Method for ectracting general alkaloid of Chinese goldthread and evodia fruit and preparation
A technology of total alkaloids and extraction methods, applied in the direction of alkaloids, alkaloids, chemical instruments and methods, etc., can solve the problem of low alkaloid extraction yield, low transfer rate of fat-soluble alkaloids, inability to fully obtain fat-soluble active ingredients, production Difficult to operate and other problems, to achieve the effects of obvious pharmacological effects, improved transfer rate, and less difficult to operate
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Embodiment 1
[0028] Example 1: Follow the steps below:
[0029] a. Preparation: Take 21kg of Coptis and Evodia 3.5kg as raw materials, pulverize Coptis and Evodia into coarse powder and mix to obtain powder;
[0030] b. Extraction: Add 196kg of 90% ethanol to the powder, extract twice, 1 hour each time, filter and combine the filtrate to obtain the ethanol extract; the medicine residue is decocted twice with 196kg water, 1 hour each time , Filter, combine the decoction liquid and concentrate to a relative density of 1.0~1.2 to obtain a concentrated liquid;
[0031] c. Recover ethanol from the ethanol extract of step b to obtain a thick paste, extract twice with 24500ml ethyl acetate, and recover the ethyl acetate to obtain extract A and aqueous solution; the aqueous solution and the concentrated solution of step b are combined, stand still, and filter The filtrate was adjusted to pH 2.0 with hydrochloric acid, NaCl was added to make the content 6% (weight / volume), stirred to dissolve, filtered...
Embodiment 2
[0034] Example 2: Follow the steps below:
[0035] a. Preparation: Take 21kg of Coptis and Evodia 3.5kg as raw materials, pulverize Coptis and Evodia into coarse powder and mix to obtain powder;
[0036] b. Extraction: Add 147kg of 70% ethanol to the powder, extract 2 times at reflux, 1 hour each time, filter and combine the filtrate to obtain the ethanol extract; the medicine residue is decocted twice with 147kg water, 1 hour each time , Filter, combine the decoction liquid and concentrate to a relative density of 1.0~1.2 to obtain a concentrated liquid;
[0037] c. Recover ethanol from the ethanol extract of step b to obtain a thick paste, extract twice with 49000ml ethyl acetate, and recover the ethyl acetate to obtain extract A and an aqueous solution; the aqueous solution and the concentrated solution of step b are combined, stand still, and filter , The filtrate was adjusted to pH 1.0 with hydrochloric acid, NaCl was added to make the content 5% (weight / volume), stirred to d...
Embodiment 3
[0040] Example 3: Follow the steps below.
[0041] a. Preparation: Take 21kg of Coptis and Evodia 3.5kg as raw materials, pulverize Coptis and Evodia into coarse powder and mix to obtain powder;
[0042] b. Extraction: Add 245kg of 95% ethanol to the powder, extract 2 times at reflux, 1 hour each time, filter, combine the filtrate to obtain the ethanol extract; the medicine residue is decocted twice with 245kg water, 1 hour each time , Filter, combine the decoction liquid and concentrate to a relative density of 1.0~1.2 to obtain a concentrated liquid;
[0043] c. Recover ethanol from the ethanol extract of step b to obtain a thick paste, extract twice with 98000 ml of ethyl acetate, and recover the ethyl acetate to obtain extract A and an aqueous solution; the aqueous solution and the concentrated solution of step b are combined, stand still, and filter The filtrate was adjusted to pH 4.0 with hydrochloric acid, NaCl was added to make the content 10% (weight / volume), stirred to d...
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