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Injection medication combination of nimodipine and its preparing method

A technology of nimodipine and its composition, which is applied in the field of nimodipine injection pharmaceutical composition and its preparation, can solve problems such as unsatisfactory solubilization effect, and achieve industrial production convenience, simple quality control, and increased stability Effect

Inactive Publication Date: 2004-03-10
BEIJING SIHUAN KEBAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although both have a certain solubilizing effect on nimodipine, neither can achieve a satisfactory solubilizing effect when used alone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Nimodipine 2mg

[0033] Propylene glycol 350mg

[0034] Tween-80 50mg

[0035] Mannitol 200mg

[0036] Water for injection to 3ml

[0037] According to the method of appendix IX A of "Chinese Pharmacopoeia 2000 Edition (Part II)", place it in a Nessler colorimetric tube, and inspect it under fluorescent light. Compared with water, it is clear and transparent, not deeper than No. 1 turbidimetric solution.

Embodiment 2

[0039] Nimodipine 2mg

[0040] Propylene glycol 350mg

[0041] Tween-80 30mg

[0042] Mannitol 250mg

[0043] Water for injection to 3ml

[0044] According to the method of appendix IX A of "Chinese Pharmacopoeia 2000 Edition (Part II)", place it in a Nessler colorimetric tube, and inspect it under fluorescent light. Compared with water, it is clear and transparent, not deeper than No. 1 turbidimetric solution.

Embodiment 3

[0046] Nimodipine 2mg

[0047] Propylene Glycol 400mg

[0048] Tween-80 50mg

[0049] Mannitol 300mg

[0050] Water for injection to 2.5ml

[0051] According to the method of appendix IX A of "Chinese Pharmacopoeia 2000 Edition (Part II)", place it in a Nessler colorimetric tube, and inspect it under fluorescent light. Compared with water, it is clear and transparent, not deeper than No. 1 turbidimetric solution.

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PUM

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Abstract

A composite injection of nimodipine in the form of liquid injection or freeze dried powder is prepared from nimodipine and propanediol and tween kind of surfactant. Its advantage is high solubility. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical preparation of nimodipine for injection and a preparation method thereof. Background technique [0002] Nimodipine is a second-generation 1,4-dihydropyridine calcium channel blocker with the chemical name (±) isopropyl-2-methoxyethyl-1,4-dihydro-2,6-dimethyl Base-4(3-nitrophenyl)-3,5-piperidinedicarboxylate. Molecular formula is C 21 h 26 N 2 o 2 , the molecular weight is 418.45. It has anti-vasoconstriction and anti-ischemic effects on the brain. Nimodipine can prevent or eliminate various vasoactive substances (such as 5-hydroxytryptamine, prostaglandin and histamine) or blood and its degradation products. Modipine also has neurological and psychopharmacological properties. Studies on patients with acute cerebral blood supply disorders have shown that nimodipine can expand cerebral blood vessels and improve cerebral blood supply, and the increase in perfusion to brain damage and insufficient perfusion ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K31/4422A61K47/10A61P9/10A61P9/12
Inventor 张建强张建立盛爱武曹相林吴亚录张建勋
Owner BEIJING SIHUAN KEBAO PHARM CO LTD
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