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Fleabane extraction method and preparation of its extract dispersion tablet and drop pills

A technology of Asarum radix and extract is applied in the field of preparation of dispersible tablets and drop pills, and can solve problems such as inconvenience in use, complex components, aging capsule shells, etc.

Inactive Publication Date: 2005-04-20
BEIJING BOERDA BIO TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For these kinds of breviscapine preparations, the injections undoubtedly have the disadvantage of being inconvenient to use, and because of the complex composition of traditional Chinese medicine injections, a little carelessness in the process of production and storage will cause great safety problems; ordinary tablets and granules are both There are disadvantages such as slow absorption and low bioavailability, and granules also have disadvantages such as moisture absorption and caking; soft capsules have serious capsule shell aging problems, and they usually disintegrate for more than 40 minutes or even do not disintegrate after 1.5 years of storage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Extraction method of Erigeron breviscapus

[0013] Take scutellaria lanceolata, crush it into a coarse powder, add 6 times and 4 times the amount of 80% ethanol to reflux extract twice, each time for 2 hours, filter, recover the ethanol from the filtrate to a thick paste, add 0.1% sodium hydroxide to dissolve, After filtration, the filtrate was extracted three times with 1.5 times the amount of water-saturated n-butanol, and the n-butanol liquid was separated. The aqueous layer was adjusted to pH 2-3 with 10% sulfuric acid, and then extracted three times with 1.5 times the amount of water-saturated n-butanol, and the n-butanol liquid was separated. Combine the n-butanol liquid, recover n-butanol to a thick paste. The precipitate was collected by filtration from the water layer, combined with the above-mentioned thick paste, dissolved in 1% sodium hydroxide (relative density 1.10±0.1), and dried to obtain dry powder of the extract. The content of scutellarin ...

Embodiment 2

[0014] Example 2 Preparation of breviscapine extract dispersible tablets

[0015] Erigeron extract 40g

[0016] 130g microcrystalline cellulose

[0017] Carboxymethyl starch sodium 20g

[0018] Magnesium Stearate 1.0g

[0019] 60% ethanol appropriate amount

[0020] Preparation Process:

[0021] Take the dry powder of the extract, add 10 grams of carboxymethyl starch sodium, 130 grams of microcrystalline cellulose, add 60% ethanol in an appropriate amount to make a soft material, pass through a 18-mesh sieve to granulate, dry at 50 ° C, granulate with a 20-mesh sieve, and then add carboxymethyl 10 grams of sodium starch glycolate and 1.0 grams of magnesium stearate, fully mix, measure the content of scutellarin in the whole granules, calculate the tablet weight according to this content, adjust the appropriate pressure for tableting, and make 1000 scutellarin dispersible tablets Slices, ready to serve.

[0022] According to Chinese Pharmacopoeia 2000 edition, the paramet...

Embodiment 3

[0026] Example 3 Preparation of breviscapine extract dispersible tablets

[0027] Erigeron extract 40g

[0028] 130g microcrystalline cellulose

[0029] crospovidone 20g

[0030] Magnesium Stearate 1.0g

[0031] 60% ethanol appropriate amount

[0032] Preparation Process:

[0033] Take the dry powder of the extract, add 10 grams of crospovidone, 130 grams of microcrystalline cellulose, add 60% ethanol in an appropriate amount to make a soft material, pass through a 18 mesh sieve to granulate, dry at 50 ° C, granulate with a 20 mesh sieve, and then add cross-linked Combine 10 grams of polyvidone and 1.0 grams of magnesium stearate, mix well, measure the content of scutellarin in the finished granules, calculate the tablet weight according to this content, adjust the appropriate pressure to press the tablet, and make the scutellarin dispersible tablet 1000 tablets, that is.

[0034] The resulting dispersible tablets have the following properties:

[0035] In water at 20°C...

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PUM

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Abstract

A extracting method for fleabane and method for preparing dispersion flake and drop bill of extract. The process is that fleabane is pulverized, added with 80 % alcohol extracted two times, filtered until alcohol become thick paste, added with 0.1 % sodium hydroxide, filtered, filtered solution is extracted by water saturated normal butyl alcohol, recovering normal butyl alcohol until it becomes thick paste. The drop bill disintegrating agent is made from low substituted hydroxypropyl cellulose, sodium carboxymethyl starch, crosslinked sodium cellulose glycolate, crosslinked polyvinyl pyrolidon. The weight of disintegrating agent is 5-25 % of total weight. The water soluble base of drop bill is made from carbowax 4000, carbowax 6000, carbowax 1500, carbowax 400, carbowax 600, carbowax 1000, sodium stearate, glycerogelatin, one or several kinds of poloxamer. The proportion of extract dry powder and water soluble base is 1 : 2-10.

Description

technical field [0001] The invention relates to an extraction method of traditional Chinese medicine and two pharmaceutical preparations of the obtained extract, in particular to an extraction method of Erigeron breviscapus and a preparation method of dispersible tablets and dripping pills of the obtained extract. Background technique [0002] Erigeron breviscapus has obvious curative effect in the treatment of cardiovascular diseases, and its market prospect is very broad. Erigeron breviscapus has fibrinolytic activity, which can inhibit and reduce the blood coagulation function in the body, thereby effectively inhibiting the formation of thrombus. In addition, this product also has the ability to reduce cerebrovascular resistance. Increase blood flow, improve cerebral blood circulation, increase nutritional myocardial blood flow and improve blood-brain barrier permeability and other pharmacological effects. [0003] Breviscapus preparations are mainly used for the treatm...

Claims

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Application Information

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IPC IPC(8): A61J3/00A61J3/06A61J3/10
Inventor 孟旻肖云彩张成飞李燕芬程涛
Owner BEIJING BOERDA BIO TECH DEV
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