4-de-dimethyltetracycline derivative use

A technology of dimethylaminotetracycline and derivatives, applied in the direction of tetracycline active ingredients, drug combinations, and resistance to vector-borne diseases, etc., to achieve far-reaching medical research significance and huge commercial potential.
CN1470242AInactive Publication Date: 2004-01-28ๅˆ˜่ช‰
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
ๅˆ˜่ช‰
Publication Date
2004-01-28
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention refers to the application of 4-deminocycline ramification to the preparation of drugs of anti-SARS, antivirus, anti-leptospira, anti-mycobacterium, etc; a medicinal combination for curing SARS contains effective amount of 4-deminocycline ramification and medicinal carrier; the invention has the application advantage of 4-deminocycline ramification able to prevent and cure the infection caused by virus ( SARS coronary virus), leptospira and mycobacterium (including mycoplasma and chlamydia).
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Description

technical field

[0001] The invention relates to the application of a 4-dedimethylaminotetracycline derivative. Background technique

[0002] Tetracyclines (Tetracyclines) are found to be broad-spectrum bacteriostatic drugs (that is, they can inhibit the growth of Gram-positive and negative bacteria, but cannot kill bacteria), and are antibacterial drugs produced by bacteria Streptomyces aureofaciens, the main antibacterial effect by inhibiting bacterial protein synthesis. The mechanism of its antibacterial action is: the tetracycline molecule enters the bacteria and binds to the small subunit (ie 30S subunit) of the bacterial ribosome, which directly affects the recognition and pairing between the anticodon of the aminoacyl-tRNA and the codon of the mRNA, As a result, protein synthesis in bacteria is prevented, causing bacteria to stop growing and multiplying. Under the action of the immune system in the human body, the bacteria that have stopped growing can be eliminated ...

Claims

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