Prepn. of mebendazole for treating adenoid hypertrophy

A technology of adenoid hypertrophy and mebendazole, which is applied in the field of application in the treatment of adenoid hypertrophy, to achieve the effect of relieving symptoms and relieving inflammatory symptoms

Inactive Publication Date: 2007-02-14
JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have not been any reports or literature records on the use of mebendazole in the treatment of chronic adenoid hypertrophy at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 mebendazole nasal cavity spray

[0017] In a 10,000-level environment, dissolve mebendazole in normal saline to prepare a 1 mg / ml solution, and add germine to make the concentration of geramine 0.02%. Fill this medicinal solution in a nasal cavity spray bottle, screw on the spray valve to obtain the mebendazole nasal cavity spray.

Embodiment 2

[0018] Example 2 Preparation of Mebendazole Nasal Aerosol

[0019] In a 10,000-level environment, dissolve mebendazole in normal saline to prepare a 1 mg / ml solution, and add germine to make the concentration of geramine 0.02%. Fill the medicinal solution in a nasal cavity aerosol bottle, add propellant, and install an aerosol valve to obtain the mebendazole nasal cavity aerosol.

Embodiment 3

[0020] The preparation of embodiment 3 mebendazole nasal cavity powder spray

[0021] In a 10,000-grade environment, mix 20 mg of mebendazole, 980 mg of hydroxypropyl cellulose (HPC), and 0.1 mg of benzalkonium chloride to obtain a uniform powder of 1 μg / mg of mebendazole, and the particle size of the powder should be 30 ~150 μm, filled into hard capsules to obtain mebendazole powder spray for nasal administration. When in use, it is sprayed into the nasal powder mist device for administration.

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PUM

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Abstract

A vermox in the form of spray, aerosol, powder spray and nose drops for treating adenoids is disclosed.

Description

technical field [0001] The present invention relates to use mebendazole to prepare spray, aerosol, powder spray and nasal drops, and these sprays, aerosol, powder spray and nasal drops containing mebendazole in the treatment of adenoid hypertrophy application. Background technique [0002] Adenoid hypertrophy is the hyperplasia of pharyngeal tonsils. Children's adenoid hypertrophy is often physiological. There are lymphoid tissues in the nasopharynx at birth, and they proliferate with age. They reach the maximum level at the age of 6 and gradually degenerate later. Called adenoid hypertrophy. [0003] 1. Etiology Childhood is prone to acute rhinitis, acute tonsillitis and influenza, etc. If repeated attacks, adenoids can rapidly proliferate and hypertrophy, resulting in aggravated nasal obstruction, hindering nasal drainage, rhinitis and sinusitis secretions stimulate adenoids Make it continue to proliferate, forming a vicious circle of mutual cause and effect. It is mor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K9/08A61K9/72A61K9/00A61P11/04A61P11/02A61P43/00
Inventor 郑文婕王鹤尧
Owner JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD
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