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Special equipment for fabricating frozen tissue micro array carrier

A tissue microarray and special equipment technology, which is applied in the preparation of test samples and other directions, can solve the problems of high efficiency and high accuracy of medical research, difficulty in making high-density array carriers, and easy detachment of sample tissue points. To avoid the loss of sample tissue points, the production process is simple, and the production cost is low

Inactive Publication Date: 2005-04-13
大连高新园区全国高技术产业化微生态中试基地
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  • Abstract
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AI Technical Summary

Problems solved by technology

The OCT material carrier method does overcome the shortcomings of the paraffin-embedded sample tissue array method, but because the OCT material is brittle when it is lower than -20 ° C, and the matrix becomes soft when it is higher than -10 ° C, it is difficult to make a high-density array. Carrier, the highest density can only reach 30 holes / cm
In addition, OCT materials still have problems such as uneven arrays after slicing, and sample tissue points are easy to fall off, deform, and overlap during the experiment, which cannot meet the high efficiency and high accuracy requirements of medical research.

Method used

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  • Special equipment for fabricating frozen tissue micro array carrier
  • Special equipment for fabricating frozen tissue micro array carrier

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Embodiment Construction

[0018] The specific embodiment of the present invention will be illustrated below in conjunction with the accompanying drawings: get fresh chicken gizzards, preferably chicken gizzards about 1 hour after slaughter, place them in liquid nitrogen for ultra-low temperature quick freezing, and then freeze the chicken gizzards after quick freezing at -20 Shaping is carried out in a frozen state at ~-35°C, that is, quick-frozen chicken gizzards are cut into small pieces with a size of 0.8cm×0.8cm×0.5cm or 0.6cm×0.6cm×0.5cm to form the matrix 1 . Then, in the frozen state of -75~-80℃, an array of small holes 2 with a diameter of 0.6 mm and a depth of 3 to 5 mm are drilled on the substrate 1, and the distance between the small holes 2 is 0.7 mm, thus forming a figure 2 Frozen tissue microarray vectors are indicated. Special equipment is required for drilling, and the structure of the special equipment is as follows: figure 2 As shown: a stage 3 is provided, and a lifting rod 4 is f...

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Abstract

The present invention is apparatus specially for making frozen tissue micro array carrier, which has base body of freeze treated chicken gizzard with holes. The making process includes ultra-low temperature fast freezing fresh chicken gizzard in liquid nitrogen; shaping the fast frozen chicken gizzard in -35~-20 deg.c to form the base body; and drilling holes in the base body at -85~-75 deg.c. The special drilling apparatus may be a reformed drilling machine with base body fixture with coordinates and capable of moving horizontally. The present invention has frozen tissue micro array carrier with low cost, high density of holes and other advantages, and can produce great amount of detected specimens.

Description

[0001] This application is a divisional application with the patent application number 02109826.3, the filing date being May 24, 2002, and the invention title being "Frozen Tissue Microarray Carrier, Manufacturing Method and Special Equipment for Manufacturing". Technical field: [0002] The invention relates to a product applied in biomedical research, teaching and clinical analysis, a production method of the product and special production equipment. In particular, a frozen tissue microarray carrier applied in cancer genomics, a manufacturing method of the frozen tissue microarray carrier, and special manufacturing equipment. Background technique: [0003] At present, cancer has become one of the major killers threatening human life, and people are actively seeking ways to conquer cancer. Cancer genomics research is to compare the similarities and differences of the gene structure and function of human normal cells, precancerous lesions and malignant tumor cells, and scree...

Claims

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Application Information

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IPC IPC(8): G01N1/28G01N1/44
Inventor 李宏孔庆友孙媛刘佳陈晓燕王晓炜赵杰王茜张开立
Owner 大连高新园区全国高技术产业化微生态中试基地
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