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Freeze-dried 'Shenqifuzheng' powder for injection and its preparing process

A technology of freeze-dried powder injection and Shenqi Fuzheng, which is applied in the field of preparation technology of Shenqi Fuzheng freeze-dried powder preparation for injection, which can solve the problems of high cost, cumbersome work of recovering ethanol, and inconvenient transportation of injection water

Active Publication Date: 2004-11-17
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Journal of Shanghai University of Traditional Chinese Medicine 2000, 14(3): 61-65); the alcohol precipitation process uses a large amount of ethanol, the cost is high, and the follow-up recovery of ethanol is also cumbersome, and the injection solution has inconvenience in transportation and poor quality stability, etc. problems, which need to be improved to provide better medicines for clinical

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 40g of Codonopsis pilosula and 40g of Astragalus membranaceus, add 10 times the amount of water to decoct 3 times, combine the water extracts, filter, concentrate the filtrate into a medicinal solution equivalent to 1.5g of crude drug per 1ml, centrifuge at high speed, and the supernatant has been pre-treated AB-8 macroporous adsorption resin column, first eluted with 30 times the amount of distilled water, and then eluted with 40% ethanol, and collected the water eluate and alcohol eluate respectively. Concentrate the water eluate to a drug solution with a relative density of 1.15-1.18 (50°C), slowly add ethanol to make the alcohol content reach 70%, let stand overnight, and filter. Add distilled water to dissolve the precipitate, add ethanol and stir to make the alcohol content reach 80%, let it stand, filter, and dissolve the precipitate with distilled water to become a 1% solution, pass through a hollow fiber column ultrafiltration (molecular weight cut-off is g...

Embodiment 2

[0049] Take 40g of Codonopsis pilosula and 40g of Astragalus membranaceus, add 10 times the amount of water to decoct 3 times, combine the water extracts, filter, concentrate the filtrate into a medicinal solution equivalent to 1.5g of crude drug per 1ml, centrifuge at high speed, and the supernatant has been pre-treated AB-8 macroporous adsorption resin column, first eluted with 30 times the amount of distilled water, and then eluted with 95% ethanol, and collected the water eluate and alcohol eluate respectively. Concentrate the water eluate to a drug solution with a relative density of 1.15-1.18 (50°C), slowly add ethanol to make the alcohol content reach 70%, let stand overnight, and filter. Add distilled water to dissolve the precipitate, add ethanol and stir to make the alcohol content reach 80%, let it stand, filter, and dissolve the precipitate with distilled water to become a 1% solution, pass through a hollow fiber column ultrafiltration (molecular weight cut-off is g...

Embodiment 3

[0051] Take 40g of Codonopsis pilosula and 40g of Astragalus membranaceus, add 10 times the amount of water to decoct 3 times, combine the water extracts, filter, concentrate the filtrate into a medicinal solution equivalent to 1.5g of crude drug per 1ml, centrifuge at high speed, and the supernatant has been pre-treated AB-8 macroporous adsorption resin column, first eluted with 30 times the amount of distilled water, and then eluted with 70% ethanol, and the water eluate and alcohol eluate were collected respectively. Concentrate the water eluate to a drug solution with a relative density of 1.15-1.18 (50°C), slowly add ethanol to make the alcohol content reach 70%, let stand overnight, and filter. Add distilled water to dissolve the precipitate, add ethanol and stir to make the alcohol content reach 80%, let it stand, filter, and dissolve the precipitate with distilled water to become a 1% solution, pass through a hollow fiber column ultrafiltration (molecular weight cut-off...

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PUM

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Abstract

The invention relates to a process for preparing Shenqi Fuzheng freeze dried powered injection, which comprises, extracting the effective components in codonopsis pilosula and astragalus root, purifying through macroscopic adsorption resin column, obtaining the polysaccharides effective portion and total saponins effective portion, preparing solution with the two effective portions, charging right amount of excipient, filtering, split charging, sterilizing, and low-temperature freeze drying. íí

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and more specifically relates to a preparation process of a ginseng fuzheng freeze-dried powder preparation for injection. Background technique [0002] Shenqi Fuzheng Injection is a traditional Chinese medicine preparation widely used in clinical practice at present. It is composed of the same amount of Codonopsis pilosula and Astragalus membranaceus. The righting effect of nourishing qi and blood can significantly improve the clinical symptoms of patients with diseases and improve the quality of life. Used in conjunction with chemotherapeutic drugs, it has the effects of synergizing and reducing toxicity, and improving self-immunity. Existing Shenqi Fuzheng Injection is prepared by water extraction and alcohol precipitation (Chinese patent medicine ministerial standard WS-459(Z-065)-95 and WS-387(Z-50)-99), after heating with water, alcohol precipitation , the process uses...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P1/14A61P35/00
Inventor 张正生
Owner TIANJIN TASLY PHARMA CO LTD