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Extraction method of notoginsenoside

A technology of Panax notoginseng saponins and an extraction method, applied in the field of extraction of Panax notoginseng saponins, can solve problems such as yield decline, product loss and the like, and achieve the effects of low production cost, stable quality and high content

Inactive Publication Date: 2003-04-30
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Each additional process in the extraction process of traditional Chinese medicine will cause a loss of about 5% of the product
Therefore it can be said that although the above two patented technologies have obtained a product with higher purity, it is at the cost of a decline in the yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 20 grams of Panax notoginseng is crushed, 80% concentration of ethanol aqueous solution is heat refluxed, after recovering ethanol from the extract, it is diluted with water to 100-120ml, and the clarified aqueous solution is filtered. The aqueous solution that obtains is passed into the resin post that ADS-2 resin is housed (column diameter 15mm, 50ml resin is housed), washes with the water of the pH=6 of 100ml, desorbs with the ethanol desorption of 200ml 50%, adsorption, washing, desorption The flow rate was 0.5 bed volume / hour. The desorbed solution was concentrated under reduced pressure, dried in vacuum and pulverized to obtain 1.72 g of a white powdery notoginseng saponin extract with a yield of 8.60%. Through the chromatographic analysis of Waters484 type high performance liquid chromatography, the result is: the product purity is ginsenoside Rg 1 31.7%, Re 5.40%, Rb 1 5.79% and Notoginsenoside R 1 21.7%.

Embodiment 2

[0026] 20 grams of Panax notoginseng is crushed, 80% concentration of ethanol aqueous solution is heat refluxed, after recovering ethanol from the extract, it is diluted with water to 100-120ml, and the clarified aqueous solution is filtered. Pass the obtained aqueous solution into the resin column (column diameter 15mm, 50ml resin is housed) that ADS-2 resin is housed, wash with the water of 100ml, desorb with the ethanol desorption of 200ml 70%, the flow velocity of adsorption, washing, desorption is 1 time Bed volume / hour. The desorbed solution was concentrated under reduced pressure, dried in vacuum and pulverized to obtain 1.62 g of a white powdery notoginseng saponin extract with a yield of 8.10%. Through the chromatographic analysis of Waters484 type high performance liquid chromatography, the result is: the product purity is ginsenoside Rg 1 31.1%, Re, 5.23%, Rb 1 5.42% and Notoginsenoside R 1 20.1%.

Embodiment 3

[0028]Crush 10kg of notoginseng, heat reflux with 80% ethanol aqueous solution, recover ethanol from the extract, add water to dilute to 60L, and filter to obtain a clarified aqueous solution. Pass the obtained aqueous solution into the resin column (column diameter 500mm, 20L resin is housed) that ADS-2 resin is housed, wash with 40L water, desorb with 100L 50% ethanol, the flow velocity of adsorption, washing, desorption is 1 time Bed volume / hour. The desorbed solution was concentrated under reduced pressure, dried in vacuum and pulverized to obtain 823 g of a white powdery notoginseng saponin extract with a yield of 8.23%. Through the chromatographic analysis of Waters484 type high performance liquid chromatography, the result is: the product purity is ginsenoside Rg 1 33.4%, Re 5.43%, Rb 1 5.22% and Notoginsenoside R 1 20.5%.

[0029] Sapoion

[0030] 3, 20-Diol-ginsenoside 3, 6, 20-t riol-ginsenoside

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Abstract

A process for extracting arasaponin from notoginseng features that the strong-polarity macroreticular adsorption resin and the "adsorption-desorption" technology are used.

Description

technical field [0001] The invention relates to the extraction and separation of effective components of traditional Chinese medicine, in particular to the extraction method of notoginseng saponins. The effective components of Panax notoginseng are separated and purified by using strong polar macroporous adsorption resin. The active component of Panax notoginseng saponin has the effects of removing stasis and stopping bleeding, promoting blood circulation and relieving pain, and can be used to treat cardiovascular and cerebrovascular diseases. Background technique [0002] The extraction and separation of active components of traditional Chinese medicine is a key step in realizing the modernization of traditional Chinese medicine. How to complete the extraction and separation of effective parts of traditional Chinese medicine on the basis of respecting the tradition of traditional Chinese medicine is also a problem that puzzles the majority of medical workers. Sanqi [Panacps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
Inventor 欧来良史作清施荣富王春红
Owner NANKAI UNIV
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