Methods for treating protein aggregation disorders

A technology for protein aggregation and disease, which is applied to nervous system diseases, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as no disease treatment drug treatment methods
CN1838950AInactive Publication Date: 2006-09-27NEUROCHEM INT
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NEUROCHEM INT
Publication Date
2006-09-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is based, at least in part on the discovery of therapeutic agents capable of preventing, inhibiting or modulating abnormal processing, misfolding or aggregation of protein. The therapeutic agents of the invention may prevent, inhibit or modulate the formation of inclusions. The therapeutic agents of the invention may also be capable of facilitating clearance and / or blocking the cellular toxicity of inclusions to treat or ameliorate disorders characterized by protein aggregation. Compounds which bind to structural motifs commonly found in protein aggregates, such as ss-sheets, would represent strong candidates for such compounds and are therefore desirable.
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Description

[0001] related application

[0002] This application claims the benefits of U.S. Provisional Patent Application 60 / 480,918, filed June 23, 2003, U.S. Provisional Application 60 / 512,017, filed October 17, 2003, and U.S. Application 10 / ____,____, filed June 18, 2004 Priority, the titles of the above three applications are "Methods for Treating Protein Aggregation Disorders" (Methods for Treating Protein Aggregation Disorders).

[0003] This application is related to U.S. Provisional Patent Application 60 / 480,984, filed June 23, 2003, U.S. Provisional Patent Application 60 / 512,116, filed October 17, 2003, and U.S. Application 10 / ____,____, filed June 18, 2004 (Docket No. NBI-152), entitled "Pharmaceutical Formulations of Amyloid-Inhibiting Compounds."

[0004] This application is related to U.S. Provisional Application 60 / 482,214, filed June 23, 2003, and U.S. Provisional Application 60 / 436,379, filed December 24, 2002, entitled "Combination Therapy for Alzheim...

Claims

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