dispersion suspending agent 0.5-10%

[0026] Preservatives 0.1-2%

[0027] Antifreeze 1-8%

[0028] Tackifier 0.1-3%

[0029] Defoamer 0-5%

[0030] water balance

[0031] The uniformly mixed materials are ground 1-2 times by a sand mill, and the product can be packaged after passing the quality inspection.

[0032] In the present invention, the former pesticide is niclosamide, and the structural formula is

[0033] Molecular formula is C 13 h 8 Cl 2 N 2 o 4 , the chemical...

example 1

[0043] The original drug niclosamide 10.2g, styrene polyoxyethylene ether condensate 3g, sodium dibutylsulfonate 5g, magnesium aluminum silicate 3g, ethylparaben 0.8g, glycerin 1.5g, silicone oil 0.8 g and 75.7 g of water were mixed evenly, and then entered into a sand mill for grinding until the fineness of the suspension reached the requirement (2-3u), and 10% niclosamide SC finished product was obtained.

example 2

[0045] The original drug niclosamide 23.1g, alkylphenol polyoxyethylene ether formaldehyde condensate 2.5g, sodium p-methyl fatty acid amidobenzene sulfonate 6g, sodium carboxymethylcellulose 2g, sodium salicylate 1g, propylene glycol 2g, 1.5g of XBE2000 and water (make up to 100) were mixed evenly, and sent to a sand mill for grinding until the fineness of the suspending agent reached the requirement, that is, 25% (W / V) niclosamide SC product was obtained.

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PUM

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Abstract

The present invention relates to a suspending agent formed from niclosamide as chemical active substance and several auxiliary materials and its preparation method. Its preparation method includes: using niclosamide as raw material medicine, adding moistening agent, dispersing and suspending aid, tack-producing agent, antifreezing agent, preservative, defoaming agent and water, uniformly mixing them, pulverizing by means of high shearing emulsifying machine in a barrel, grinding for once or at twice, and quality test and packaging so as to obtain the invented niclosamide pesticide spirillicide suspending agent.

Description

technical field [0001] The invention relates to a suspending agent which contains niclosamide as a chemically active substance and is composed of several auxiliary materials and a preparation method thereof. Background technique [0002] At present, the dosage form of niclosamide developed in China is only 25% emulsifiable concentrate, 50% ethanolamine salt, and wettable powder of 70% ethanolamine salt, and its use causes pollution to the environment. There is no niclosamide suspension in the market so far. Contents of the invention [0003] The object of the present invention is to propose a kind of niclosamide insecticide and molluscicide suspensible agent with simple and feasible process, less equipment investment and less environmental pollution and its preparation method. [0004] Technical solution of the present invention: [0005] A niclosamide insecticidal and mollusc-killing suspension is characterized in that it is mixed with niclosamide former drug, wetting a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/02A01N37/48
Inventor 徐年凤戴建荣张瑶梁幼生韩顺宁沈敏熊建民朱荫昌
Owner JIANGSU PESTICIDE RES INST
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