13 results about "Immuno therapy" patented technology

Aspects of the present disclosure are directed to methods and compositions for diagnosing and / or treating a subject having cancer. Certain aspects relate to treatment with a cancer therapy and a YTHDF2 inhibitor or a pharmaceutical composition comprising a cancer therapy and a YTHDF2 inhibitor. In some aspects, the YTHDF2 inhibitor includes an oligonucleotide targeting YTHDF2 mRNA or a small molecule inhibitor of YTHDF2. In some aspects, a subject has been determined to have or to have had resistance to a previous cancer treatment, such as radiotherapy and / or immunotherapy.

Methods for targeting a tumor antigen for immunotherapy based on HLA allele type and the mutations present in the tumor antigen are presented. A patient's HLA allele type and a tumor antigen derived from a mutation in cancer driver gene can be matched with a majority allele type having a minimum affinity to the same tumor antigen or with those of a plurality of patients with a history of cancer treatment. Upon matching, a cancer treatment against the tumor antigen can be selected and administered to the patient to achieve a desired effect.

The present invention relates to combinations of host cells expression antigen binding proteins that specifically bind to a tumor expressed Preferentially Expressed Antigen of Melanoma (PRAME) antigenic peptide in a complex with MHC, and mRNAs encoding PRAME antigenic peptides. The invention further relates to combined TCR-T / mRNA therapy employing said mRNAs and host cells. In particular, a combined TCR-T / mRNA therapy is provided for use in cancer treatment.

This invention provides compositions for drug delivery in cancer treatment and immunotherapy. [Solution] A composition is provided comprising polymer gelatin, silicate nanoparticles, and a therapeutic agent having a molecular weight of less than 1000 daltons, wherein the gelatin, the silicate nanoparticles, and the therapeutic agent form a shear-thinning hydrogel.

Provided are a combined therapy of photodynamic therapy and immunological therapy, comprising the combined administration of a porphyrin dimer salt-based photosensitizer and an immune checkpoint inhibitor, and the use thereof in treatment of recurrent and / or metastatic cancers, in particular esophageal cancer.

The present invention relates to a method for diagnosing whether anticancer therapy will exhibit responsiveness in a particular patient. The anticancer therapy may include chemotherapy or cancer immunotherapy. Specifically, whether anticancer therapy will exhibit responsiveness in a particular patient can be confirmed through a TCTP level in the plasma of the corresponding patient. In such an aspect, the present invention also relates to use of plasma TCTP as a biomarker indicative of responsiveness to anticancer therapy.

This invention relates to biomarkers for predicting the therapeutic responsiveness of cancer patients to immune checkpoint inhibitors. Since gene signatures and gene markers based on a specific pattern demonstrate significantly superior predictive power regarding the therapeutic responsiveness of cancer patients to immuno-anticancer drugs, it is possible to select patient groups predicted to show a therapeutic effect and perform appropriate treatment, thereby reducing patient suffering and costs.

An image depicting a tissue sample is received. One or more tissue compartments present in the image of the tissue sample are identified including by generating a compartment map identifying pixels in the image depicting the tissue compartments. One or more cells present in the image of the tissue sample are identified including by generating a cell map identifying pixels in the image depicting the cells. A density-based pathology signature for the image of the tissue sample is determined based on the compartment map and the cell map. The density-based pathology signature includes a density of each cell type present in the one or more tissue compartments. A response computation model is applied to determine, based on the density-based pathology signature, a predictive output indicative of a likelihood of a patient associated with the tissue sample responding to an anticancer therapy such as immunotherapy.

This invention relates to an oral immunotherapy (OIT) composition comprising granules that contain an allergenic protein, such as peanut protein, along with a humectant, such as trehalose, and a binder, such as hypromellose. The composition may further comprise a filler, such as mannitol and a lubricant, such as stearic acid. OIT compositions, methods of preparing OIT compositions and methods of treatment of food allergy using OIT compositions are provided.

Shear-thinning biomaterial technology offers enables polymers and drugs loaded inside such polymers to be easily delivered directly through catheters into target area for use, for example, in cancer therapy and immunotherapy. When a force above a certain threshold is applied to inject such materials, they “thin” and behaves as a semi-solid, allowing the material to readily flow through a catheter. When the force is removed, the material instantly becomes a soft solid with significant cohesive properties that prevent it from dislodging or breaking up. We have developed novel shear-thinning biomaterials using spherical silica nanoparticles and gelatin-based polymers. Rheological tests confirm that these materials have excellent shear-thinning properties and further have improved material properties (e.g. improved stability profiles) as compared conventional materials available to medical professionals.

The application provides a kind of drug composition in the preparation for the application of the drug for the maintenance treatment of disease control ES-SCLC after first-line chemotherapy, belong to the biomedicine technical field.The drug composition is carimab and apatinib.The application finds that carimab is combined with apatinib as maintenance treatment, shows encouraging efficacy and acceptable safety in ES-SCLC patient who is not in progress after first-line chemotherapy, the median overall survival (OS) is 25.00 months, and the 12-month OS rate is 71.4%.This strategy of simultaneously targeting PD-1 and VEGFR2 provides a novel and reasonable solution for extending the disease control period in malignant tumors with limited treatment options after induction therapy, not only solves the key needs of ES-SCLC patients for more effective maintenance treatment, but also provides important insights into the biological principles of anti-angiogenic therapy combined with immunotherapy.

A procedure for the destruction of cancer cells based on the use of magnetically coated nanoparticles (NPs), preferably coated with biocompatible molecules, which are taken up by cells through endocytosis or cell membrane transport proteins, and the application, preferably, of variable electromagnetic fields using device (1). These fields can be modified in frequency, intensity, and duration using a data input device (10), and these parameters are displayed using display devices (8) (9). This generates a magneto-mechanical process that agitates the nanoparticles inside the cell and causes their destruction, without the need for chemotherapy, radiotherapy, immunotherapies, heat treatments, surgery, or any other intervention. This procedure is applicable to any type of tumor, regardless of size, shape, or location in the body.