Method for separation purification of polyhydroxy-alkyl-pyrazine from suger amine reaction liquid

Abstract

This invention discloses a method of separately purifying caoboxyl alkyl pyrazine from sugar ammonium reaction liquor. Compound got by reaction of sugar and ammonia is pressed let in acceptable filtration membrane (retention molecular weight is more than 200) or exceed filtration membrane (retention molecular weight is more than 1000) from material storage tank. Macromolecule matter is entrapped by membrane module, parts feed liquids penetrate the two membranes (there is multi-caoboxyl alkyl pyrazine, and macromolecule matter content is low or absence because of entrapped by membrane module), the material liquid that don't penetrate the membrane module is sent back to material storage tank through tubes and then sent to membrane modules to be separated. Pure water can be added to material storage tank for dilution at the later stage of separation, then acceptable filtration or exceed filtration is kept on to make the multi-caoboxyl alkyl pyrazine penetrate the module along with the penetration liquid at the best. All penetration liquids are collected and pure multi-caoboxyl alkyl pyrazine category matter can be got after concentration, extraction, decoloration, crystallization or using chromatogram etc. technologies. It can be used as spice or medicine materials. The material liquid can be directly used to perfuming and charging of cigarette to improve taste of cigarette and other aspects.

Description

technical field

[0001] The invention relates to a method for separating and purifying polyhydroxyalkylpyrazines from sugar ammonium reaction liquid. Background technique

[0002] Polyhydroxyalkylpyrazines exist in plants such as Panax notoginseng and tobacco. The polyalkylpyrazines in plants are obtained from reducing sugars in plants such as glucose and amino compounds through Amadori rearrangement and a series of complex reactions, and these substances can be used as cigarette additives to enhance flavor. Li Qi et al reported the isolation of 2-(1′,2′,3′,4′-tetrahydroxybutyl)-6-(2″,3″ from Panax notoginseng in the 2001 Vol. , 4 "-trihydroxybutyl)-pyrazine and confirm its structure with synthetic method, and find that it has better anticancer activity. U.S. Patent No. 6,392,042 discloses a class of polyalkylpyrazines for the treatment of diabetes Previous studies have shown that the reaction of sugar and amino compounds often produces more macromolecular substances, calle...

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