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Nitrazepam dripping pills and its preparation process

A technology of nitrazepam dropping pills and nitrazepam, which is applied in the fields of pill delivery, nervous system diseases, drug combination, etc. It can solve the problems affecting the therapeutic effect of nitrazepam, the large proportion of excipients used, and the long disintegration time of tablets, etc. , to achieve the effect of convenient carrying and taking, reduced dosage of excipients, and small pill size

Inactive Publication Date: 2004-11-17
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Nitrazepam is odorless, tasteless, and almost insoluble in water. Its tablet disintegrates for a long time, has poor absorption, low bioavailability, and a large proportion of excipients. It is inconvenient to take for children, the elderly, bedridden patients, and patients with dysphagia. Poor resistance, which affects the therapeutic effect of nitrazepam

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] prescription:

[0023] Nitrazepam 5g

[0024] Macrogol 6000 15g

[0025] Makes 1000 capsules

[0026] Preparation method: Take nitrazepam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by dropping, dry, and obtain .

example 2

[0028] prescription:

[0029] Nitrazepam 5g

[0030] Macrogol 4000 15g

[0031] Makes 1000 capsules

[0032] Preparation method: Take the fine powder of nitrazepam that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by dropping, dry, and obtain .

example 3

[0034] prescription:

[0035] Nitrazepam 5g

[0036] Macrogol 6000 5g

[0037] Macrogol 4000 10g

[0038] Makes 1000 capsules

[0039] Preparation method: Take nitrazepam fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone oil as a coolant, and drip The legal pills are dried and obtained immediately.

[0040] 4. Example 4

[0041] prescription:

[0042] Nitrazepam 5g

[0043] Glyceryl monostearate 15g

[0044] Makes 1000 capsules

[0045] Preparation method: Take the fine powder of nitrazepam that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as the cooling agent, make pellets by drop method, and dry to obtain.

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PUM

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Abstract

The invention relates to a Nitrazepam drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to nitrazepam dropping pills and a preparation method thereof. Background technique [0002] Nitrazepam is a benzodiazepine drug with hypnotic, anxiolytic and strong anticonvulsant effects. The hypnotic effect is similar to short-acting or intermediate-acting barbiturates. It is characterized by causing approximate physiological hypnosis, no obvious sequelae, and strong antiepileptic effect. [0003] The oral absorption of nitrazepam is about 78%, reaching the peak concentration in 2 hours, t 1 / 2 8 to 36 hours. At present, there are only tablets on the market, which are clinically used for various insomnia, and can also treat epilepsy, especially for clononic seizures. [0004] Nitrazepam is odorless, tasteless, and almost insoluble in water. Its tablet disintegrates for a long time, has poor absorption, low bioavailability, and a large proportion o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5513A61P25/08A61P25/20A61P25/22
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG