Use and medicine of 4-dedimethylamino tetracycline and its derivative in treating skin diseases
A technology of dimethylaminotetracycline and dimethylaminotetracycline, applied in the field of medicines containing 4-dedimethylaminotetracycline and/or its derivatives, capable of solving undisclosed derivatives of 4-dedimethylaminotetracyclines , no disclosure and other issues, to achieve the effect of inhibiting pathogens, inhibiting inflammatory reactions or allergic reactions, and efficient prevention and control methods
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Embodiment 1
[0062] Example 1 Preparation of 4-desdimethylaminotetracycline and its derivatives ointment
[0063] Select one or more of 4-desdimethylaminotetracycline, 4-desdimethylamino-6-desmethyl-6-dehydroxytetracycline and 4-desdimethylaminodoxycycline, grind it finely, Heat and melt vaseline, then mix 4-desdimethylaminotetracycline and its derivatives with vaseline at a ratio of 1:20 to make an ointment.
Embodiment 2
[0064] Example 2 Preparation of 4-dedimethylaminotetracycline and its derivative paint
[0065] Select one or more of 4-desdimethylaminotetracycline, 4-desdimethylamino-6-desmethyl-6-dehydroxytetracycline and 4-desdimethylaminodoxycycline, and combine it with phospholipids Mix well at a ratio of 50:1, add water to make an aqueous solution, and make a paint. This lotion can be used topically or rinsed off the affected area.
[0066] Pharmacological and Toxicological Experiments of 4-Desdimethylaminotetracycline and Its Derivatives
[0067] 4-Desdimethylaminotetracycline and 4-Desdimethylaminotetracycline and its derivatives 4-Desdimethylamino-6-Desmethyl-6-Deshydroxytetracycline, 4-Desdimethylaminochlorotetracycline, 4-Desdimethylaminooxytetracycline and 4-Desdimethylaminodoxycycline has been subjected to pharmacokinetic experiments (rats) and cytotoxicity experiments. The experimental results show that the pharmacological and toxicological properties of these drugs meet the...
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