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Biosample manipulation device

A technology for biological samples and operating devices, which can be used in biochemical cleaning devices, enzymology/microbiology devices, microorganisms, etc., and can solve problems such as inability to inject cells, damage to cell nuclei, and cell death.

Inactive Publication Date: 2007-04-25
UNISOKU
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  • Abstract
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Problems solved by technology

[0004] However, in the conventional biological sample manipulation device 80, since it is necessary to fix the gene or the like to be introduced into the cell 84 at the tip of the needle 83, there is a problem that the cell cannot be 84 Injection or dripping of liquids such as genes or medicines or reactive gases dissolved in them
[0005] In addition, because the needle 83 with a diameter of about 10nm to 30nm is inserted into the cell, the opening on the cell membrane 85 is larger than the diameter of the needle 83 hole 86, in addition, sometimes the needle 83 brings damage to the nucleus 87
Therefore, there is also a problem that the cell 84 dies due to a large damage, or even if the hole 86 or the damage is repaired by the self-repair function of the cell 84, the repair takes a long time.

Method used

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Embodiment Construction

[0024] Hereinafter, a first embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a schematic diagram showing a biological sample manipulation device 1 according to the present embodiment. As shown in the figure, the biological sample manipulation device 1 is configured to include a unit for manipulating a cell (biological sample) 2 to be manipulated and observing the cell 2 at the same time. An atomic force microscope (hereinafter referred to as "AFM") 3 for surface change, a pulse power supply 4 for applying a pulse voltage to the AFM 3, a control unit 5 for controlling the operation of the AFM 3 and the pulse power supply 4, and an input and output unit for the control unit 5 A computer 6, and an optical microscope (operation observation unit) 7 for observing cell manipulation and internal changes of the manipulated cell 2. In addition, in the present embodiment, the cell 2 as an example of a biological sample is used for descripti...

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Abstract

Biosample manipulation apparatus (1) includes beam part (15) having its base end cantilevered; probe (17) secured in projecting form to the front end of the beam part (15) and having cavity (16) provided thereinside; minute hole (21) provided through the probe (17) so as to communicate the cavity (16) with outside of the probe (17); fluid (19) charged in the cavity (16); and fluid injection means (4, 12, 20) capable of not only effecting outflow of the fluid (19) through the minute hole (21) but also achieving injection thereof into biosample (2).

Description

technical field [0001] The present invention relates to a biological sample manipulating device for injecting or dripping a drug solution containing genes, proteins, enzymes, etc. into a biological sample such as cells, and more particularly to a biological sample manipulating device using a cantilever. Background technique [0002] Conventionally, in the fields of biological research, pathological research, etc., genes and the like are injected into cells to express them. Here, as a method of injecting a gene or the like into a biological sample such as a cell, a method using a cantilever provided in a scanning probe microscope has been used (refer to Patent Document 1). Fig. 8 is a diagram showing an example of a conventional biological sample manipulation device. As shown in the figure, the biological sample manipulation device 80 is provided with a cantilever 82 and a needle 83, wherein the cantilever 82 is arranged in a scanning probe microscope not shown, and a sharp-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/42C12N15/09C12N5/06C12N5/10C12M3/00C12N5/071
CPCC12M35/02
Inventor 长村俊彦
Owner UNISOKU
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