Total alkaloid composition from plant and its pharmaceutical preparation

A technology of total alkaloids and plant sources, applied in the field of plant source total alkaloid compositions

Inactive Publication Date: 2003-11-26
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching the FDA pharmaceutical resource information by active ingredients, no records can be found. Therefore, it can be considered that there are currently no Bo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Take 1kg of Bo Luohui medicinal materials, cut them into 1-2cm pieces, add 8 liters of water to soak, adjust the pH of the solution to 2.0-3.0 with hydrochloric acid, stir frequently, soak for 16-24 hours, and filter by pressure to obtain 5 liters of extract; 5 liters of aqueous solution with a pH of 2.0-3.0 were soaked for 16 hours, and filtered to obtain 5 liters of extract. Combine the two extracts, add concentrated NaOH solution, adjust the pH of the extract to 6.0-7.0, let stand overnight to precipitate the alkaloids; filter and collect the filtrate; add NaOH solution to the filtrate to adjust the pH of the filtrate to 9.0-9.5 , and add NaCl, make the NaCl concentration in the filtrate reach 3.8%, stir to make NaCl dissolve completely, leave standstill overnight, make alkaloid precipitation; filter and collect precipitation, obtain the total alkaloid precipitate of plant origin of the present invention, yield (with Constant weight product) is 1.5%, after testing, c...

Embodiment 2

[0077] Take 2kg of medicinal materials, cut them into 1-2cm pieces, put them into the extraction container, add 8 liters of methanol, then add 8g of citric acid and 8ml of hydrochloric acid into the extraction container, soak for 16-24 hours, and filter with suction. Extract 5 liters; add 5 liters of methanol to the container, supplement 5 g of citric acid, 5 ml of hydrochloric acid, soak for 8-12 hours, and filter with suction to obtain 5 liters of extract. Combine the two extracts, adjust the pH to 6.0-7.0 with concentrated alkali, let stand overnight to precipitate the alkaloids; filter and collect the filtrate; continue to adjust the pH of the filtrate to 9.0-9.5 with concentrated alkali, and add 30% chlorine The zinc chloride solution is dissolved to make the concentration of zinc chloride in the filtrate reach 2%-4%, and the alkaloids are allowed to settle overnight to precipitate the alkaloids, and the precipitates are collected by filtration to obtain the total alkaloid...

Embodiment 3

[0081] Take 1kg of blood and water herbs, cut them into 1-2cm pieces, add 8 liters of water to soak, adjust the pH of the solution to 2.0-3.0 with hydrochloric acid, stir frequently, soak for 16-24 hours, filter by pressure, and get 5 liters of extract; add 5 liters to the filter residue. The solution was soaked in an aqueous solution with a pH of 2.0-3.0 for 16 hours, and filtered to obtain 5 liters of extract. Combine the two extracts, add concentrated Na 2 CO 3 solution, adjust the pH of the extract to 6.0-7.0, let stand overnight to precipitate the alkaloids; filter, collect the filtrate; add Na to the filtrate 2 CO 3 solution, adjust the pH of the filtrate to 9.0-9.5, and add NaCl to make the NaCl concentration in the filtrate reach 3.8%, stir to completely dissolve the NaCl, let stand overnight to precipitate the alkaloids; filter and collect the precipitate to obtain the total organisms derived from the plants of the present invention. Alkali precipitate, the yield (...

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PUM

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Abstract

The present invention discloses a total alkaloid composite from plant has anticancer activity and its extraction process and use as well as medicine preparation containing the composite and its preparation process. The plant is macleaya cordata, greater celandine herb, adnate elder herb or Asiatic toddalia root. Experiment shows that the preparation has powerful effect of suppressing MRP gene expression and excellent effect of suppressing Ara-C to induce the expression of MDRI, and excellent anticancer effect.

Description

[0001] The technical field to which the invention belongs [0002] The present invention relates to a plant-derived total alkaloid composition with anti-cancer activity, an extraction method and use thereof, a pharmaceutical preparation comprising the composition and a preparation method thereof, wherein the plant is selected from the group consisting of Bo Luohui, celandine, blood water grass or Dragon palm blood. Background technique [0003] Alkaloid is one of the main medicinal active ingredients in many plants, and it is also one of the important contents of current Chinese medicine research. [0004] Bo Luohui, celandine, blood water grass, and dragon palm blood are botanical medicines that have not been listed in the Pharmacopoeia of the People's Republic of China. Among them, Bo Luohui, celandine, and blood water grass all belong to the family Papaveraceae, and their scientific names are Macleayacordata (Willd.) R.Br., Chelidonium majus L., Eomecon chionantha Hance, a...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61P35/00
Inventor 张平
Owner 张平
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