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Red sage dripping pill and its prepn

A technology of Danshen and dripping pills, applied in the directions of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of reduction of active ingredients, low release rate of ingredients, first-pass effect, etc.

Inactive Publication Date: 2004-11-24
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] ①Slow disintegration rate of solid oral preparations (such as tablets, capsules, etc.) and low release rate of active ingredients
Such a long time is undoubtedly not helpful for the rapid release of the active ingredients of the drug
[0005] ②First-pass effect problem
Due to its own reasons, oral preparations are mostly absorbed in the gastrointestinal tract, which is prone to first-pass effect, which reduces the active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Preparation of Salvia miltiorrhiza extract: Take 100g of Salvia miltiorrhiza, cut it into pieces, add 6 times the amount of water, heat and extract twice, each time is 1 hour, combine the extracts, filter, and concentrate the filtrate to the volume of the filtrate and the amount of crude drug The ratio is 1:1.5;

[0057] (2) Adsorbed by macroporous adsorption resin (AB-8 type) and washed with water to remove impurities;

[0058] (3) eluting with 90% methanol, collecting the eluent, concentrating and recovering the methanol to a relative density of 1.33 (50-60° C.), and obtaining the extract of Danshen;

[0059] (4) Take the above-mentioned Danshen extract and mix it with polyethylene glycol 4000 in a ratio of 1:2;

[0060] (5) Preparation of the product: take the above-mentioned Danshen extract and polyethylene glycol 4000 and heat it to 85°C, and after 20 minutes of compounding, move it into the drip irrigation of the dripping pill machine and keep it at 75°C. T...

Embodiment 2

[0062] (1) Preparation of Salvia miltiorrhiza extract: Take 100g of Salvia miltiorrhiza, cut it into pieces, add 7 times the amount of water, heat and extract twice, each time is 2 hours, combine the extracts, filter, and concentrate the filtrate to the volume of the filtrate and the amount of crude drug The ratio is 1:1;

[0063] (2) Adsorbed by macroporous adsorption resin (ZTC-1 type) and washed with water to remove impurities;

[0064] (3) eluting with 95% ethanol, collecting the eluate, concentrating and recovering the ethanol to a relative density of 1.35 (50-60° C.), and obtaining the extract of Danshen;

[0065] (4) Mix the above-mentioned salvia miltiorrhiza extract with polyethylene glycol 6000 in a ratio of 1:3;

[0066] (5) Preparation of the product: take the above-mentioned Danshen extract and polyethylene glycol 6000 and heat it to 90°C, and after 20 minutes of compounding, move it into the drip irrigation of the dripping pill machine and keep it at 80°C. The ...

Embodiment 3

[0068] (1) Preparation of Salvia miltiorrhiza extract: Take 100g of Salvia miltiorrhiza, cut it into pieces, add 7 times the amount of water, heat and extract twice, each time is 2 hours, combine the extracts, filter, and concentrate the filtrate to the volume of the filtrate and the amount of crude drug The ratio is 1:1;

[0069] (2) Adsorbed by macroporous adsorption resin (D101 type) and washed with water to remove impurities;

[0070] (3) eluting with 95% propanol, collecting the eluate, concentrating and recovering propanol to a relative density of 1.34 (50-60° C.), and obtaining the extract of Danshen;

[0071] (4) Take the above-mentioned Danshen extract and mix it with polyethylene glycol 6000 in a ratio of 1:2.5;

[0072] (5) Preparation of the product: take the above-mentioned Danshen extract and polyethylene glycol 6000 and heat it to 90°C, and after 20 minutes of compounding, move it into the drip irrigation of the dripping pill machine and keep it at 80°C. The l...

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Abstract

The present invention discloses one kind o red sage dripping pill and its preparation process. Red sage extract is first obtained with red sage and through water extraction, concentration, adsorption in macroporous resin, alcohol elution and concentration, and then mixed with proper amount of supplementary material before prepared into dripping pill. The pharmacological effect of the Chinese medicine is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof. Specifically, the invention relates to a salvia miltiorrhiza dripping pill preparation. The invention also discloses its pharmacological action and preparation method. Background technique [0002] Salvia miltiorrhiza Beg. is the dried root of Salvia miltiorrhiza Beg. In the treatment of coronary heart disease and angina pectoris in my country, it has been used for nearly a thousand years. It was first recorded in the "Shen Nong's Herbal Classic" in the Eastern Han Dynasty and listed as a top grade. [0003] In recent years, along with the in-depth study of Danshen, the oral preparations of Danshen have been developed: Danshen tablets, oral liquids, capsules and granules, etc., but due to the dosage form itself, they all have the following problems: [0004] ①The disintegration speed of solid oral preparations (such as t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/343A61P9/10
Inventor 张文生岳洪水黄芝娟叶正良
Owner TIANJIN TASLY PHARMA CO LTD
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