Methods and compositions using immune regulative compound for treatment and management of cancers and other diseases

A compound and solvate technology, applied in the field of pharmaceutical composition and dosage regimen, can solve the problems of severe nausea, myelosuppression and immunosuppression, drug resistance, toxic chemotherapy reagents, etc.

Inactive Publication Date: 2007-06-20
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Almost all chemotherapeutic agents are toxic, and chemotherapy can cause significant and often dangerous side effects, including severe nausea, myelosuppression, and immunosuppression
In addition, many tumor cells are resistant to, or develop resistance to, chemotherapeutic agents, even when combinations of chemotherapeutic agents are administered

Method used

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  • Methods and compositions using immune regulative compound for treatment and management of cancers and other diseases
  • Methods and compositions using immune regulative compound for treatment and management of cancers and other diseases
  • Methods and compositions using immune regulative compound for treatment and management of cancers and other diseases

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Embodiment Construction

[0023] The first embodiment of the present invention includes a method for treating, controlling or preventing cancer, the method comprising administering a therapeutically or prophylactically effective amount of an immunomodulatory compound of the present invention, or a pharmaceutically acceptable amount thereof, to a patient in need of such treatment or prevention. Salts, solvates, hydrates, stereoisomers, clathrates or prodrugs of .

[0024] In certain methods encompassed within this embodiment, the immunomodulatory compound is administered in combination with another drug ("second active agent") or method of treating, controlling or preventing cancer. Secondary active agents include small and large molecules (eg, proteins and antibodies), examples of which are given herein, and stem cells. Methods or therapies that can be used in conjunction with the administration of immunomodulatory compounds include, but are not limited to, surgery, blood transfusion, immunotherapy, bi...

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Abstract

Methods of treating, preventing and / or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Description

[0001] This application is a divisional application of Chinese patent application 03816899.5 submitted on January 17, 2005, and the filing date is May 16, 2003. This application claims the benefit of US Provisional Application 60 / 380,842, filed May 17, 2002, and US Provisional Application 60 / 424,600, filed November 6, 2002, respectively, which are hereby incorporated by reference in their entirety. 1. Field of invention [0002] The present invention relates to the treatment, prevention and / or management of certain cancers, and other diseases including, but not limited to, those associated with unwanted angiogenesis by administering one or more immunomodulatory compounds alone or in combination with other therapeutic agents A method of treating a disease of or characterized by it. In particular, the invention encompasses the use of specific combinations, or "cocktails", of drugs and other therapies such as radiation to treat these specific cancers, including those resistant to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61K31/40A61K31/454C07D401/00A61P35/00A61K45/00A61K31/00A61K31/198A61K31/4035A61K31/425A61K31/515A61K31/573A61K35/12A61K35/14A61K35/28A61K45/06A61K51/00A61P1/04A61P1/16A61P3/06A61P3/10A61P7/02A61P7/06A61P9/00A61P9/04A61P9/10A61P9/14A61P11/00A61P11/06A61P11/16A61P17/00A61P17/02A61P17/06A61P17/10A61P17/12A61P19/02A61P19/08A61P19/10A61P25/00A61P27/02A61P27/06A61P27/10A61P27/14A61P29/00A61P31/00A61P31/04A61P31/08A61P31/10A61P31/12A61P31/18A61P31/22A61P33/00A61P33/02A61P33/06A61P35/02A61P35/04A61P37/00A61P37/02A61P37/06A61P37/08A61P41/00A61P43/00C07D209/46C07D401/04C07J5/00
CPCA61K31/4035A61K31/425A61K31/445A61K31/454A61K31/515A61K45/06A61K31/40A61P1/04A61P1/16A61P11/00A61P11/06A61P11/16A61P17/00A61P17/02A61P17/06A61P17/10A61P17/12A61P19/02A61P19/08A61P19/10A61P25/00A61P25/28A61P25/32A61P27/02A61P27/06A61P27/10A61P27/14A61P29/00A61P31/00A61P31/04A61P31/08A61P31/10A61P31/12A61P31/18A61P31/22A61P33/00A61P33/02A61P33/06A61P35/00A61P35/02A61P3/06A61P35/04A61P37/00A61P37/02A61P37/06A61P37/08A61P41/00A61P43/00A61P7/02A61P7/06A61P9/00A61P9/04A61P9/10A61P9/14A61P3/10Y02A50/30A61K2300/00
Inventor J·B·泽尔迪斯
Owner CELGENE CORP
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