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Compound medicine composition and its prepn and use

A composition and drug technology, applied in the field of antipyretic, analgesic and anti-inflammatory drugs for livestock and poultry, can solve the problems of slow action, short action time, easy rebound of antipyretic effect, etc.

Active Publication Date: 2007-01-03
BEIJING DABEINONG ANIMAL HEALTH TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing antipyretic drugs have slow action and short action time, and the antipyretic effect is easy to rebound, which cannot meet the clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] Diclofenac Sodium 2g

[0024] Naproxen 4g

[0025] N-methyl-2-pyrrolidone 60ml

[0026] Antioxidant amount

[0027] Add water for injection to 100ml

[0028] Preparation:

[0029] 1. Take the prescribed amount of N-methyl-2-pyrrolidone, add diclofenac sodium, stir to dissolve; add naproxen, stir to dissolve.

[0030] 2. Take an appropriate amount of water for injection, add antioxidant, stir to dissolve.

[0031] 3. Combine 1 and 2, adjust the pH value to 5-8, dilute to 100ml with water for injection, and filter through a membrane.

[0032] 4. Potting, steam sterilization at 100°C for 30 minutes, ready to serve.

Embodiment 2

[0034] prescription:

[0035] Diclofenac Sodium 1g

[0036] Naproxen 10g

[0037] N-methyl-2-pyrrolidone 80ml

[0038] Antioxidant amount

[0039] Add water for injection to 100ml

[0040] Preparation:

[0041] 1. Take the prescribed amount of N-methyl-2-pyrrolidone, add diclofenac sodium, stir to dissolve; add naproxen, stir to dissolve.

[0042] 2. Take an appropriate amount of water for injection, add antioxidant, stir to dissolve.

[0043] 3. Combine 1 and 2, adjust the pH value to 5-8, dilute to 100ml with water for injection, and filter through a membrane.

[0044] 4. Potting, steam sterilization at 100°C for 30 minutes, ready to serve.

Embodiment 3

[0046] prescription:

[0047] Diclofenac Sodium 10g

[0048] Naproxen 1g

[0049] N-methyl-2-pyrrolidone 80ml

[0050] Antioxidant amount

[0051] Add water for injection to 100ml

[0052] Preparation:

[0053] 1. Take the prescribed amount of N-methyl-2-pyrrolidone, add diclofenac sodium, stir to dissolve; add naproxen, stir to dissolve.

[0054] 2. Take an appropriate amount of water for injection, add antioxidant, stir to dissolve.

[0055] 3. Combine 1 and 2, adjust the pH value to 5-8, dilute to 100ml with water for injection, and filter through a membrane.

[0056] 4. Potting, steam sterilization at 100°C for 30 minutes, ready to serve.

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PUM

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Abstract

The present invention relates to one kind of veterinary medicine composition for eliminating fever, relieving pain and diminishing inflammation and its preparation process and use. The veterinary medicine composition consists of diclofenac sodium and naproxen in the weight ratio of 0.1-10, preferably 0.2-5; or consists of diclofenac sodium and barbitone in the weight ratio of 0.2-10, preferably1-7.5. The veterinary medicine composition is used in preventing and treating feverish animal diseases and has synergistic fever eliminating effect, fast acting and less recurrence.

Description

technical field [0001] The invention belongs to antipyretic, analgesic and anti-inflammatory drugs for livestock and poultry, in particular to a compound pharmaceutical composition composed of diclofenac sodium, naproxen or barbiturate and a preparation method thereof. Background technique [0002] When livestock and poultry are attacked by bacteria, viruses, and mycoplasma, most of the clinical symptoms are accompanied by inflammatory symptoms (fever, pain), which affect the normal diet, activities and healthy growth of the demand. Therefore, whether it is from the perspective of animal welfare or animal production, anti-inflammatory (antipyretic, analgesic) is necessary while administering antibacterial and antiviral drugs. [0003] In my country, the prevention and control of livestock and poultry diseases is an important guarantee for the healthy development of animal husbandry. my country has a vast territory, different climates and production habits in different regio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/515A61K31/196A61K9/08A61P29/00
Inventor 田玲莫云刘彤郭致君王海良布仁阿古达木
Owner BEIJING DABEINONG ANIMAL HEALTH TECH
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