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6,7-dehydroxyleanone in salvia farinacea root with platelet aggregation inhibition

A technology for dehydrorolitone and platelet aggregation, which is used in medical preparations containing active ingredients, blood diseases, organic chemistry, etc.

Inactive Publication Date: 2006-10-25
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when activated, platelet membrane receptor binding sites are exposed and bind to fibrinogen leading to aggregation

Method used

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  • 6,7-dehydroxyleanone in salvia farinacea root with platelet aggregation inhibition
  • 6,7-dehydroxyleanone in salvia farinacea root with platelet aggregation inhibition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1 Preparation and separation process of 6,7-dehydroroglitazone: see Figure 1.

Embodiment 2

[0008] Embodiment 2 6, the NMR spectrum data of 7-dehydroroglitazone

[0009] Red needle-like crystal (ethanol), mp170-171℃, soluble in benzene, chloroform and other low-polarity organic solvents.

[0010]

[0011] 1 H-NMR (500Hz, CDCl 3 ):

[0012] δ6.81 (1H, dd, J=9.5, 3, 7-H)

[0013] δ6.47 (1H, dd, J=9.5, 3, 6-H)

[0014] δ3.17 (1H, hept, J=10.8, 15-H)

[0015] δ2.89 (each 1H, d, J=13.5, 1-H)

[0016] δ2.14 (1H, t, J=3.25, 5-H)

[0017] δ1.22 (3H, d, J=10.8, 16-H)

[0018] δ1.23 (3H, d, J=10.8, 17-H)

[0019] δ0.98(3H, s, 18-H)

[0020] δ1.02 (3H, s, 19-H)

[0021] δ1.04 (3H, s, 20-H)

Embodiment 3

[0022] Example 3 Inhibition of platelet aggregation by 6,7-dehydroroolitazone

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Abstract

This invention relates to distill restraining blood platelet agglomeration from Xinjiang sage preparation method and pharmacodynamics experiment. The result reveals that comparing to normal saline, 6, 7-dehydrogenation enumerates ketone 2mg / ml group blood platelet restrain ratio is 56.2 percent, and 1mg / ml group blood platelet restrain ratio is 49.7 percent. So 6, 7-dehydrogenation enumerate ketone or extract contains it has good application of restrain blood agglomeration function and in anti cardiovascular diseases.

Description

technical field [0001] The invention relates to a method for extracting effective ingredients for inhibiting platelet aggregation from the root of the plant Sage sageii and its medicinal application. Background technique [0002] The principle of platelet aggregation: the mutual adhesion between platelets and platelets, and the aggregation into clumps is platelet aggregation. It is generally believed that its simple model is: platelet membrane receptor-connexin (regulatory protein)-platelet membrane receptor. The platelet membrane receptor is a glycoprotein complex, the connecting protein is fibrinogen, and the regulatory protein is thrombospondin or fibronectin or von Willebrand factor. Under resting conditions, 90% of platelets exist in complex form. However, when activated, platelet membrane receptor binding sites are exposed and bind to fibrinogen leading to aggregation. [0003] Xinjiang sage (Salvia deserta Schang), also known as Xinjiang D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/613A23L33/105A61K31/122A61P7/02A61P9/00
Inventor 热娜·卡斯木哈木拉提·吾甫尔堵年生王怀安王新玲王晓梅杨建
Owner XINJIANG MEDICAL UNIV
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