Unlock instant, AI-driven research and patent intelligence for your innovation.

Fluconazole oral tablet capable of quickly disintegrating and dissolving out and preparation process

A fluconazole oral tablet and disintegrating agent technology, applied in the field of pharmaceutical preparations and its preparation, can solve the problems of poor water solubility of fluconazole, slow disintegration, inconvenient taking of capsules or tablets, etc.

Inactive Publication Date: 2003-08-27
HONGYI SCI & TECH CO LTD NANCHANG
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] However, in some patients with Candida infection of oral cavity, pharynx, and esophageal mucosa, it is inconvenient to take capsules or tablets because some patients have difficulty swallowing, and fluconazole has poor water solubility, slow disintegration, low dissolution rate and low bioavailability , affecting the full play of the therapeutic effect of fluconazole

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0058] Fluconazole 50g

[0059] Lactose 75g

[0060] Micronized silica gel 30g

[0061] Microcrystalline Cellulose 95g

[0062] Cross-linked polyvinylpyrrolidone 20g

[0063] Croscarmellose Sodium 25g

[0064] Stevia 4g

[0065] Poloxamer 2g

[0066] 30% ethanol solution 300ml

[0067] Magnesium Stearate 1g

[0068] Makes 1000 pieces

example 2

[0070] Fluconazole 50g

[0071] Lactose 75g

[0072] Micronized silica gel 30g

[0073] Microcrystalline Cellulose 95g

[0074] Cross-linked polyvinylpyrrolidone 20g

[0075] Croscarmellose Sodium 25g

[0076] Stevia 4g

[0077] 30% ethanol solution 300ml

[0078] Magnesium Stearate 1g

[0079] Makes 1000 pieces

example 3

[0081] Fluconazole 50g

[0082] Lactose 50g

[0083] Micronized silica gel 15g

[0084] Microcrystalline Cellulose 45g

[0085] Cross-linked polyvinylpyrrolidone 10g

[0086] Croscarmellose Sodium 25g

[0087] Stevia 3g

[0088] Tween-80 1g

[0089] 30% ethanol solution 200ml

[0090] Magnesium Stearate 1g

[0091] Makes 1000 pieces

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a fluconazole oral tablet which can be quickly disintegrated and resolved and its preparation process. Said preparation is made up by using (by weight portion) 1 portion of fluconazole as raw material medicine, 0.0-0.6 portion of disintegration adjuvant, 0.2-0.5 portion of disintegrating agent, 0.0-0.04 portion of surfactant, 0.9-1.9 portions of adhesive and 1.0-1.5 portions of solubilizing agent as auxiliary material through a certain preparation process. Said preparation can be quickly expanded, dispersed and making fluzonazole quickly resolved in the water to greatly raise the resolution of medicine and its biological utilization rate and can more effectively produce action for curing mycotic infection.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation process thereof, in particular to a fluconazole oral tablet capable of rapid disintegration and dissolution and a preparation process thereof. technical background [0002] Deep mycoses are very harmful and can often lead to death. Especially in recent years, the widespread use of broad-spectrum antibiotics, the destruction of the normal flora relationship between bacteria and fungi, the extensive use of corticosteroids, immunosuppressants, and anti-tumor drugs, the widespread use of organ transplantation and catheterization, some Immunodeficiency diseases, especially the emergence of AIDS, etc., and the extensive use of immunosuppressants will reduce the body's resistance to fungi, and increase the incidence and severity of deep fungal diseases. Malnutrition, infirmity, etc. are also susceptible to fungi Therefore, there is an urgent clinical need for anti-deep fungal drugs with ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4196A61P31/10
Inventor 刘智钱进许军彭红朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG