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Analyzing tool being reduced in distance of diffusion of reagent and method for manufacture thereof

A technology for analysis tools and manufacturing methods, which is applied in the fields of analyzing materials, analyzing materials by observing the influence on chemical indicators, chemical instruments and methods, etc., and can solve problems such as poor stability, reduced measurement accuracy, and measurement errors

Inactive Publication Date: 2011-04-13
ARKRAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this case, if the measurement time is set shorter, then in the case of blood concentration measurement with a high glucose concentration, sufficient color development required for accurate concentration measurement cannot be obtained, and in the high concentration region Decreased measurement accuracy
On the other hand, if it is necessary to ensure sufficient measurement accuracy while ensuring a short measurement time, the measurement range becomes smaller.
[0007] In addition, when the reagent part 95 contains an unstable reagent (highly reactive reagent) such as methoxy-PMS as the electron transfer substance, when the glucose sensor 9 is stored, the unstable reagent Reacts with other reagents, causing measurement errors.
Therefore, when a single reagent part is mixed with multiple reagents, the retention stability is poor due to the different combinations of these reagents, and the measurement accuracy deteriorates.

Method used

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  • Analyzing tool being reduced in distance of diffusion of reagent and method for manufacture thereof
  • Analyzing tool being reduced in distance of diffusion of reagent and method for manufacture thereof
  • Analyzing tool being reduced in distance of diffusion of reagent and method for manufacture thereof

Examples

Experimental program
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Effect test

no. 1 approach

[0051] First, a first embodiment of the present invention will be described.

[0052] Figure 1~ image 3 The glucose sensor X1 shown is designed as a disposable structure for the colorimetric determination of the glucose concentration. The glucose sensor X1 has a form in which rectangular first and second plate members 1 and 2 are joined via a pair of spacers 3 . The glucose sensor X1 has a capillary 4 defined by the members 1 to 3 .

[0053] The first and second boards 1 and 2 are made of, for example, PET, PMMA, or vinylon to be transparent. The first and second reagent parts 51 and 52 are provided on these plates 1 and 2 in a state of being housed inside the capillary 4 . Each of the reagent parts 51 and 52 is formed in a solid form that is easily dissolved in blood, and at least one of these reagent parts 51 and 52 contains a coloring agent. Therefore, when blood is introduced into the capillary 4 , a liquid-phase reaction system containing glucose and a chromogenic ag...

no. 2 approach

[0081] Next, a second embodiment of the present invention will be described. Note that, in this embodiment, when referring to the drawings, the same reference numerals are assigned to the same parts as those described in the first embodiment above.

[0082] The glucose sensor X7 shown in Figures 11 to 14 is a disposable structure for measuring glucose concentration by colorimetry, and its basic structure is the same as that of the glucose sensor X1 described above (Figures 1 to 14). image 3 )same. That is, the glucose sensor X7 has a form in which the first and second plates 1, 2 are joined by a pair of spacers 3F, and the first and second plates 1, 2 are connected in the longitudinal direction of the first and second plates 1, 2 through each member 1, 2, 3F. An extended capillary 4F is defined.

[0083] In the glucose sensor X7, the height dimension H' of the capillary 4F and the arrangement of the reagent part 51F are the same as those of the glucose sensor X1 (Figs. im...

no. 1 example

[0098] In this embodiment, when blood is used as a sample, the effect of the height dimension (opposite distance) of the capillary in the glucose sensor on the measurement time is studied by measuring the temporal change of absorbance.

[0099] (glucose sensor used in this example)

[0100] In this embodiment, three kinds of glucose sensors (1) to (3) are used. These glucose sensors (1) to (3) basically have the same structure, and by specifying the thickness dimension of the double-sided tape (spacer), as shown in Table 1, the height dimension (opposite distance) of the capillary is different from each other. .

[0101]Each glucose sensor (1)-(3) was manufactured as follows. First, a pair of double-sided tapes was attached to a first transparent plate made of PET having a size of 10 mm×30 mm×0.2 mm at a distance of 3 mm. The double-sided tape specifies the thickness dimension of the capillary, and the thickness of the double-sided tape used for each glucose sensor (1) to (...

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Abstract

An analyzing tool (X1) which has a reaction space (4) for reacting a specific component in a sample with a reagent, and a reagent section (51, 52) being arranged in the reaction space (4) and being dissolved when the sample is supplied to the reaction space (4), wherein the reagent section (51, 52) comprises a first portion (51) and a second portion (52) which are opposed to each other in the face specifying the reaction space (4).

Description

technical field [0001] The present invention relates to an analysis tool used for analyzing a specific component in a sample and a method for manufacturing the same. Background technique [0002] As an analysis tool used to measure a blood sugar level by colorimetry, there is, for example, a glucose sensor 9 shown in FIG. 20 . The glucose sensor 9 has a form in which the first and second plates 91 and 92 are joined via a pair of spacers 93 . This glucose sensor 9 has a capillary 94 defined by the above-mentioned members 91 to 93 . Inside the capillary 94 there is a reagent section 95 . The reagent part 95 dissolves when supplied with blood, and is constituted as a composition containing reaction components such as a chromogenic agent, an oxidoreductase, and an electron transport substance. [0003] In such a glucose sensor 9 , when blood is introduced through the opening 96 , the blood introduced into the capillary 94 moves toward the opening 97 by the capillary force gen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00G01N33/52G01N33/48G01N1/00G01N21/03G01N21/77G01N21/78
Inventor 永川健儿寺元正明川濑喜幸星岛光博
Owner ARKRAY INC