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Skin penetrating paste containing ligustrazine free alkali and its preparation

A technology of transdermal patch and ligustrazine, which is applied in the field of transdermal patch containing ligustrazine free base and its preparation, can solve the inconvenience of patients and medical staff, and achieve clear curative effect, stable quality and good safety Effect

Inactive Publication Date: 2004-07-07
FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned route of administration or method of administration brings inconvenience and misery to patients and medical staff, so it is necessary to develop new dosage forms of ligustrazine to improve the compliance of patients for treatment

Method used

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  • Skin penetrating paste containing ligustrazine free alkali and its preparation
  • Skin penetrating paste containing ligustrazine free alkali and its preparation
  • Skin penetrating paste containing ligustrazine free alkali and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Repository prescription (1000 stickers):

[0093] Ligustrazine Phosphate 300g

[0094] Hydroxyethyl Cellulose 50g

[0095] Appropriate amount of sodium hydroxide

[0096] Ethanol 25ml

[0097] Eucalyptus oil 30ml

[0098] Add water to 1000g

[0099] Preparation Process:

[0100]Add hydroxyethyl cellulose to water and mix well, let stand to fully swell, then add prescription amount of ligustrazine phosphate, adjust pH to 7 with 15% NaOH solution, and form a gel. After mixing the ethanol and eucalyptus oil, slowly add them into the above-mentioned gel under stirring, and continue stirring until uniform, that is, the preparation of the gel reservoir is completed. Spread the silicone pressure-sensitive adhesive evenly on the EVA film, dry it, and cover it with a fluorocarbon-treated polyester protective layer after cooling. Quantitatively inject the gel reservoir onto the EVA controlled-release membrane, cover with a backing layer, heat-press and seal, and die-cut to...

Embodiment 2

[0102] Repository prescription (1000 stickers):

[0103] Ligustrazine 80g

[0104] Carbomer 20g

[0105] Appropriate amount of triethanolamine

[0106] Ethanol 100ml

[0107] Maple oil 50ml

[0108] Add water to 1000g

[0109] Preparation Process:

[0110] Add carbomer to half of the prescribed amount of water and mix well, let it stand to fully swell, then add the prescribed amount of ligustrazine, and adjust the pH to 7 with triethanolamine to form a gel. After mixing the ethanol and sweetgum oil, slowly add them into the above-mentioned gel under stirring, and continue stirring until uniform, that is, the preparation of the gel reservoir is completed. Spread the silicone pressure-sensitive adhesive evenly on the EVA film, dry it, and cover it with a fluorocarbon-treated polyester protective layer after cooling. Quantitatively inject the gel reservoir onto the EVA controlled-release membrane, cover with a backing layer, heat-press and seal, and die-cut to obtain the l...

Embodiment 3

[0112] Repository recipe (1000 stickers)

[0113] Ligustrazine 200g

[0114] Carbomer 20g

[0115] Appropriate amount of triethanolamine

[0116] Ethanol 20ml

[0117] Menthol 10g

[0118] Add water to 1000g

[0119] Preparation Process:

[0120] Add carbomer to half of the prescribed amount of water and mix well, let it stand to fully swell, then add the prescribed amount of ligustrazine, and adjust the pH to 7 with triethanolamine to form a gel. After dissolving menthol with ethanol, slowly add it into the above-mentioned gel under stirring, and continue stirring until uniform, that is, the preparation of the gel reservoir is completed. Spread the silicone pressure-sensitive adhesive evenly on the EVA film, dry it, and cover it with a fluorocarbon-treated polyester protective layer after cooling. Quantitatively inject the gel reservoir onto the EVA controlled-release membrane, cover with a backing layer, heat-press and seal, and die-cut to obtain the ligustrazine tran...

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Abstract

A percutaneous picking of liquestrazine free alkali for preventing thrombocyte coagulation, expanding arteriole and improving microcirculation is composed of storage layer, adhesive layer, release controlling film, substrate and protecting layer. Its advantages are stable concentration of medicine in blood, sure curative effect and low by-effect.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a transdermal patch containing ligustrazine free base and a preparation method thereof. Background technique [0002] Tetramethylpyrazine (TMP) is an alkaloid monomer isolated from the rhizome of Ligusticum umbelliferum in the early 1970s. Tetramethylpyrazine has pharmacological effects such as dilating blood vessels, increasing coronary blood flow, cerebral blood flow, improving circulation, increasing myocardial contractility, and preventing cell damage caused by ischemia, hypoxia, and reperfusion. In addition, it can pass through the blood-brain barrier, inhibit platelet aggregation and reduce platelet activity. Clinical studies have shown that ligustrazine can significantly increase the content of superoxide dismutase in patients with ischemic cerebrovascular disease, enhance the scavenging of active oxygen free radicals; it can inhibit the cerebral cortex and enhance the functions of ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4965A61M37/00A61P9/10
Inventor 沈腾徐惠南翁伟宇张建芳
Owner FUDAN UNIV
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