Medicine for treating gap and vomiting due to nuclear-radiation, radiotherapy and anti-motion sickness

A technique for nausea, vomiting, and motion sickness, applied in the digestive system, drug combination, aerosol delivery, etc., can solve unrealistic problems such as unfavorable preparation, use, transportation, and storage, and achieve effective anti-dizziness effects, overcome drowsiness, strong synergistic effect

Inactive Publication Date: 2007-01-31
胡冠时
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the high temperature in the Taiwan Strait, it is unrealistic to use, tr...

Method used

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  • Medicine for treating gap and vomiting due to nuclear-radiation, radiotherapy and anti-motion sickness

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Example 1: main drug: a mixture of ondansetron hydrochloride and scopolamine: 2g, auxiliary drugs: cyclodextrin: 7g, polyethylene glycol 400: 11g, white petrolatum: 6g, liquid paraffin: 6g, stearic acid: 4g, Cetyl alcohol: 4g, Span 60: 4g, appropriate amount of water to 100g.

[0019] Preparation method: Weigh white vaseline: 6g, liquid paraffin: 6g, stearic acid: 4g, cetyl alcohol: 4g and Span 60: 2g, mix well, and heat and stir to form a colorless and clear liquid as liquid A for later use; Then weigh the mixture of ondansetron hydrochloride and scopolamine: 2g, add it to water, then add cyclodextrin: 7g, stir to dissolve it into a colorless and clear solution, then add a part of polyethanol 400:11g and Span 60:2g After dissolving, it becomes liquid B; at this time, heat liquid A again, add liquid B while stirring to form a uniform emulsion, cool, stir to make the emulsion into a fine cream, and then pack it into the warehouse.

Embodiment 2

[0020] Example 2: main drug: ondansetron hydrochloride: 4g, auxiliary drug: cyclodextrin: 8g, polyethylene glycol 400: 9g, white petrolatum: 4g, liquid paraffin: 7g, stearic acid: 6g, stearyl alcohol: 6g, Tween 80: 6g, appropriate amount of water to 100g.

[0021] Preparation method: Weigh white vaseline: 4g, liquid paraffin: 7g, stearic acid: 6g, stearyl alcohol: 6g and Tween 80: 3g, mix well, and heat and stir to form a colorless and clear liquid as liquid A for later use; Then weigh ondansetron hydrochloride: 4g and add it to water, then add cyclodextrin: 8g, stir to make it dissolve into a colorless and clear solution, then add a part of polyethanol 400: 9g and Tween 80: 3g, and dissolve immediately It is liquid B; at this time, heat liquid A again, add liquid B while stirring to form a uniform emulsion, cool, stir to make the emulsion into a fine cream, and then pack it into the warehouse.

Embodiment 3

[0022] Example 3: main drug: scopolamine: 0.5g, auxiliary drug: cyclodextrin: 3g, polyethylene glycol 400: 14g, white petrolatum: 3g, liquid paraffin: 5g, stearic acid: 5g, stearyl alcohol: 7g, department Plate 60: 5g, appropriate amount of water to 100g.

[0023] Preparation method: Weigh white vaseline: 3g, liquid paraffin: 5g, stearic acid: 5g, cetyl alcohol: 7g and Span 60: 2g, mix evenly, and heat and stir to form a colorless and clear liquid as liquid A for later use; Then weigh scopolamine: 0.5g and add it to water, then add cyclodextrin: 3g, stir to make it dissolve into a colorless and clear solution, then add a part of polyethanol 400:14g and Span 60:3g, and it will be liquid B after dissolution At this time, heat the liquid A again, add liquid B while stirring to form a uniform emulsion, cool, stir to make the emulsion into a delicate cream, and then pack it into the warehouse.

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Abstract

A medicine for treating the nausea and vomiting caused by nuclear radiation, radiotherapy, or chemicotherapy and the kinetosis with low by-effect is proportionally prepared from Endanxitong hydrochloride and/or scopolamine, cyclodextrin, polyethanol, white vaseline, atoleine, stearic acid, hexadecanol, span-60 and water.

Description

technical field [0001] The invention relates to an anti-nuclear radiation, anti-motion sickness drug and anti-tumor adjuvant treatment drug, specifically a medicament for treating nausea and vomiting caused by radiotherapy (nuclear radiation) and chemotherapy. Background technique [0002] The research of the U.S. Air Force Armstrong Laboratory on the antiemetic competitive 5-hydroxytryptamine 3 (5-HT3) receptor blocker ondansetron (ondansetron) showed that X-rays, γ-rays and neutron radiation induced Nausea and vomiting have a good preventive effect. Both drugs were well tolerated by healthy adults with no cognitive, psychomotor, and subjective sensory side effects. [0003] Anti-motion sickness drugs at home and abroad have adverse reactions that affect memory and behavior alertness. This adverse reaction will seriously affect the combat effectiveness of commanders and fighters. Since various sports environments can induce motion sickness, safe and effective anti-motion...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61K47/40A61K9/06A61P1/08A61K31/4178
Inventor 胡冠时毕云生
Owner 胡冠时
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