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Use of pirfenidone for treating psoriasis

A technology of pirfenidone and psoriasis, which is applied in the field of new drugs for the treatment of psoriasis, and can solve the problems that there is no pirfenidone to treat psoriasis.

Inactive Publication Date: 2006-05-24
徐旗开
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, so far, there is no report on the use of pirfenidone for the treatment of psoriasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 pirfenidone tablet

[0017] Ingredients Dosage (mg / tablet)

[0018] Pirfenidone 500mg

[0019] Microcrystalline Cellulose 430mg

[0020] Colloidal silicon dioxide 20mg

[0021] Stearic acid 10mg

[0022] The above ingredients were mixed and compressed into tablets, each weighing 1000mg.

Embodiment 2

[0023] Example 2 Pirfenidone Capsules

[0024] Ingredients Dosage (mg / capsule)

[0025] Pirfenidone 400mg

[0026] Starch 295mg

[0027] Magnesium Stearate 5mg

[0028] The above ingredients were mixed and filled into gelatin capsules, each weighing 700 mg.

[0029] Similar to this, according to conventional methods in the art, various oral preparations containing pirfenidone can be prepared, such as solutions, granules, powders, syrups, mixtures, etc. Suspension, etc.

Embodiment 3

[0030] Embodiment 3 pirfenidone lotion

[0031] Ingredients Content

[0032] Pirfenidone Powder 20g

[0033] water 650g

[0034] Ethoxydiglycol 230g

[0035] Glyceryl Dilaurate 60g

[0036] Propylene Glycol Dicaprylate 40g

[0037] Preparation

[0038] After the above-mentioned components are fully dissolved in water, 1000g of pirfenidone lotion is obtained.

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PUM

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Abstract

The present invention relates to an application of pyrifenidone in preparation of medicine for curing psoriasis. It can be oral administration or used for external application.

Description

technical field [0001] The present invention relates to a new drug for treating psoriasis; specifically, the present invention relates to a new medicinal use of pirfenidone, 5-methyl-1-phenyl-2-(1H)-pyridone. More specifically, the present invention relates to the application of pirfenidone in the preparation of medicines for treating psoriasis. Background technique [0002] Psoriasis is a skin disease characterized by keratosis of the epidermis. Psoriasis occurs when new skin cells form in the lower epidermis and the new skin moves to the upper epidermis faster than the old skin cells can be shed on the epidermis. As a result of the above and other mechanisms, inflamed and thickened skin papules and spots covered by sheets of dead skin layers (ie, scales) develop. Symptoms of psoriasis thus include abnormal redness (ie, erythema) and induration due to inflammation, and possibly silvery and laminated scales. Psoriasis usually occurs on the scalp and the extensor surfaces ...

Claims

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Application Information

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IPC IPC(8): A61K31/44A61K9/20A61K9/48A61P17/06
Inventor 徐旗开
Owner 徐旗开
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