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Chimonanthus nitense leaf drop pills for preventing common cold and preparation technique thereof

A technology for the leaves and cold medicine of C. chinensis, which is applied to the field of Prunus chinensis leaf dropping pills and the preparation technology thereof, can solve the problems of unstable quality, volatilization of volatile oil, short shelf life and the like, and achieves good reproducibility, less exposure to air, Ease of use

Active Publication Date: 2005-07-06
江西佑美制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its dosage is large (10 g / time, three times a day), and the volatile oil is easy to volatilize from the granules, resulting in short shelf life and unstable quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: (200 dosage)

[0050] Get 0.3g of 1,8-cineole in the volatile oil of waxberry leaves, 0.7g of flavonoid aglycone extracted from waxberry leaves, 1g of lactose, 3g of polyethyl alcohol 4000, 3g of polyethyl alcohol 6000, and 0.06g of polysorbate-80; Mix the main ingredient and lactose evenly according to the method of equal amount addition to obtain (a), and take another prescription amount of polyethylene glycol 4000 and 6000 and heat and melt in a water bath at 100°C to obtain (b); add (a) to (b), and add polysorbate-80, stir evenly, move into the liquid storage bottle of the dropping pill instrument that is kept warm to 57 ℃, after the temperature is constant, control the temperature of the dripper to 40~45 ℃ and drip at a speed of 60 pills per minute to In the glass column of liquid paraffin, filter to obtain drop pills, absorb and dry with talc powder, and each drop pill weighs about 40.0 mg.

Embodiment 2

[0052] Take 0.5 g of 1,8-cineole and flavonoid aglycone extracted from the leaves of Waxweed, 100 g of sodium stearate, and 25 g of insect wax, mix and heat to 100° C. to melt them all. When dripping, use 1% sulfuric acid aqueous solution as the condensate. Keep the medicine solution at 65°C and drop out from the mouth of the dropper. The molten liquid of the main drug and the matrix is ​​dripped into the condensate from the lower part of the condensate, and about 200 drop pills are dripped out per minute from each dropper. The pills slowly drip out from the drop opening and float up, condense while rising, filter out the dripping pills, immerse in cold water to remove the attached acid, then place them on a tray with absorbent paper and roll them. Absorb the water traces on the surface of the pills to obtain the product (the inner diameter of the dropper is 4.9mm, and the outer diameter is 8.04mm).

Embodiment 3

[0054] Get 1,8-cineole 0.5g, flavonoid aglycone 1g, sodium stearate 150g polyethylene glycol 4000 7g lactose 2g extracted in the waxberry leaf, and the method described in Example 1 is used to obtain the present invention. The anti-cold medicine Shanxueye Dropping Pills.

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PUM

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Abstract

The invention discloses a Chimonanthus nitense leaf drop pills for preventing common cold and preparation process, wherein the drop piils comprises (by weight ratio) 1,8cineole 1-10 parts and flavonoid glycoside 1-10 parts extracted from Chimonanthus intense leaves, water-based or oil-based base material 7-150 parts, excipient 0.01-10 parts.

Description

technical field [0001] The invention relates to an anti-cold medicine, in particular to an anti-cold medicine Shanwameiye dripping pill and a preparation process thereof. Background technique [0002] Chimonanthus nitens oliv leaves are the dried leaves of Chimonanthus nitens oliv, a plant of the genus Chimonanthaceae. It has been used by folks for a long time to prevent and treat colds and influenza. 1977 edition. Many clinical studies have been done on the chemical constituents, medicinal chemistry and pharmacology of waxberry leaves, and experiments on antibacterial and anti-influenza viruses have also been done, but they are all limited to crude extracts, and no single effective antiviral ingredient has been found. [0003] The chemical constituents of waxberry leaves include: [0004] (a) Volatile oil It is light yellow transparent oily liquid with special aroma. Gas chromatography analysis, containing 1,8-cineole (1,8-cinceol), linalool (linalool), α-pinene (α-pinen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P31/00
Inventor 邱俊生
Owner 江西佑美制药有限公司
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