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Use and medicine of 4-dedimethylamino tetracycline and its derivative in treating skin diseases

A technology of dimethylaminotetracycline and dimethylaminotetracycline, applied in the field of medicines containing 4-dedimethylaminotetracycline and/or its derivatives, capable of solving undisclosed derivatives of 4-dedimethylaminotetracyclines , no disclosure and other issues, to achieve the effect of inhibiting pathogens, inhibiting inflammatory reactions or allergic reactions, and efficient prevention and control methods

Inactive Publication Date: 2005-04-27
刘誉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 4-dedimethylaminotetracycline compounds include many compounds, and the patent application does not disclose whether the derivatives of 4-dedimethylaminotetracyclines can be used for the treatment of eczema dermatitis and other pruritic inflammatory skin diseases. It is not disclosed that derivatives of those 4-dedimethylaminotetracyclines can be used for the preparation of medicines for treating eczema dermatitis and other pruritic inflammatory skin diseases

Method used

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  • Use and medicine of 4-dedimethylamino tetracycline and its derivative in treating skin diseases
  • Use and medicine of 4-dedimethylamino tetracycline and its derivative in treating skin diseases
  • Use and medicine of 4-dedimethylamino tetracycline and its derivative in treating skin diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0062] Example 1 Preparation of 4-desdimethylaminotetracycline and its derivatives ointment

[0063] Select one or more of 4-desdimethylaminotetracycline, 4-desdimethylamino-6-desmethyl-6-dehydroxytetracycline and 4-desdimethylaminodoxycycline, grind it finely, Heat and melt vaseline, then mix 4-desdimethylaminotetracycline and its derivatives with vaseline at a ratio of 1:20 to make an ointment.

Embodiment 2

[0064] Example 2 Preparation of 4-dedimethylaminotetracycline and its derivative paint

[0065] Select one or more of 4-desdimethylaminotetracycline, 4-desdimethylamino-6-desmethyl-6-dehydroxytetracycline and 4-desdimethylaminodoxycycline, and combine it with phospholipids Mix well at a ratio of 50:1, add water to make an aqueous solution, and make a paint. This lotion can be used topically or rinsed off the affected area.

[0066] Pharmacological and Toxicological Experiments of 4-Desdimethylaminotetracycline and Its Derivatives

[0067] 4-Desdimethylaminotetracycline and 4-Desdimethylaminotetracycline and its derivatives 4-Desdimethylamino-6-Desmethyl-6-Deshydroxytetracycline, 4-Desdimethylaminochlorotetracycline, 4-Desdimethylaminooxytetracycline and 4-Desdimethylaminodoxycycline has been subjected to pharmacokinetic experiments (rats) and cytotoxicity experiments. The experimental results show that the pharmacological and toxicological properties of these drugs meet the...

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Abstract

The present invention is the use of 4-dedimethylamino tetracycline and its derivative in preparing medicine for treating eczema, dermatitis, pruritus and other skin diseases. The present invention also provides medicine for treating eczema, dermatitis, pruritus and other skin diseases. The medicine may be ointment, liniment, gel preparation, aerosol, tablet or capsule. The 4-dedimethylamino tetracycline and its derivative has no drug resistance, and the medicine with antiphlogistic and metalloprotease resisting effect is used to treat eczema, dermatitis, pruritus and other skin diseases.

Description

technical field [0001] The invention relates to the use of 4-desdimethylaminotetracycline and / or its derivatives in the preparation and treatment of eczema dermatitis and other pruritic inflammatory skin diseases. [0002] The invention also relates to a medicine containing 4-desdimethylaminotetracycline and / or its derivatives for treating eczema dermatitis and other pruritic inflammatory skin diseases. Background technique [0003] Tetracyclines (Tetracyclines) are broad-spectrum antibacterial drugs produced by bacteria Streptomyce-saureofaciens. The main antibacterial effect is achieved by inhibiting bacterial protein synthesis. The mother nucleus (tetracyclic structure) of tetracycline has strong fat solubility, which is necessary for this type of drug to enter bacterial cells and bind to target components in bacterial cells. Each group on the tetracycline core has different contributions to the antibacterial effect, among which 4-dimethylamino (the fourth -N(CH3)2 group...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61P17/00A61P17/04
Inventor 张宏蒋建伟
Owner 刘誉
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