Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine for treating gap and vomiting due to nuclear-radiation, radiotherapy and anti-motion sickness

A technique for nausea, vomiting, and motion sickness, applied in the digestive system, drug combination, aerosol delivery, etc., can solve unrealistic problems such as unfavorable preparation, use, transportation, and storage, and achieve effective anti-dizziness effects, overcome drowsiness, strong synergistic effect

Inactive Publication Date: 2007-01-31
胡冠时
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high temperature in the Taiwan Strait, it is unrealistic to use, transport, and store in an environment below 37°C, which is not conducive to preparing for war.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine for treating gap and vomiting due to nuclear-radiation, radiotherapy and anti-motion sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: main drug: a mixture of ondansetron hydrochloride and scopolamine: 2g, auxiliary drugs: cyclodextrin: 7g, polyethylene glycol 400: 11g, white petrolatum: 6g, liquid paraffin: 6g, stearic acid: 4g, Cetyl alcohol: 4g, Span 60: 4g, appropriate amount of water to 100g.

[0019] Preparation method: Weigh white vaseline: 6g, liquid paraffin: 6g, stearic acid: 4g, cetyl alcohol: 4g and Span 60: 2g, mix well, and heat and stir to form a colorless and clear liquid as liquid A for later use; Then weigh the mixture of ondansetron hydrochloride and scopolamine: 2g, add it to water, then add cyclodextrin: 7g, stir to dissolve it into a colorless and clear solution, then add a part of polyethanol 400:11g and Span 60:2g After dissolving, it becomes liquid B; at this time, heat liquid A again, add liquid B while stirring to form a uniform emulsion, cool, stir to make the emulsion into a fine cream, and then pack it into the warehouse.

Embodiment 2

[0020] Example 2: main drug: ondansetron hydrochloride: 4g, auxiliary drug: cyclodextrin: 8g, polyethylene glycol 400: 9g, white petrolatum: 4g, liquid paraffin: 7g, stearic acid: 6g, stearyl alcohol: 6g, Tween 80: 6g, appropriate amount of water to 100g.

[0021] Preparation method: Weigh white vaseline: 4g, liquid paraffin: 7g, stearic acid: 6g, stearyl alcohol: 6g and Tween 80: 3g, mix well, and heat and stir to form a colorless and clear liquid as liquid A for later use; Then weigh ondansetron hydrochloride: 4g and add it to water, then add cyclodextrin: 8g, stir to make it dissolve into a colorless and clear solution, then add a part of polyethanol 400: 9g and Tween 80: 3g, and dissolve immediately It is liquid B; at this time, heat liquid A again, add liquid B while stirring to form a uniform emulsion, cool, stir to make the emulsion into a fine cream, and then pack it into the warehouse.

Embodiment 3

[0022] Example 3: main drug: scopolamine: 0.5g, auxiliary drug: cyclodextrin: 3g, polyethylene glycol 400: 14g, white petrolatum: 3g, liquid paraffin: 5g, stearic acid: 5g, stearyl alcohol: 7g, department Plate 60: 5g, appropriate amount of water to 100g.

[0023] Preparation method: Weigh white vaseline: 3g, liquid paraffin: 5g, stearic acid: 5g, cetyl alcohol: 7g and Span 60: 2g, mix evenly, and heat and stir to form a colorless and clear liquid as liquid A for later use; Then weigh scopolamine: 0.5g and add it to water, then add cyclodextrin: 3g, stir to make it dissolve into a colorless and clear solution, then add a part of polyethanol 400:14g and Span 60:3g, and it will be liquid B after dissolution At this time, heat the liquid A again, add liquid B while stirring to form a uniform emulsion, cool, stir to make the emulsion into a delicate cream, and then pack it into the warehouse.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A medicine for treating the nausea and vomiting caused by nuclear radiation, radiotherapy, or chemicotherapy and the kinetosis with low by-effect is proportionally prepared from Endanxitong hydrochloride and / or scopolamine, cyclodextrin, polyethanol, white vaseline, atoleine, stearic acid, hexadecanol, span-60 and water.

Description

technical field [0001] The invention relates to an anti-nuclear radiation, anti-motion sickness drug and anti-tumor adjuvant treatment drug, specifically a medicament for treating nausea and vomiting caused by radiotherapy (nuclear radiation) and chemotherapy. Background technique [0002] The research of the U.S. Air Force Armstrong Laboratory on the antiemetic competitive 5-hydroxytryptamine 3 (5-HT3) receptor blocker ondansetron (ondansetron) showed that X-rays, γ-rays and neutron radiation induced Nausea and vomiting have a good preventive effect. Both drugs were well tolerated by healthy adults with no cognitive, psychomotor, and subjective sensory side effects. [0003] Anti-motion sickness drugs at home and abroad have adverse reactions that affect memory and behavior alertness. This adverse reaction will seriously affect the combat effectiveness of commanders and fighters. Since various sports environments can induce motion sickness, safe and effective anti-motion...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/439A61K47/40A61K9/06A61P1/08A61K31/4178
Inventor 胡冠时毕云生
Owner 胡冠时
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com