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Kit for diagnosing early nasopharyngeal carsinoma

An early diagnosis and kit technology, applied in biological testing, material testing products, measuring devices, etc., can solve the problems of inconspicuous, cumbersome, and difficult to detect early symptoms of nasopharyngeal cancer

Inactive Publication Date: 2003-10-01
SUN YAT SEN UNIV CANCER CENT
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, the early symptoms of nasopharyngeal carcinoma are not obvious, the primary site is hidden, difficult to find, and the course of the disease develops rapidly. In the past 30 years, immunohistochemical methods have been used in clinical and on-site inspections, which is subjective, time-consuming, eye-consuming and cumbersome.

Method used

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  • Kit for diagnosing early nasopharyngeal carsinoma
  • Kit for diagnosing early nasopharyngeal carsinoma
  • Kit for diagnosing early nasopharyngeal carsinoma

Examples

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Embodiment Construction

[0011] refer to figure 1 As shown, the present invention consists of 2 lyophilized solid-phase capture antigen plates (1), 2 anti-human IgA antibody plates (2), 2 benzidine diamine plates (3) and a saliva collector (4), The capture antigen plate (1) contains a short peptide that is a transactivator protein: AGRSTRKQARQERF, the amount is 40ug / block, it is coated on a solid surface (solid phase), the amount of the anti-human IgA antibody plate (2) is 1.5uL / block, and the amount of benzidine plate (3) is 6.7mg / block.

[0012] 211 (cases) of serum samples and 159 (cases) of saliva from patients with nasopharyngeal carcinoma diagnosed clinically and pathologically by the peptide chain on the capture antigen plate; 209 parts of saliva (example); and the serum and saliva samples of the same subject from the high-risk on-site population of nasopharyngeal carcinoma, each 393 parts (example) of detection verification (results are shown in the attached table and figure 2 ). Table 1 E...

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Abstract

A reagent kit for early diagnosis of nasopharyngeal carcinoma is composed of 2-4 freeze-dried solid-phase antigen plates 2-4 human IgA plates, 2-4 diphenyldiamine plates, and saliva collector.

Description

[technical field] [0001] The invention relates to a molecular-level diagnostic kit based on the biological characteristics of the Epstein-Barr virus antigen related to nasopharyngeal carcinoma. And quick useful tool. [Background technique] [0002] Epstein-Barr Virus (EBV) is common in our population, because EBV has multiple structures and specific antigens, including capsid antigen (VCA), early antigen (EA), nuclear antigen (EBNA) and membrane antigen (MA). etc. In different diseases related to EBV, different reactive antibodies appear, and these different antibody response patterns reflect the status of EBV acute, chronic, convalescence, persistent infection or past infection. Detection of corresponding antibody responses to these antigens is helpful in the diagnosis and treatment of diseases. [0003] It has been recognized that EBV is one of the important causes of nasopharyngeal carcinoma. A large number of studies have confirmed that the increase of EBV-IgA antibody...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N33/571G01N33/574
Inventor 汪慧民李满枝李端简少文刘庆伦郑美莲张玲
Owner SUN YAT SEN UNIV CANCER CENT
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