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Compound gel of rhinitis, and preparation method

A technology for rhinitis and gel, which is applied in the field of compound rhinitis gel, which can solve the problems of small nasal mucosa contact area, reduced drug efficacy, and poor packaging, and achieve the effects of less adverse reactions, increased local concentration, and good stability

Inactive Publication Date: 2006-12-06
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ointment is squeezed into the nasal cavity in strips, and the contact area with the nasal mucosa is small, so it is often difficult to absorb or incompletely absorbed
Made into oral preparations, due to the influence of the first-pass effect of the liver, the efficacy of the drug will be reduced
Aerosols require pressure-resistant containers and valve systems, and sometimes fail due to the penetration of propellants due to poor packaging

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh the following ingredients:

[0027] Andrographis paniculata concentrate 150g, goose not herb concentrate 25g, ephedrine hydrochloride 5g, diphenhydramine hydrochloride 1.5g, peppermint oil 10ml, eucalyptus oil 10ml, carbomer 10g, propylene glycol 150g.

[0028] Mix and stir ephedrine hydrochloride fine powder, diphenhydramine hydrochloride, andrographis paniculata concentrate and goose non-grass concentrate, and set aside; mix peppermint oil and eucalyptus oil (add 10g ethanol to dissolve), set aside; dissolve carbomer Swell in water for more than 24 hours, adjust the pH to 5-8 with triethanolamine, add propylene glycol, stir evenly, add water to 1000g, and obtain.

Embodiment 2

[0030] Weigh the following ingredients:

[0031] 150g of Andrographis paniculata concentrate, 25g of Goose Bubivory concentrate, 5g of ephedrine hydrochloride, 1.5g of diphenhydramine hydrochloride, 10ml of peppermint oil, 10ml of eucalyptus oil, 5g of carboxymethylcellulose, and 50g of propylene glycol.

[0032] Mix and stir ephedrine hydrochloride fine powder, diphenhydramine hydrochloride, Andrographis paniculata concentrate and goose not herbivorous concentrate, and set aside; mix peppermint oil and eucalyptus oil (add 50g ethanol to dissolve), set aside; carboxymethyl cellulose Dissolve sodium plain in water and swell for more than 24 hours, adjust pH to 5-8 with sodium hydroxide, add propylene glycol, stir evenly, add water to 1000g, and obtain.

Embodiment 3

[0034] Weigh the following ingredients:

[0035] 150g of Andrographis paniculata concentrate, 25g of Goose Bubivora concentrate, 5g of ephedrine hydrochloride, 1.5g of diphenhydramine hydrochloride, 10ml of peppermint oil, 10ml of eucalyptus oil, 15g of gelatin, 200g of glycerin.

[0036] Mix and stir ephedrine hydrochloride fine powder, diphenhydramine hydrochloride, andrographis paniculata concentrate and goose non-grass concentrate, and set aside; mix peppermint oil and eucalyptus oil evenly (add 150g of ethanol to dissolve), set aside; dissolve gelatin in water Swell for more than 24 hours, adjust the pH to 5-8 with sodium hydroxide, add glycerin and stir evenly, add water to 1000g, and get ready.

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PUM

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Abstract

A medicine in the form of gel for treating rhinitis is prepared from ephedrine hydrochloride, benadryl hydrochloride, and the concentrated liquid extracts of green chiretta and small centripeda herb through dissolving in water, filtering, stirring, adding mint oil and eucalyptus oil, stirring, adding triethanolamine or sodium hydroxide or ammonia water to regulate pH value, adding humectant, adding water and stirring.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine prescription preparations, and specifically relates to a compound rhinitis gel and a preparation method thereof. Background technique [0002] Traditional Chinese medicine preparations for the treatment of rhinitis generally adopt the route of oral administration, and some are made into nasal drops, aerosols, sprays, ointments, etc. The ointment is squeezed into the nasal cavity in strips, and the contact area with the nasal mucosa is small, so it is often difficult or incomplete to absorb. Made into oral preparations, due to the influence of the liver's first-pass effect, the curative effect of the drug will be reduced. Aerosols require pressure-resistant containers and valve systems, and sometimes fail due to poor packaging that allows penetration of the propellant. Contents of the invention [0003] The object of the present invention is to provide a compound rhinitis gel which i...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/00A61P11/02A61K31/137A61K31/138
Inventor 董大伦
Owner GUIYANG XINTIAN PHARMA CO LTD
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