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4-de-dimethyltetracycline derivative use

A technology of dimethylaminotetracycline and derivatives, applied in the direction of tetracycline active ingredients, drug combinations, and resistance to vector-borne diseases, etc., to achieve far-reaching medical research significance and huge commercial potential.

Inactive Publication Date: 2004-01-28
刘誉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, very toxic second-line drugs (eg, rifampin) must be used for some drug-resistant forms of TB

Method used

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  • 4-de-dimethyltetracycline derivative use
  • 4-de-dimethyltetracycline derivative use
  • 4-de-dimethyltetracycline derivative use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] When used for external use, it contains 0.01% of the effective drug dose and 99.99% of the fat-soluble medium vaseline, and it is made by conventional technology for external use to achieve anti-virus, anti-spirochete and anti-mycobacterium effects.

Embodiment 2

[0050] When used for external use, it contains 5% of effective drug dose and 95% of glyceryl stearate as a fat-soluble medium. It is made by conventional technology for external use to achieve anti-virus, anti-spirochete and anti-mycobacterium effects.

Embodiment 3

[0052] When used for external use, it contains 0.05% effective drug dose and 99.95% sodium lauryl sulfate as a fat-soluble medium. It is made by conventional technology for external use to achieve anti-virus, anti-spiral and anti-mycobacterium effects.

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PUM

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Abstract

The invention refers to the application of 4-deminocycline ramification to the preparation of drugs of anti-SARS, antivirus, anti-leptospira, anti-mycobacterium, etc; a medicinal combination for curing SARS contains effective amount of 4-deminocycline ramification and medicinal carrier; the invention has the application advantage of 4-deminocycline ramification able to prevent and cure the infection caused by virus ( SARS coronary virus), leptospira and mycobacterium (including mycoplasma and chlamydia).

Description

technical field [0001] The invention relates to the application of a 4-dedimethylaminotetracycline derivative. Background technique [0002] Tetracyclines (Tetracyclines) are found to be broad-spectrum bacteriostatic drugs (that is, they can inhibit the growth of Gram-positive and negative bacteria, but cannot kill bacteria), and are antibacterial drugs produced by bacteria Streptomyces aureofaciens, the main antibacterial effect by inhibiting bacterial protein synthesis. The mechanism of its antibacterial action is: the tetracycline molecule enters the bacteria and binds to the small subunit (ie 30S subunit) of the bacterial ribosome, which directly affects the recognition and pairing between the anticodon of the aminoacyl-tRNA and the codon of the mRNA, As a result, protein synthesis in bacteria is prevented, causing bacteria to stop growing and multiplying. Under the action of the immune system in the human body, the bacteria that have stopped growing can be eliminated ...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61P11/00A61P17/04A61P31/00A61P31/12A61P31/14
CPCY02A50/30
Inventor 刘誉
Owner 刘誉
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