Ibuprofen medicinal preparation and preparing method thereof

Abstract

The invention relates to an analgesic-antipyretic ibuprofen pharmaceutical preparation and process for preparation, which comprises ibuprofen and medicinal supplementary materials, the medicament can be made into aerosol which comprises 0.8-10 weight portions of ibuprofen as raw material, 5-95 weight portions of medicinal auxiliary material, and 5-90 weight portions of casting agent.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical preparation of ibuprofen, an antipyretic and analgesic drug, and a preparation method thereof. Background technique [0002] Ibuprofen is an antipyretic and analgesic non-steroidal anti-inflammatory drug. At present, there are six dosage forms of ibuprofen products on the market in China, including oral solution, tablet, capsule, oral suspension (drop), syrup and liniment. Oral administration, digestive tract digestion and absorption, liver detoxification and other series of functional effects can only play its antipyretic and analgesic effect after entering the blood circulation. The dosage is 20mg~30mg once for adults. disadvantages, such as dose limitation in severe cases, slow action, irritation and damage to viscera, contraindication to visceral function, etc. At the same time, it will be accompanied by some adverse reactio...

AI Technical Summary

Problems solved by technology

At present, there are six dosage forms of ibuprofen products on the market in China, including oral solution, tablet, capsule, oral suspension (drop), syrup and liniment. Oral administration, digestive tract digestion and absorption, liver detoxification and other series of functional effects can only play its antipyretic and analgesic effect after entering the blood circulation. The dosage is 20mg~30mg once for adults. disadvantages, such as dose limitation in severe cases, slow action, irritation and damage to viscera, contraindication to visceral function, etc. At the same time, it will be accompanied by some adverse reactions, such as nausea, vomiting, stomach burning sensation or mild Indigestion, gastrointestinal ulcers and bleeding, elevated transaminases, headache, dizziness, tinnitus, blurred vision, nervousness, lethargy, edema or weight gain in the lower extremities, rare rash, allergic nephritis, cystitis, nephrotic syndrome, renal Nipple necrosis or renal failure, bronchospasm, etc.; ibuprofen liniment is more convenient, there is no contraindication and adverse reactions of oral medicine, and will not cause direct stimulation and damage to internal organs. This kind of external medicine is directly on the lesion The drug is applied on the epidermis of the affected area, absorbed through the capillaries of the affected area, and directly acts on the affected area to relieve fever and relieve pain, but the sealing performance is poor, secondary pollution is easy to occur, the drug administration is not uniform, and it is easy to cause pain to the patient. Analgesia is not fast, etc.