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Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity

An antifungal and antiviral technology, which is used in antifungal, ointment delivery, medical raw materials derived from bacteria, etc.

Inactive Publication Date: 2005-06-22
MCNEIL PPC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many treatments require multiple days of treatment and multiple daily applications

Method used

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  • Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity
  • Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity
  • Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Miconazole nitrate 16.00%

[0062] White Vaseline 25.00%

[0063] Wecobee M (Wecobee is a vegetable oil base) 16.00%

[0064] Polyethylene glycol 400 20.00%

[0065] Polyethylene glycol 3350 8.00%

[0066] Stearyl alcohol 3.50%

[0067] Colloidal silica 1.50%

[0068] Sodium carboxymethyl cellulose 7.00%

[0069] Xanthan gum 3.00%

Embodiment 2

[0071] Miconazole nitrate 24.00%

[0072] White Vaseline 20.00%

[0073] Wecobee M 13.00%

[0074] Polyethylene glycol 400 20.00%

[0075] Polyethylene glycol 3350 8.00%

[0076] Stearyl alcohol 3.50%

[0077] Colloidal silica 1.50%

[0078] Sodium carboxymethyl cellulose 7.00%

[0079] Xanthan gum 3.00%

Embodiment 3

[0081] Miconazole nitrate 16.00%

[0082] White Vaseline 31.00%

[0083] Wecobee FS (The melting point of Wecobee FS is 10.00%

[0084] Wecobee M high)

[0085] Polyethylene glycol 400 20.00%

[0086] Polyethylene glycol 3350 8.00%

[0087] Stearyl alcohol 3.50%

[0088] Colloidal silica 1.50%

[0089] Sodium carboxymethyl cellulose 7.00%

[0090] Xanthan gum 3.00%

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PUM

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Abstract

The ointments and methods described herein are useful for treating fungal and yeast infections of the oral cavity and vagina. Ointments containing antifungal and / or antibacterial agents, and a mixture of water-soluble and water-insoluble components, which are effective in single or multiple doses for the treatment of oral and / or vaginal Fungal and / or antibacterial agents are kept above a minimum concentration. The method of treating infection with a single dose includes a method of determining at set intervals whether the ointment is effective in a single dose blood concentration test of antifungal and antibacterial agents.

Description

Invention field [0001] The present invention relates to a special oral and vaginal antifungal ointment and antibacterial ointment for single-dose or multi-dose application, and for delivering antifungal ointment and antibacterial ointment to the oral cavity or vaginal cavity, and determining these ointments The residence time of the agent in the cavity. [0002] Infections in the vagina are caused by yeast (a type of fungus called Candida) and / or bacteria, the most common being bacterial vaginosis. If these infections are not properly treated, these infections can be very uncomfortable and even painful. Generally, these infections are treated locally with antifungal or antibacterial creams, suppositories, soft gelatin capsules, vaginal tablets, and ointments. The therapeutic effect can last from a few days to 1 day. [0003] There are also fungal and bacterial infections in the mouth. Since the therapeutic composition must remain in the oral cavity for sufficient treatment time, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/00A61K31/4164A61K31/4174A61K31/717A61K31/795A61K35/74A61K45/00A61K47/02A61K47/10A61K47/34A61K47/36A61K47/38A61M37/00A61P31/10G01N33/569
CPCA61K9/0034A61K9/0043A61K9/006G01N33/56961A61P31/10A61K9/06A61K9/00
Inventor A·纳瓦斯S·Y·林K·J·帕特尔M·休西斯
Owner MCNEIL PPC INC
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