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Preparation of medicinal film coated rubber plug

A technology of laminating glue and rubber stopper, which is applied in the directions of using stopper to seal, apply, and seal the stopper, can solve the problems of high price and complicated production process, and achieve the effect of low cost, simple and convenient production process, and low consumption of rubber.

Inactive Publication Date: 2004-12-08
上海天汇化学制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to disclose a preparation method of a medicinal compound membrane rubber stopper, so as to overcome the defects of complicated manufacturing process and high price in the prior art

Method used

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  • Preparation of medicinal film coated rubber plug
  • Preparation of medicinal film coated rubber plug
  • Preparation of medicinal film coated rubber plug

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] see figure 2 , the preparation method of medicinal compound film rubber stopper of the present invention, comprises the steps:

[0023] First, the formed rubber plug is cleaned in step 3;

[0024] Apply adhesive to the part of the formed rubber stopper that needs to be laminated. Step 4;

[0025] Step 5 of heating and drying the rubber stopper coated with adhesive;

[0026] Heat the film made of polymer material until it becomes plastic, place it on the above-mentioned glued rubber stopper, and press the film compound on the rubber stopper with a shaping die under vacuum condition Step 6;

[0027] Step 7 of cutting off the excess film is to obtain the laminated rubber stopper of the present invention.

Embodiment 1

[0029] Wash the prepared antibiotic bottle with a concave-shaped natural rubber stopper by ultrasonic water, and after drying, apply polyurethane adhesive (A505) diluted to a certain viscosity with ethyl acetate to the inner cavity and outer surface of the rubber stopper neck. And the top surface of the plug cover, dry in the air at 60°C for 30 minutes, heat a 0.17mm polypropylene film at 120°C until it becomes plastic, put it on the above rubber plug, and press it on the rubber plug with a mold in vacuum , complete the laminating step, and then cut off the excess film at the edge to obtain the laminating rubber plug of the present invention.

Embodiment 2

[0031] After washing and drying the prepared butyl rubber stopper for infusion, the 0.14mm polypropylene film was used as the material for lamination in the same manner as in Example 1.

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Abstract

A filmed rubber plug for medicine is prepared from the shaped rubber plug through coating adhesive onto relative position, heating to remove the solvent from adhesive, heating the high-molecular film until it become plasticized, attaching it on said rubber plug, die pressing in vacuum condition, and removing excessive film. Its advantages are high sealing performance and high-temp resistance, and effective isolation to the soluble components in rubber.

Description

technical field [0001] The invention relates to a preparation method of a medicinal rubber stopper, in particular to a preparation method of a medicinal rubber stopper with a compound film. Background technique [0002] As we all know, rubber stoppers made of natural rubber are widely used in powder injection bottles and large infusion bottles, and recently synthetic butyl rubber stoppers are gradually used. The components of the rubber plug include rubber (natural, synthetic), vulcanizing agent, vulcanization accelerator, filler, plasticizer, etc., and natural rubber also contains many other components, such as macromolecules such as protein. When the rubber stopper is in contact with the medicine or liquid medicine, it will release these impurities and particles, which will affect the quality of the medicine and human health. [0003] In order to overcome these shortcomings of rubber stoppers, a lot of work has been done at home and abroad, such as filling a layer of poly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/14B65D39/00
Inventor 侯炯
Owner 上海天汇化学制药有限公司