Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods

A dry powder inhaler, dry powder technology, applied in inhalers, drug devices, therapeutic insufflators, etc., can solve problems such as drug residues, the influence of stable powder distribution, and difficulty in reducing the amount of drugs

Inactive Publication Date: 2003-05-07
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the need to separate the drug from the excipients and the agglomeration of the drug particles, a greater inhalation action is required, which in turn affects the stable release of the powder in the patient's airway, making it difficult Reaching the desired attachment / target site and making it difficult to reduce the amount of drug that is prematurely attached elsewhere
[0009] Additionally, many dry powder inhalers can result in considerable drug residue remaining in the device, which can cause serious problems over time

Method used

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  • Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods
  • Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods
  • Dry powder inhaler devices, multi-dose dry powder drug packages, control systems, and associated methods

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Experimental program
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Embodiment

[0131] In an experimental DPI embodiment, a piezoelectric excitation element for vibrating the powder during dispensing was employed, the DPI having a structure such that the polymer film vibration element had an associated capacitance C greater than 1800 pf. This capacitance value is related to the size or area (and thus shape) of the capsule or vibrating element. The transformer used to boost the input voltage of 5Vp-p has an inductance of about 23mH on its second side. A transformer is used to step up the voltage to the capsule excitation voltage of 150Vp-p. In this way, the transformer and the piezoelectric element are combined to form an amplifier, and the resonant frequency of the amplifier can be expressed as the following equation:

[0132] f=1 / (2π(LC) 1 / 2 )

[0133] Among them, L is the inductance of the transformer, and C is the capacitance of the polymer film vibration element. This results in a calculated resonant frequency of about 25 kHz for the experimental ...

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Abstract

Dry powder inhalers (Picture 1) with integrated active energy patient assist dispersal systems are configured with control systems which provide adjustable energy output responsive to the user's inspiratory capabilities and / or the flowability of the dry powder being administered. The multi-dose dry drug package (Picture 2) a piezoelectric polymer substrate which flexes to deform and provide mechanical oscillation in a selected region of the package corresponding to the dry powder drug which is dispersed during inhalation by a user. Control system (Picture 12) employs fuzzy logic to relate in response to a user's inspiratory effort.

Description

technical field [0001] The present invention relates generally to drug delivery devices, and in particular to dose-adjusted dry powder inhalers. Background technique [0002] The delivery of medicaments in the form of inhaled aerosols is well known. In fact, asthma and other respiratory diseases have long been treated by inhaling aerosols. There is currently interest in the medical community to extend this delivery concept to locally acting agents such as antibacterials, protease inhibitors, nucleic acids / oligosaccharides, and systemically acting agents such as peptides such as leuprolide and proteins such as insulin. Examples of drugs that can be delivered using an inhaler are: antibacterials such as anti-tuberculosis synthetics, proteins such as insulin used to treat diabetes or other insulin-resistant diseases, peptides such as those used to treat prostate cancer and endometriosis leuprolide acetate for cystic fibrosis, and nucleic acids or oligonucleotides for the trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M13/00A61M15/00
CPCA61M2015/0048A61M2015/0051A61M2015/0005A61M15/0003A61M15/0048A61M15/0085A61M2015/0003A61M15/0051A61M2202/064A61M15/0045A61M15/0005A61M15/00
Inventor 安东尼·J·希基蒂莫西·M·克劳德
Owner THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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