Method of treating skin conditions

A technology for improving skin and condition, applied in the fields of improving or treating disease states associated with PPAR upregulation, skin and other disease states, prevention, perilla seed oil, improving the health and aesthetics of affected skin and/or hair, Ability to address issues such as not revealing or pointing out the cosmetic appearance of the skin

Inactive Publication Date: 2003-04-16
AVON PROD INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Yenoda et al. patent does not indicate that perilla oil is an effective topical active ingredient for the prevention, amelioration or treatment of acne or non-disease conditions such as cosmetics, skin conditions
[0010] Thus, none of the prior art discloses or suggests that the use of a topical composition containing perilla oil in an effective dose can improve or treat acne and / or non-disease-state skin conditions (such as cellulite) associated with upregulation of PPAR regulatory pathways. Improves the cosmetic appearance of the skin

Method used

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  • Method of treating skin conditions
  • Method of treating skin conditions

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Experimental program
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Effect test

Embodiment 1

[0059] The effect of known PPAR agonists and compositions of the invention on PPAR upregulation in human skin cells was determined by measuring the relative activity of PPRE ("Peroxisome Proliferator Response Element"). Preconfluent keratinocytes were transiently transfected with PPRE-luciferase reporter constructs together with β-galactosidase. Four similar groups of cells were then treated for 24 hours. The first set consisted of media containing 0.05% dimethylsulfoxide (DMSO). The second group was treated with G3, a PPARα agonist. The third group was treated with A4 (perilla seed oil diluted 100 times with DMSO). The fourth group was treated with G3 and A4.

[0060] The results are shown in Figure 1, the addition of a PPAR agonist (G3) almost doubled the PPRE activity compared to the vehicle sample. Addition of perilla seed oil (A4) completely inhibited the upregulation of PPAR in the presence of G3. Example 2

Embodiment 2

[0061] Preconfluent keratinocytes were transfected with PPRE-luciferase and β-galactosidase as described in Example 1. Six similar groups of cells were then treated for 24 hours. The first group consisted of media containing 0.05% DMSO. The second group was treated with A5 (perilla seed oil diluted 100 times with DMSO). The third group was treated with farnesol, a PPAR activator. The fourth group was treated with farnesol and A5. A fifth group was treated with a clofibrate analog, a known agonist of PPARα. A sixth group was treated with the clofibrate analogue and A5. As shown in Figure 2, the addition of A5 to cells treated with PPAR agonist significantly inhibited the upregulation of PPAR. In fact, even in the presence of this stimulant, A5 was able to maintain the activity of PPRE in the range of vehicle alone.

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Abstract

The present invention is a method of treating skin or hair conditions, such as acne, blemishes, breakouts, cellulite, oily skin, oily hair, oily scalp, or any combination thereof, that comprises topically applying an effective amount of perilla oil to the affected area of the skin or hair. The topical application of perilla oil inhibits PPAR upregulation in skin cells, particularly PPARalpha upregulation.

Description

Background of the invention [0001] 1, field of invention [0002] The present invention relates to compositions for topical application and for preventing, ameliorating or treating diseases associated with the upregulation of skin cell genes due to the activation of peroxisome proliferator-activated receptor (hereinafter referred to as "PPAR", which is a protein) Approach to skin and other disease states. More specifically, the present invention relates to topical compositions and methods for preventing, ameliorating or treating disease states associated with upregulation of PPARs, such as acne and / or cellulite. [0003] 2, Description of related fields [0004] Although the role of PPARs in metabolic pathways is still under investigation, PPAR receptors are known to play an important role in the regulation of energy balance, especially in glucose and lipid metabolism. Furthermore, it is known that there is not only one type of PPAR, but rather a family or isomers of P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/36A61K8/67A61K8/92A61K36/534A61Q5/00A61Q19/00A61Q19/02A61Q19/06A61Q19/08
CPCA61K36/534A61K8/671A61K8/361A61Q19/06A61K8/67A61K8/342A61Q5/00A61Q5/008A61Q19/08A61K2800/70A61Q19/00A61K8/922A61Q19/008A61Q19/02A61P17/10
Inventor G·K·梅农
Owner AVON PROD INC
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