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Hypericum perforatum L. phenolic acid and injection thereof preparation method

A technology of Hypericum perforatum and myroic acid is applied in the directions of medical preparations, pharmaceutical formulations, antiviral agents, etc. containing active ingredients, which can solve the problems of not achieving ideal effects, large toxic and side effects, and many adverse reactions, and achieves toxic effects. The effect of small side effects and adverse reactions, fast drug effect and high blood drug concentration

Inactive Publication Date: 2006-12-27
四川三民药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the medicine for the treatment of viral hepatitis has not achieved the desired effect at present, either the effect is not good enough or the toxic and side effects are large or the adverse reactions are many.

Method used

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  • Hypericum perforatum L. phenolic acid and injection thereof preparation method
  • Hypericum perforatum L. phenolic acid and injection thereof preparation method
  • Hypericum perforatum L. phenolic acid and injection thereof preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0033] Example A Small-capacity Hypericin Injection

[0034] Example 1 consists of 25mg of hypericin and adding water for injection to 10ml.

[0035] Example 2 consists of 50 mg of hypericin and adding water for injection to 20 ml.

[0036] The large-capacity hypericin sodium chloride injection is prepared as a finished product by the following method: take 25-50 mg of hypericin, add 0.9% (w / v) sodium chloride of the total amount of the injection, and add the prescribed amount About 20% water for injection, adjust the pH value to about 7.0, heat to boil, add 0.3% (w / v) activated carbon to absorb for about 10 minutes, filter and decarbonize, add water for injection to the full amount, adjust the pH value to about 7.0, fine filter and clarify, After passing the inspection of the semi-finished product, it is filled and sealed in a 50-100ml infusion bottle, sterilized, inspected by light, labeled, inspected for the finished product, and packaged.

Embodiment B

[0037] Example B Large-capacity hypericin sodium chloride injection

[0038] Example 1 consists of 25 mg of hypericin, 0.45 g of sodium chloride, and 50 ml of water for injection.

[0039] Example 2 consists of 50 mg of hypericin, 0.9 g of sodium chloride, and 100 ml of water for injection.

[0040] Hypericin for injection (freeze-dried powder injection) is prepared according to the following method: take hypericin 25-50 mg, mannitol or xylitol or sorbitol or dextran 75-100 mg, add About 60% of the prescription water for injection, adjust the pH to about 7.0, heat to boil, add adsorbent for about 10 minutes, filter to remove the adsorbent, add water for injection to 2-3ml, use composite micropores composed of 0.45um and 0.22um Sterilize by filter membrane, put it into a sterilized 7-10ml freeze-dried bottle under aseptic conditions, freeze-dry after pre-freezing, make 0.1-0.15g freeze-dried powder injection, seal, label, finished product inspection, packaging Instantly.

Embodiment C

[0041] Example C Hyperforic acid for injection (freeze-dried powder injection)

[0042] Example 1 Add 25 mg of hypericin and 75 mg of mannitol to 2 ml of water for injection to make 0.10 g / bottle of freeze-dried powder injection.

[0043] Example 2 Hypericin perforatin 50mg, xylitol 100mg, water for injection added to 3ml, made into 0.15g / bottle of freeze-dried powder injection.

[0044] Example 3 Add 50 mg of hypericin and 75 mg of sorbitol to 2 ml of water for injection to make 0.10 g / bottle of freeze-dried powder injection.

[0045] Example 4 Add 50 mg of hypericin and 75 mg of dextran to 2 ml of water for injection to make 0.10 g / bottle of freeze-dried powder injection.

[0046] Example 5 Hypericin 50mg, mannitol 100mg, water for injection added to 3ml, made into 0.15g / bottle of freeze-dried powder injection.

[0047] Example 6 Add 50 mg of hypericin, 100 mg of xylitol, and 3 ml of water for injection to make 0.15 g / bottle of freeze-dried powder injection.

[0048] Exam...

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PUM

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Abstract

The invention discloses a extractive method of hyperforin phenolic acid and preparation method of hyperforin phenol acid injection. The hyperforin phenolic acid is consisted of total phenolic acid of more than 95 % and total hypericin of 1.2 %. The extraction method of the hyperforin phenolic acid is characterizing by: reflux extracting medicinal materials 3 times with 75 % ethanol, degreasing with ether, extracting with ethyl acetate, eluting D101 resin, which extraction is absorbed on, with ethanol of 40 % and 80 %, concentrating residual liquid and eluent of 40 %, separating by column chromatogram of polyamide, extracting by ethyl acetate, drying, getting phenolic acid extract and mixing with dry matter of 80 % ethanol eluent to prepare hyperforin phenolic acid (intermediate). The injection is prepared of intermediate, medicinal assistant material and water for injection, and can produce to small injection, transfusion agent and freezing-dried powder injection. The injection has high bioavailability, high concentration of blood and medicine, quick effect, and exact curative effect for curing depression, virus A and B hepatitis.

Description

Technical field: [0001] The invention relates to a preparation method of effective part hypericin extracted from Hypericum perforatum medicinal material and an injection thereof, belonging to the technical field of traditional Chinese medicine. The invention has the functions of protecting the liver, soothing the liver and relieving stagnation, and has the effect of antiviral hepatitis, and is mainly used for treating depression caused by emotional discomfort, stagnation of qi, and hepatitis A and B caused by hepatitis virus invasion. viral hepatitis. Background technique: [0002] Depression, from the perspective of traditional Chinese medicine, it belongs to the category of "depression". Depression is caused by emotional discomfort and stagnation of qi. The disease is caused by the seven emotional factors such as depression, anger, worry, sadness, and sorrow, resulting in poor emotion and stagnation of qi. Zhu Zhenheng, a famous doctor in the Yuan Dynasty, pointed out in...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/122A61K9/19A61K9/08A61P25/24A61P31/14A61P31/20A61P1/16
Inventor 罗明生
Owner 四川三民药业有限公司
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