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Light emitting diode based measurement systems

A technology of light-emitting diodes and measurement systems, applied in the field of measurement systems, can solve the problems of expensive optical devices, unsatisfactory beam shape, and increased manufacturing complexity of flow cytometers.

Active Publication Date: 2006-10-11
LUMINEX
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such optics are expensive and add to the manufacturing complexity of the flow cytometer
Furthermore, even when using expensive and complex beam-shaping optics, the resulting beam profile is still not satisfactory (e.g., 10% to 15% variation in energy intensity across the flow path)

Method used

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  • Light emitting diode based measurement systems
  • Light emitting diode based measurement systems
  • Light emitting diode based measurement systems

Examples

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Embodiment Construction

[0031] Although the embodiments described herein relate to microspheres or polystyrene beads, it should be understood that microparticles, beads, microbeads, latex particles, latex beads, fluorescent beads, fluorescent particles, colored particles, colored beads and cells. Microspheres can be used as vehicles for molecular reactions. Examples of suitable microspheres, beads and particles are found in U.S. Patent No. 5,736,330 to Fulton, U.S. Patent No. 5,981,180 to Chandler et al., U.S. Patent No. 6,057,107 to Fulton, U.S. Patent No. 6,268,222 to Chandler, U.S. Patent No. 6,449,562 to Chandler US Patent No. 6,514,295 to Chandler et al., US Patent No. 6,524,793 to Chandler et al., and US Patent No. 6,528,165 to Chandler et al., which are incorporated herein by reference as if fully set forth. The measurement systems and methods described herein can also use any of the microspheres, beads and particles described in these patents. Additionally, microspheres for use in flow cyto...

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PUM

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Abstract

Various light emitting diode (LED) based measurement systems and methods are provided. A system includes an array of one or more LEDs (14, 16, 18) arranged along a flow path (20) of a sample (10). The array is configured to illuminate the sample as the sample moves along the flow path. The system also includes one or more detectors (24) configured to detect light produced by the array illuminating the sample. One method involves irradiating microspheres at different locations along their flow paths. The method also includes detecting light produced by the illumination to generate separate output signals corresponding to the illumination at different locations. The method also includes combining the discrete output signals to produce a single output signal having a signal-to-noise ratio greater than the signal-to-noise ratio of the discrete output signals.

Description

technical field [0001] The present invention generally relates to measurement systems based on light emitting diodes. Certain embodiments relate to measurement systems that include one or more light emitting diodes arrayed along the flow path of microspheres or other fluorescence emitting samples. Background technique [0002] Typically, flow cytometers provide measurements of the intensity of fluorescence excited by a laser on polystyrene beads or cells as they pass linearly through the flow chamber. However, flow cytometers can also be used to provide measurements of one or more properties of other particles. Some systems are configured to measure light energy levels scattered by particles at 90 or 180 degrees from the excitation source, two or more measurements of fluorescence to determine classification as particle "identity", and human Additional measurements called "reporters" are often used to verify the chemical reaction of interest. Each of the fluorescence measu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/14
CPCG01N15/1434
Inventor W·D·罗斯
Owner LUMINEX
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