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Chinese drugs compound preparation for treating asthma and its preparation method

A compound preparation, a technology for asthma, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems that patients cannot effectively prevent recurrence, only pay attention to anti-asthma, and have unsatisfactory effects.

Inactive Publication Date: 2007-05-02
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medicine believes that asthma is a chronic airway inflammation involving eosinophils, mast cells, T lymphocytes and other inflammatory cells. Therefore, Western medicine treatment mainly focuses on anti-inflammatory and antispasmodic agents. The market mainly uses corticosteroid inhalants. , adrenaline inhalers, other asthma inhalants, systemic epinephrine and other Western medicines are dominant. Although these drugs have a relatively rapid effect and are easy to relieve symptoms in patients with acute attacks, they "only treat the symptoms, not the root cause". Only pay attention to asthma relief, but chronic eosinophilic bronchial inflammation, which is the root cause of asthma recurrence, has not been eliminated. As long as an allergen is encountered at any time, asthma will definitely be induced, and the relapse cannot be effectively prevented for patients in the remission period, so the effect is not ideal and there is a certain risk. side effects of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Example 1: Epimedium 1 part Morinda officinalis 1 part Houttuynia cordata 1 part

[0099]Take Epimedium medicinal materials, add 8 times the volume of 70% ethanol and reflux for 3 times, 1 hour each time, combine the extracts, and recover the ethanol under reduced pressure to 60℃. The relative density is determined to be 1.05~1.15. Add 4 times the volume of water. Dissolve, filter, and pass the filtrate through the polyamide column at a speed of 0.5ml / g medicinal material.min. Wash impurities with 7 times the volume of polyamide, then desorb with 5 times the volume of 60% ethanol. Collect the desorbed liquid and depressurize When the ethanol is recovered to 60°C, the relative density is determined to be 1.05~1.15, and the extract is dried to obtain the epimedium extract; take Morinda officinalis medicinal material, add 8 times the volume of 70% ethanol, reflux and extract 3 times, each time for 1 hour, combine the extracts, reduce The relative density is determined to be 1....

Embodiment 2

[0100] Example 2: 1 part of Epimedium, 99 parts of Morinda officinalis, 1 part of Houttuynia cordata

[0101] Take Epimedium medicinal materials, add 6 times the volume of 80% ethanol and reflux for extraction twice, 2.5 hours each time, combine the extracts, and recover the ethanol under reduced pressure to 60°C to determine the relative density to be 1.05~1.15, add 3 times the volume of water Dissolve, filter, and pass the filtrate through the polyamide column at a speed of 0.6ml / g medicinal material.min. Wash impurities with 8 times the volume of polyamide in turn, and then desorb with 4 times the volume of polyamide with 50% ethanol. Collect the desorbed liquid and recover under reduced pressure. The relative density is determined to be 1.05~1.15 when ethanol reaches 60℃, and the extract is dried to obtain Epimedium extract; Take Morinda officinalis medicinal material, add 10 times the volume of 60% ethanol to reflux and extract 4 times, each time for 1.0 hour, combine the ext...

Embodiment 3

[0102] Example 3: Epimedium 50 parts Morinda officinalis 50 parts Houttuynia cordata 50 parts

[0103] Take Epimedium medicinal materials, add 6 times the volume of 70% ethanol and reflux for 3 times, 1.5 hours each time, combine the extracts, and recover the ethanol under reduced pressure to 60℃. The relative density is determined to be 1.05~1.15. Add 4 times the volume of water to the medicinal materials. Dissolve, filter, and pass the filtrate through the polyamide column at a speed of 0.5ml / g medicinal material.min. Wash impurities with 5 times the volume of polyamide in turn, and then desorb with 6 times the volume of polyamide with 40% ethanol. Collect the desorbed liquid and recover it under reduced pressure. The relative density is determined to be 1.05~1.15 when ethanol is at 60℃, and the extract is obtained by drying. Take Morinda officinalis medicinal material, add 6 times volume of 70% ethanol and reflux for 4 times, each time for 1.0 hour, combine the extracts and red...

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PUM

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Abstract

A composite medicine in the form of injection or orally taken solid or liquid for treating asthmatic chronic bronchitis, acute bronchal asthma, lung infection, pneumonia, pneumonectasis, cardiogenic asthma, pulmonary tuberculosis, silicosis, etc is prepared from epimedium or its extract, indianmulberry root or its extract, and houttuynia or its extract. Its preparing process is also disclosed.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating asthma, and at the same time provides a preparation method of the compound preparation, and belongs to the technical field of traditional Chinese medicine. technical background [0002] Asthma is one of the most common chronic diseases in the world that is difficult to cure and recurs. There are about 160 million patients in the world. According to survey reports from several foreign countries, the prevalence of asthma in children is 0.2% to 7.4%, and the prevalence of asthma in adults is 1.1% to 9.9%. The prevalence of asthma in my country, according to local surveys, is about 0.5% to 2.0%, and it has also been reported as high as 5.29%. Asthma can occur at any age, and the incidence of adult men and women is roughly the same. With the continuous improvement of the degree of industrialization, due to the aggravation of air pollution and the development of the chemical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/16A61K9/12A61K9/20A61K9/48A61P11/06
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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