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Improved stannous oral compositions

An oral composition and the technology of the composition are applied in the direction of drug combination, oral care, dentistry, etc., and can solve the problems of unacceptable astringency of the preparation, reduction of tooth staining, loss of antibacterial/anti-plaque activity, etc.

Inactive Publication Date: 2003-05-28
PROCTER & GAMBLE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The second common side effect is unacceptable astringency of the formulation
Therefore, in order to achieve stabilization and / or reduction in tooth staining, there may be a loss of antimicrobial / antiplaque activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0099] Example I is a two-phase dentifrice composition. Sodium polyphosphate (Glass H of FMC Corporation, n=21 unit condensed phosphate polymer) is included in the first dentifrice composition, stannous fluoride and other stannous Salt is included in the second dentifrice composition.

[0100] Ingredients

Formulation 1a

Formulation 2a

Formulation 3a

Formulation 4a

Carboxymethyl cellulose

0.500

0.200

0.200

0.300

Water

2.210

-

-

1.400

Flavor

1.500

1.100

1.100

1.100

Glycerin

29.890

45.550

43.550

39.850

Polyethylene glycol

1.500

-

-

6.000

Polyethylene oxide

0.200

-

-

-

Propylene Glycol

8.000

-

-

-

Sodium dodecyl sulfate (a)

10.000

8.000

10.00...

Embodiment II

[0110] Example II is a single-phase dentifrice composition, including stannous salt, Glass H polyphosphate or polyphosphonate suspension and different fluoride ion sources, formulated with low water bottom materials to ensure the polymerization of MSA and stannous ions stability. Another example is the stannous dentifrice described in US Patent 5,004,594 by Majeti et al.

preparation Embodiment II

[0111] The compositions of Example II (formulations A-D) were prepared as follows: glycerin and thickener were added to the main mixing tank and mixed. If possible, add sodium gluconate to it and mix well. Add sodium lauryl sulfate solution and flavor, and stir until the thickener is hydrated / dissolved. Add silicon dioxide and titanium dioxide and mix well. Add stannous and / or fluoride salt and mix well. Finally, add polymer surfactant (Glass H or polyphosphonate) and mix well.

[0112] Ingredients

Formulation A

Formulation B

Formulation C

Formulation D

Comparative example

Flavor

1.00

1.200

1.500

1.150

1.000

Glycerin

53.166

54.300

52.872

9.000

14.425

Poloxamer 407

5.000

3.000

8.000

-

-

Stannous chloride

0.680

-

-

1.500

1.500

Tin sulfate

-

1...

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PUM

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Abstract

The present invention relates to oral compositions comprising a stannous ion source, a fluoride ion source, and a polymeric mineral surface active agent that binds stannous, said compositions providing adequate therapeutic efficacy with minimal side effects of tooth staining and astringency. The composition simultaneously provides reduction and control of supragingival calculus. The present oral care compositions may be formulated as single phase or dual phase compositions. The present invention also provides a method for effective delivery of stannous-containing compositions with minimal side effects of tooth staining or astringency and with effective tartar control by administering to a subject a stable dentifrice composition comprising a clinically effective amount of stannous fluoride and / or other stannous salts in combination with a fluoride ion source and a polymeric mineral surface active agent, preferably a phosphate- or phosphonate-containing polymer.

Description

[0001] This application claims the priority of U.S. Provisional Application 60 / 165350 dated November 12, 1999. Technical field [0002] The present invention relates to an improved oral composition containing stannous salts such as stannous fluoride. Such improved oral compositions can provide many oral effects based on stannous fluoride and / or other stannous salts, including antibacterial effects, improving breath, controlling plaque growth and metabolism, reducing gingivitis, and preventing periodontal disease. Develop, reduce tooth hypersensitivity, reduce crown and root caries. The above effects of this type of improved composition are significantly improved compared with traditional stannous compositions, including: 1) reducing tooth stains; 2) reducing astringency and improving the sensory quality of the composition; and 3) reducing dental plaque (dental calculus). The above effects of the stannous composition of the present invention are mainly deriv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/19A61K8/21A61K8/24A61K8/25A61K8/29A61K8/34A61K8/36A61K8/365A61K8/40A61K8/72A61K8/73A61K8/81A61K8/90A61Q11/00
CPCA61K8/81A61K8/8147A61K8/19A61K8/731A61K2800/88A61K8/24A61Q11/00A61K8/90A61K8/365A61K8/21A61K8/73A61P1/02
Inventor W·M·格兰多尔夫L·A·巴卡D·J·小怀特H·J·巴谢尔
Owner PROCTER & GAMBLE CO
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