Method for preparing 3D porous bracket of chitosan - copolymer of poly lactic acid
A polylactic acid copolymer, three-dimensional porous technology, applied in medical science, prosthesis, etc., to achieve the effect of strong connectivity, wide range of sources, and improved processing performance
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[0022] Example 1:
[0023] Weigh 1.5 g of chitosan, dissolve it in 2.25 g of DL-lactic acid, and stir for 0.5 hours until the dissolution is complete. Weigh 2.5g of sodium chloride and add it to this solution, stir mechanically for 3 hours, wait until the mixture is uniform, and heat at 50°C for 10 minutes. Pour the solution into a plastic mold, let it stand at room temperature for 24 hours, and then put it in an oven at 40° C. and dry it under normal pressure for 96 hours. In three steps, the dried and formed solid is heated and copolymerized under vacuum conditions:
[0024] ①40-50℃, 0.06MPa, heating for 1.5 hours
[0025] ②75-80℃, 0.08MPa, heating for 2-3 hours
[0026] ③85-95℃, 0.1MPa, heating for 2-3 hours
[0027] The removed solid was continuously extracted with 500 mL of methanol for 24 hours and then put into a vacuum drying oven, and further dried for 48 hours at room temperature and 0.1 MPa to remove the remaining methanol. Then the solid substance was soaked in deioniz...
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[0028] Example 2:
[0029] Weigh 1.5 g of chitosan, dissolve it in 6 g of L-lactic acid, and stir for 0.5 hours until the dissolution is complete. Weigh 2.5g of sodium chloride and add it to this solution, stir mechanically for 1 hour, wait until it is evenly mixed, and heat it at 50°C for 5 minutes. Pour the solution into a plastic mold, let it stand at room temperature for 24 hours, and then put it in an oven at 30°C for 96 hours at normal pressure. The vacuum copolymerization process is the same as above. The taken out stent was continuously extracted with 500 mL of methanol for 40 hours and then placed in a vacuum drying oven, and further dried for 48 hours at room temperature and 0.1 MPa to remove the remaining methanol. The stent was then immersed in deionized water, and the water was changed every 24 hours. After repeated cleaning for 14 times, the presence of sodium chloride was not detected in the deionized water after washing, and a wet stent was obtained. The wet scaffo...
Example Embodiment
[0030] Example 3:
[0031] Weigh 1.5 g of chitosan and dissolve it in 3 g of lactic acid, and stir for 1 hour until the dissolution is complete. Weigh 1.5g potassium chloride and add it to this solution, stir mechanically for 3 hours, wait until it is uniformly mixed, and heat it at 40°C for 10 minutes. Pour the solution into a plastic petri dish, let it stand at room temperature for 12 hours, and then put it in an oven at 60°C and dry it under normal pressure for 36 hours. The vacuum copolymerization process is the same as above. The taken out stent was continuously extracted with 500 mL of methanol for 40 hours and then put into a vacuum drying oven, and further dried for 48 hours at room temperature and 0.08 MPa to remove the remaining methanol. Then the stent was immersed in deionized water, and the water was changed every 24 hours. After repeated cleaning for 14 times, the presence of potassium chloride in the deionized water after washing was not detected, and a wet stent wa...
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