Unlock instant, AI-driven research and patent intelligence for your innovation.

Chinese medicine for tumour and depression and its preparation

A technology for depression and traditional Chinese medicine, which is used in anti-tumor drugs, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve problems such as insufficient use of drugs, no novelty, and inability to achieve industrial transformation.

Inactive Publication Date: 2005-02-23
张正生
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The patent application No. 02111386 uses madecassoside in total asiaticosides for the treatment of depression, but this patent uses conventional extraction methods without patent novelty, and at the same time uses silica gel column chromatography to purify hydroxyasiatica Grass glucoside, this method can't realize industrial transformation in the actual production process, so lacks the practicability of the patent; Patent CN1194154A describes the preparation method of Asiaticoside, but the method is complicated, the process is cumbersome, and more organic compounds are used. Solvent, serious environmental pollution, is harmful to the health of actual operators; the patent of patent application No. 01113014 has set forth the antidepressant effect of the effective part of Centella asiatica - total glycosides of Centella asiatica, but the antidepressant effect of Centella asiatica Another anti-depressant effective part-Centella asiatica volatile oil has not been extracted and purified, which wastes resources and does not fully exert the effect of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Comparison of Inhibition of Liver Tumors in Rats

[0020] Experimental animals: 50 rats, 150g-180g, male or female, were divided into 5 groups, 10 rats in each group, used for the blank group and the experimental groups of the two preparations respectively.

[0021] Experimental drug: normal saline (provided by the laboratory of Beijing Qianluchun Technology Co., Ltd.)

[0022] Commercially available Aidi injection (purchased by Beijing Baitasi Pharmaceutical Wholesale Company, produced by Guizhou Yi Pharmaceutical Co., Ltd.)

[0023] Each group of preparations of the present invention is provided by the laboratory of Beijing Ganluchun Science and Technology Co., Ltd.)

[0024] Experimental method: Take rats for intrahepatic inoculation of W256. Seven days after the inoculation, they were anesthetized by intraperitoneal injection of pentobarbital sodium at a dose of 35 mg / kg, fixed, exposed the liver by laparotomy, and measured the maximum diameter of the tumor surface...

Embodiment 2

[0032] Physical, chemical and biological factors can all induce cancer, but 80%-90% of the causes of human cancer are believed to be caused by environmental chemicals.

[0033] Inhibitory effects of two preparations on diethylnitrosamine (DENA)-induced liver cancer in rats

[0034] Experimental animals: 50 rats, about 120 g, male or female, were divided into 5 groups, 10 rats in each group, used for the blank group and the experimental groups of the two preparations respectively.

[0035] Experimental drug: normal saline (provided by the laboratory of Beijing Qianluchun Technology Co., Ltd.)

[0036] Commercially available Aidi injection (purchased by Beijing Baitasi Pharmaceutical Wholesale Company, produced by Guizhou Yibai Pharmaceutical Co., Ltd.)

[0037] Each group of preparations of the present invention (Beijing Ganluchun Science and Technology Co., Ltd. laboratory provides)

[0038] Experimental method: Rats were fed with drinking water containing diethylnitrosamine...

Embodiment 3

[0045] Influence of Neuroendocrine Function in Depressed Rats

[0046] Experimental animals: 60 male SD rats, weighing 160-180g, provided by the Animal Laboratory of Peking University, and the rats were randomly divided into negative control group (normal saline group), positive control group (hypericin tablets), and experimental group ( Each group of preparations of the present invention)

[0047] Experimental method: The animal depression model induced by long-term unpredictable stress stimuli was used. The depressive animals in each group were intragastrically administered twice a day, and after 14 days of administration, the serum TSH and T levels of the animals in each group were determined. 3 , T 4 and rT 3 concentration.

[0048] The results are shown in Table 5:

[0049] Table 5 Effects of each group of preparations on neuroendocrine in rats

[0050] group

TSH

(z / mU*l -1 )

T 3

(cB / mmol*l -1 )

T 4

(cB / mmol*l ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A Chinese medicine in the form of injection, powder injection, or perfusion for treating depression and tumor is prepared from asiatic pennywort herb and auxiliary.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a traditional Chinese medicine preparation for treating depression and tumors and a preparation method thereof. Background technique [0002] Centella asiatica (L.) Urban. (Hydrocotyle asiatica L.) is the dried whole herb of Centella asiatica of Umbelliferae, distributed in Jiangsu, Anhui, Zhejiang, Jiangxi, Hunan, Hubei, Fujian, Taiwan, Guangdong, Guangxi, Shaanxi, Sichuan, Yunnan and other provinces are very rich in resources. Centella asiatica is a commonly used traditional Chinese medicine. It is slightly cold in nature and bitter in taste. It was first recorded in "Shen Nong's Materia Medica". It has the effects of clearing away heat and dampness, detoxifying and reducing swelling. . Recent research continues to show that Centella asiatica has many new uses. [0003] The literature "Chinese Herbal Medicine" (1996, 09) "The Antican...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K9/19A61P25/24A61P35/00
Inventor 张正生
Owner 张正生