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Treating a tumor or the like with an electric field

An electric field and frequency technology, applied in the field of non-dividing cells, can solve the problems of damage to normal cells and tumor cells, and the ability to distinguish them.

Active Publication Date: 2010-09-01
ノボキュアゲーエムベーハー
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A disadvantage of this method is that its discriminatory power is highly dependent on cell type, e.g. the size difference between normal cells and tumor cells is only significant in specific cells
Another drawback of this method is that the applied voltage will damage some normal cells and may not damage all tumor cells since the size differences and membrane dielectric properties are mainly statistical and the actual cell geometry and dielectric properties vary widely

Method used

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  • Treating a tumor or the like with an electric field
  • Treating a tumor or the like with an electric field
  • Treating a tumor or the like with an electric field

Examples

Experimental program
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Embodiment approach

[0073] According to an exemplary embodiment of the present invention, the electric field used is an alternating electric field with a frequency ranging from about 50 KHz to about 500 KHz, preferably a frequency ranging from about 100 KHz to about 300 KHz. For ease of discussion, these types of fields are hereinafter also referred to as "TC fields", which is an abbreviation for "tumor therapy fields" because these fields fall within the biologically effective field characteristics without meaningful stimulating and thermal effects (intermediate between the high and low frequency ranges) intermediate category. These frequencies are low enough that the system behavior can be determined by the ohmic (conductive) properties of the system, but high enough not to have any stimulating effect on excitable tissue. Such a system consists of two types of components, namely, the intercellular, or intracellular fluid, or medium, and individual cells. The intercellular fluid is primarily an...

example

[0104] To demonstrate the effectiveness of an electric field having the above properties (eg, a frequency between 50 KHz and 500 KHz) in destroying tumor cells, mice bearing malignant melanoma tumors were treated with the electric field. Two pairs of isolects 230 were placed on a corresponding pair of melanomas. Only one pair was connected to the generator 210, and a 200 KHz alternating electric field (TC electric field) was applied to the tumor for 6 days. One melanoma was left untreated to allow a comparison between treated and non-treated tumors. After 6 days of treatment, pigmented melanomas were still clearly visible on the untreated side of the mice, while conversely, no tumors were seen on the treated side of the mice. The only discernible area on the skin is a marker representing the insertion site of isolects 230. The fact that the tumor on the treated side was eliminated was further confirmed by cutting and inverting the skin to expose the inner surface of the skin...

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Abstract

Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Improved results may be achieved by using a field with two or more frequencies.

Description

[0001] Cross References to Related Applications [0002] This application has the benefit of US Provisional Application 60 / 565,065, filed April 23, 2004, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates to the selective destruction of rapidly dividing cells in a localized area, and more particularly to the selective destruction of dividing cells without destroying nearby non-dividing cells by applying an electric field with specific characteristics to a target area of ​​a patient. Background technique [0004] All living things multiply by cell division, including cell cultures, microorganisms (such as bacteria, mycoplasma, yeast, protozoa, and other single-celled organisms), fungi, algae, plant cells, and the like. The division cells of these organisms can be destroyed, or the proliferation of these division cells can be controlled, by methods based on the sensitivity of the division cells of these organisms ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N1/40A61N1/00A61N1/32
CPCA61N1/326A61N1/40
Inventor Y·帕尔蒂
Owner ノボキュアゲーエムベーハー