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Rapid disintegration and rapid dissolution tablet containing kakonein

A technology of puerarin and disintegrant, applied in the field of pharmaceutical preparations, can solve problems such as slow absorption, incomplete absorption, and slow drug dissolution

Inactive Publication Date: 2005-02-09
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug dissolves slowly and absorbs slowly, so the onset of action is slow, and it is difficult to guarantee the curative effect due to incomplete absorption

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Rapid Disintegration and Rapid Dissolution Tablets Containing Puerarin Using Microcrystalline Cellulose as Filler

[0023] Raw materials and accessories

[0024] Prepare as follows.

[0025] Pass the active ingredient puerarin in the formula and the listed excipients through 80-mesh sieve respectively.

[0026] Mix puerarin, microcrystalline cellulose, lactose, crospovidone, aspartame, poloxamer, citric acid, and sodium bicarbonate evenly.

[0027] Add 5% starch slurry to make soft material, extrude and sieve through a 20-mesh sieve to granulate.

[0028] The wet granules were dried at a constant temperature of 60°C for 2 hours.

[0029] The dry granules are sieved with a 20-mesh sieve.

[0030] Add magnesium stearate and mix well.

[0031] It is compressed on a tablet machine, with an average tablet weight of 300mg~350mg, and a tensile strength of 20~50 Newtons.

[0032]The disintegration time limit of the orally disintegrating tablet was che...

Embodiment 2

[0036] Embodiment 2: Puerarin orally rapidly disintegrating tablet containing mannitol as a filler

[0037] Raw materials and accessories

Recipe.4

Recipe 5

Recipe 6

Puerarin

25.00mg

50.00mg

75.00mg

Mannitol

110.00 mg

170.00mg

200.00mg

Crospovidone

25.00mg

40.00mg

60.00mg

aspartame

ester

8.00mg

8.00mg

8.00mg

citric acid

5.00mg

5.00mg

5.00mg

sodium bicarbonate

6.00mg

6.00mg

6.00mg

Poloxamer

2.00mg

2.00 mg

2.00 mg

Iron oxide (red)

0.001％

0.001％

0.001％

5% starch slurry

Conventional amount

Conventional amount

Conventional amount

Magnesium stearate

1％

1％

1％

[0038] The preparation steps are the same as in Example 1.

[0039] Compressed on a tablet machine, the average tablet weight is between .190mg and 370mg, and the tensile strength is between 20 and...

Embodiment 3

[0043] Embodiment 3: Puerarin orally disintegrating tablet containing carbohydrates and starches.

[0044] Raw materials and accessories

Recipe.7

Recipe 8

Recipe 9

Puerarin

50.00mg

50.00mg

50.00mg

glucose

50.00mg

25.00mg

75.00mg

pregelatinized starch

50.00mg

75.00mg

25.00mg

Sodium carboxymethyl starch

40.00mg

40mg

40mg

aspartame

ester

8.00mg

8.00mg

8.00mg

citric acid

5.00mg

5.00mg

5.00mg

sodium bicarbonate

6.00mg

6.00mg

6.00mg

Poloxamer

2.00mg

2.00 mg

2.00 mg

Iron oxide (red)

0.001％

0.001％

0.001％

5% starch slurry

Conventional amount

Conventional amount

Conventional amount

Magnesium stearate

1％

1％

1％

[0045] The preparation steps are the same as in Example 1. Sugar and starch are used as fillers and disintegrants, which are low ...

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PUM

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Abstract

The present invention belongs to the field of medicine preparation, and relates to one kind of quick disintegrating and leaching tablet containing puerarin as active component. Puerarin as active component is mixed with disintegrating agent, stuffing, corrective, lubricant, effervescent agent, adhesive and coloring agent, and the mixture is pressed into the quick disintegrating and leaching tablet. Each tablet contains puerarin in 10-100 mg, disintegrating agent in 2-20 wt% and co-solvent 1-10 wt%. The tablet of the present invention can disintegrate in 1 min after contacting with saliva in oral cavity and leach out 80 % over in 3 min.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a rapidly disintegrating and rapidly dissolving tablet, in particular to a rapidly disintegrating and rapidly dissolving tablet containing puerarin as an active ingredient. Background technique [0002] Orally fast-disintegrating tablet (orally rapidly-disintegrating tablet, ororally rapidly-disintegrating tablet) is a new pharmaceutical preparation that has emerged at home and abroad in the past ten years. features. Orally rapidly disintegrating tablets can be administered without water and with only a small amount of saliva. Generally speaking, orally rapidly disintegrating tablets should disintegrate within 1 minute after contacting saliva in the oral cavity. After disintegration, the drug is rapidly dissolved or dispersed into small particles, which speeds up the absorption and makes the onset of effect rapid. This dosage form is suitable for: (1) patients with swall...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7048A61P9/10
Inventor 吴伟阙俐姚帮新胡弢
Owner FUDAN UNIV
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