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Maple knotweed mixture for intestine and stomach hualth and its manufacturing method

A technology of health mixture and intestines and stomach, which is applied in the field of traditional Chinese medicine preparations for the treatment of acute gastroenteritis and its preparation, can solve the problems of reducing drug efficacy, slow absorption, long dissolution time, etc., and achieve accurate dosage, guaranteed curative effect, and stable quality Effect

Active Publication Date: 2005-08-10
海南万州绿色制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) Pediatrics are not easy to accept, and it is inconvenient to take the medicine, and the medicine for children should be administered in different doses according to age or weight, while the solid preparation is difficult for children to take, and the dosage is not easy to grasp accurately
[0005] (2) Some patients who have difficulty swallowing solid drugs (such as the elderly and infirm) have difficulty in taking medicine
[0006] (3) The dissolution time of solid drugs is longer after oral administration, the absorption is slower, and the drug effect is not timely
[0007] In view of the above-mentioned problems existing in the solid preparation of Fengliao Changweikang, pharmaceutical workers have always hoped to prepare Fengliao Changweikang into a liquid preparation, that is, in the form of a mixture, but the drug is unstable in solution, prone to precipitation and the active ingredient total flavonoids It is easy to polymerize and reduce the drug effect, so there is no report of Feng Liao Chang Wei Kang liquid preparation (mixture)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Prescription: Niu Erfeng 2000g Spicy Polygonum 1000g

[0031](2) Process: Decoct the above two flavors twice with water, add 6 times the amount of water for the first time, 1.5 hours, add 4 times the amount of water for the second time, 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.05 (heat measurement at 60°C), place at 3-6°C for 48 hours, filter, add 150ml glycerin, 2g sodium bisulfite, 2g sodium benzoate, 150g sucrose to the filtrate, stir to dissolve, add water to 1000ml, stir well, filter, pour Sealed, 60ml per bottle, ready to serve. The obtained medicinal solution was placed for 6 months, no precipitation was found, and the rutin content was determined to be 99.5% of that of 0 month by HPLC.

Embodiment 2

[0033] (1) Prescription: Niu Er Feng 2500g Polygonum Polygonum 1000g

[0034] (2) Process: decoct the above two flavors twice, add 6 times the amount of water for the first time, 2 hours, add 4 times the amount of water for the second time, 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.03 (heat measurement at 60°C), place at 3-6°C for 24 hours, filter, add 100ml glycerin, 2.5g sodium bisulfite, 2g sodium benzoate, 150g sucrose to the filtrate, stir to dissolve, add water to 1000ml, stir well, filter, Potting, 120ml per bottle, ready to serve. Gained medicinal solution was placed for 12 months, and no precipitation was found. The rutin content was determined by HPLC method to be equivalent to 99.1% of that in October.

Embodiment 3

[0036] (1) Prescription: Niu Erfeng 3000g Spicy Polygonum 1000g

[0037] (2) Process: decoct the above two flavors twice, add 8 times the amount of water for the first time, 2.5 hours, add 5 times the amount of water for the second time, 1.5 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.07 (heat measurement at 60°C), place at 3-6°C for 24 hours, filter, add 250ml glycerin and 2.5g sodium bisulfite to the filtrate, stir to dissolve, add water to 1000ml, stir well, filter, potting, 120ml per bottle, Instantly. Gained medicinal solution was placed for 18 months, and no precipitation was found. Determination wherein the rutin content is equivalent to 98.9% of October.

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PUM

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Abstract

A Chinese medicine in the form of mixture for treating acute gastroenteritis is prepared from calyx-shaped daphniphyllum, salicileaf dockleaved knotweed heab, and the medical carrier chosen from glycerine and sodium hydrogen sulfite.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and more specifically relates to a traditional Chinese medicine preparation for treating acute gastroenteritis and a preparation method thereof. Background technique [0002] Acute gastroenteritis is bacterial inflammation. This disease is a common and frequently-occurring disease of human beings, mostly caused by eating unclean food, especially for children in rural areas. Existing Fengliao Changweikang preparations are all solid preparations such as tablets, capsules and granules. For example, CN1080175A discloses a preparation method of Fengliao Changweikang Granules. Finally, powdered sugar and dextrin are added to prepare Fenglian Changweikang Granules, and the finished product of the preparation is solid granules. [0003] However, solid preparations have the following problems: [0004] (1) It is not easy for children to accept the medicine, and it is inconvenien...

Claims

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Application Information

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IPC IPC(8): A61P1/04
Inventor 邝继鲜
Owner 海南万州绿色制药有限公司
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