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Dispersion tablet of Glucurolactone, and preparation method

A technology of glucuronolactone and dispersible tablets, applied in the field of medicine, can solve problems such as inability to use, inconvenient application, etc., and achieve the effects of fast absorption, small adverse reactions and high bioavailability

Inactive Publication Date: 2007-05-09
TASLY HLDG GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucuronolactone injection, especially intravenous injection, must be carried out in hospitals and clinics under the operation of medical staff. It is very inconvenient to apply, and it cannot be used on the road, and injection, especially intravenous injection, is in the process of preparation. very strict

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, prescription: composition weight percent

[0034] Glucuron Lactone 20%

[0035] Appropriate amount of lactose

[0036] Sodium Starch Carboxymethyl 10%

[0037] Microcrystalline Cellulose 25%

[0038] Water (or ethanol solution) appropriate amount

[0039] Magnesium Lauryl Sulfate 3%

[0040] Preparation method: first crush the above materials through a 100-mesh sieve, fully mix glucuronolactone, lactose, sodium carboxymethyl starch microfine cellulose, and add appropriate amount of water (or ethanol solution) to make a soft material of 40 mesh After the granules are sieved, dry them, sieve the granules with 40 meshes, add magnesium lauryl sulfate and mix evenly, control the tablet weight, and press the tablets to obtain glucuronolactone dispersible tablets.

Embodiment 2

[0041] Embodiment 2, prescription: composition weight percent

[0042] Glucuron Lactone 50%

[0043] Appropriate amount of lactose

[0044]Pregelatinized Starch 10%

[0045] Microcrystalline Cellulose 17%

[0046] Low Substituted Hydroxypropyl Cellulose 7%

[0047] Proper amount of polyvinylpyrrolidone aqueous solution (calculated as polyvinylpyrrolidone)

[0048] Magnesium Stearate 1%

[0049] Preparation method: first crush the above materials through a 100-mesh sieve, fully mix glucuronolactone, lactose, pregelatinized starch, microfine cellulose, and low-substituted hydroxypropyl cellulose, and add an appropriate amount of polyvinylpyrrolidone aqueous solution to prepare Form soft material, dry after 20 mesh sieve, granulate with 20 mesh sieve, add magnesium stearate and mix evenly, control tablet weight, press tablet, obtain glucuronolactone dispersible tablet.

Embodiment 3

[0050] Embodiment 3, prescription: composition weight percent

[0051] Glucuron Lactone 35%

[0052] Microcrystalline Cellulose 20%

[0053] Lactose 20%

[0054] Appropriate amount of aspartame

[0055] Sodium Carboxymethyl Starch 5%

[0056] Aqueous solution of polyvinylpyrrolidone

[0057] Magnesium Stearate 1%

[0058] Proper amount of vanillin

[0059] Preparation method: first crush the above materials through a 100-mesh sieve, fully mix glucuronolactone, lactose, microfine cellulose, sodium carboxymethyl starch, aspartame, and vanillin, and add an appropriate amount of polyvinylpyrrolidone The aqueous solution is made into a soft material, dried after a 20-mesh sieve, granulated by a 20-mesh sieve, mixed with magnesium stearate, controlled for tablet weight, and pressed into tablets to obtain glucuronolactone dispersible tablets.

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PUM

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Abstract

A dispersing tablet of glucuronolactone is prepared from glucuronolactone (30-80 wt. %) and medical assistant (20-70wt. %) chosen from disintegrant, filler, wet adhesive and lubricant. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a glucuronolactone dispersible tablet and a preparation method thereof. Background technique [0002] Glucurolactone was synthesized by Stacey in 1939, and its chemical structure was determined by Stanek in 1963. my country started production in 1959. Other names are Tylenol, Glucuronolactone, Glucuronate, Glucurone, Guronsan, Glycurone. The raw material glucuronolactone is white crystal or crystalline powder; odorless, slightly bitter taste, the color gradually darkens when exposed to light. Unstable in nature, easily soluble in water, slightly soluble in ethanol, slightly soluble in methanol. [0003] Glucuron lactone is a hepatoprotective drug that enhances the detoxification function of the liver. When liver cells are damaged, the detoxification function of the liver decreases, and glucuronolactone enters the body under the action of enzymes and becomes glucuronic acid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/20A61P1/16
Inventor 王国成张广明
Owner TASLY HLDG GRP CO LTD
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