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An antitumor compound pharmaceutical composition with barbed stullcap and preparation process thereof

A composition and technology of bark lotus, applied in the field of medicine, can solve the problems of difficult to accept treatment, damage to heart function, unable to fundamentally prevent the regeneration and reproduction of cancer cells and the like

Inactive Publication Date: 2007-05-16
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although surgery can remove the primary lesion, it cannot fundamentally prevent the regeneration and reproduction of cancer cells, which is the root cause of cancer recurrence and metastasis in the future; although radiotherapy and chemotherapy can kill cancer cells, they also make a large number of normal cells. Damage to tissue cells can induce gastrointestinal reactions, bone marrow suppression, and damage to liver, kidney, and heart functions, making the patient weaker and difficult to receive further treatment

Method used

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  • An antitumor compound pharmaceutical composition with barbed stullcap and preparation process thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] The preparation of embodiment 1 Scutellaria barbata extract

[0144] The preparation method of Scutellaria barbata extract

[0145] Take Scutellaria barbata medicinal material, add 75% ethanol to extract twice, each time 2h, add alcohol 10 times the amount, combine the decoction, filter, the ethanol is recovered from the filtrate until it has no alcohol smell, add to the treated polyamide column (100g , 30-60 mesh, column inner diameter 3mm, wet packed with ethanol, pre-washed with an appropriate amount of ethanol, and then washed with water until there is no alcohol smell, set aside), first rinse with 2 times the column volume of water, and then use 2 times the column volume of Rinse with 10% ethanol, discard the rinse solution, and then elute with 3 times column volume of 70% ethanol, collect the eluate, recover the ethanol and concentrate to a concentrated solution with a relative density of 1.05-1.11, and spray dry to obtain the product.

[0146] Determination of...

Embodiment 2

[0159] The preparation of embodiment 2 lobelia extract

[0160] Preparation process of lobelia extract:

[0161] Take lobelia medicinal material, decoct twice with water, add 12 times the amount of water for the first 2 hours, add 10 times the amount of water for the second 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.14~1.19 (55~ 60°C), add ethanol to make the alcohol content reach 60%, let stand for 24 hours, filter, recover ethanol until there is no alcohol smell, add ethanol to make the alcohol content reach 80%, let stand for 24 hours, filter , recover ethanol until there is no alcohol smell, concentrate under reduced pressure to a relative density of 1.09-1.12, and spray dry.

[0162] Identification of Lobelia Extract

[0163] Take 100 mg of this product, add 30 ml of methanol, sonicate for 30 minutes, let cool, filter, evaporate the filtrate to dryness, add 1 ml of methanol to dissolve the residue, and use it as the ...

Embodiment 3

[0167] The preparation of embodiment 3 Lobelia and Scutellaria barbata mixed extract

[0168] Preparation process of Lobelia and Scutellaria barbata mixed extract:

[0169]Take 25kg of Lobelia and Scutellaria barbata, add water to extract three times, add 12 times the amount of water for the first 2 hours, add 10 times the amount of water for the second and third 1 hour, combine the decoction and filter, and concentrate the filtrate to relative density 1.05-1.08, add ethanol to make the alcohol content 65%, let it stand for 24 hours, filter, adjust the pH value of the filtrate to 8.0-8.5, let it stand for 1 hour, filter, recover the ethanol from the filtrate until it has no alcohol smell, add ethanol Make the alcohol content to 85%, refrigerate for 24 hours, filter, recover ethanol from the filtrate until it has no alcohol smell, concentrate under reduced pressure to a thick paste with a relative density of 1.19-1.26, and spray dry to obtain.

[0170] Identification of Lobe...

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Abstract

The invention belongs to the field of pharmacy, and discloses a pharmaceutical composition mainly used for antineoplastic actions, the process for preparation and use thereof, wherein the composition comprises (by weight ratio) barbat skullcap 200-4000 parts, radical lobelia 200-4000 parts or corresponding weight parts of extract. The composition can also include 100-2400 parts of flavescent sophora root extract and can be prepared into any of the pharmacologically acceptable dose forms.

Description

1. Technical field [0001] The invention relates to a compound medicinal composition made of barbata and lobelia, or barbata, lobelia and matrine, and provides a preparation method thereof, which belongs to the technical field of medicine. 2. Background technology [0002] Tumors, especially malignant tumors (cancers), are a class of diseases that seriously threaten human life and health, and are malignant diseases with extremely high mortality rates. According to statistical reports, about 1 million cancer patients are newly discovered in my country every year, and cancer kills about 6 million people every year in the world, and puts 10 million people on the verge of death. With the deteriorating environment of human beings, the incidence of cancer is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of human beings in the 21st century. Conventional treatments for tumors include chemotherapy (chemotherapy), surgical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/75A61P35/00
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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