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Application of Qishen Yiqi dripping pills for preparing medicine to inhibit leakage of albumin

A technology of Qishen Yiqi dripping pills and albumin, applied in the field of medicine, can solve problems such as anti-leakage of albumin in venules

Active Publication Date: 2006-11-15
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN1375316A discloses the composition, preparation method and application of the preparation in angina pectoris of coronary heart disease, but the effect of the drug in anti-albumin leakage in fine veins and improvement of microcirculation has not been reported yet

Method used

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  • Application of Qishen Yiqi dripping pills for preparing medicine to inhibit leakage of albumin
  • Application of Qishen Yiqi dripping pills for preparing medicine to inhibit leakage of albumin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 86.5g of astragalus, 21.3g of salvia miltiorrhiza, 3.5g of notoginseng, 20.6g of jiangxiang, and 30g of polyethylene glycol-6000 as an auxiliary material. Decoct the crushed salvia miltiorrhiza and Panax notoginseng in water twice, adding 7 times the amount of water each time for 2 hours each time, combining the decoction liquid, filtering, and concentrating the filtrate to 900ml, adding 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, recover ethanol, concentrate into an extract with a relative density of 1.32-1.38 (50-60°C); decoct the pulverized Astragalus membranaceus twice with water, adding 6 Double the amount of water, extract for 2 hours and 1 hour in turn, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and concentrate to about 400ml , add 95% ethanol to make the alcohol c...

Embodiment 2

[0040]Get Astragalus 40.6g, Salvia miltiorrhiza 44.8g, Panax notoginseng 11.2g, Dalbergia 38.6g, adjuvant polyethylene glycol-6000 30g, according to the preparation process of embodiment 1, make the traditional Chinese medicine preparation of the present invention.

Embodiment 3

[0042] Get 77.3g of Radix Astragali, 22.8g of Salvia miltiorrhiza, 4.8g of Radix Notoginseng, 30.5g of Jiangxiang, and 28g of polyethylene glycol-6000 as an auxiliary material, and make the traditional Chinese medicine preparation of the present invention according to the preparation process of Example 1.

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Abstract

An application of the 'Qi-replenishing' Qishen dripping pill in preparing the medicines for preventing and treating the microcirculatory disturbance diseases caused by albumin leakage is disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Qishen Yiqi dripping pills in the preparation of medicines for inhibiting albumin leakage in fine veins. Background technique [0002] Salvia miltiorrhiza has preventive and therapeutic effects on microcirculation disturbance caused by ischemia-reperfusion. Its mechanism of action includes protecting vascular endothelial cells, removing superoxide, inhibiting the adhesion of leukocytes to vascular endothelium, inhibiting mast cell degranulation, and inhibiting the leakage of albumin in venules. Salvia miltiorrhiza plays a role in the prevention and treatment of microcirculation disturbance caused by ischemia-reperfusion through its multi-link and multi-target comprehensive effects on microcirculation. However, in the prevention and long-term treatment of cardiovascular and cerebrovascular diseases, the need for intravenous administration of Danshen is limit...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61P9/00A61P43/00
Inventor 韩晶岩李旭郑永锋叶正良
Owner TIANJIN TASLY PHARMA CO LTD
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