Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antineoplastic Chinese medicinal preparation

A traditional Chinese medicine preparation and anti-tumor technology, which is applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, drug delivery, etc. It can solve the problems of poor stability during storage, low content of active ingredients, and many impurities. Toxic and side effects, definite curative effect, convenient to use

Inactive Publication Date: 2007-06-20
国家中药制药工程技术研究中心 +1
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the clinical preparation of Brucea javanica only has two dosage forms of oral emulsion and intravenous injection oil emulsion, and the crude oil is mostly the crude extract of Brucea javanica, the content of active ingredients is low, and there are many impurities, which makes the preparation more difficult, the dosage of the preparation is large, and the storage Poor stability during the period, which brings many uncertain factors to the evaluation of the clinical promotion and use of Brucea javanica

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antineoplastic Chinese medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of supercritical extract of Brucea javanica

[0018] Weigh 5 kg of Brucea javanica coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and make the pressure of the extractor and the flow rate of carbon dioxide maintain at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, wherein the first step is extraction, extraction The pressure is 20MPa, the extraction temperature is 35°C, and the extraction flow rate is 4.8kg / m 2 s, the extraction time is 1 hour; in the second extraction step, add 4 times the amount of ethanol as the entrainer, the extraction pressure is 25MPa, the extraction temperature is 35°C, and the extraction flow rate is 4.8kg / m 2 s, the extraction time is 1 hour, the ethanol is recovered, and the two parts are combined to obtain a supercritical extract of Brucea javanica with good fluidity and darker color.

Embodiment 2

[0019] Embodiment 2: the preparation of supercritical extract of Brucea javanica

[0020] Weigh 5 kg of Brucea javanica coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and make the pressure of the extractor and the flow rate of carbon dioxide maintain at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, wherein the first step is extraction, extraction The pressure is 15MPa, the extraction temperature is 50°C, and the extraction flow rate is 0.6kg / m 2 s, the extraction time is 3 hours; in the second extraction step, add 5 times the amount of ethanol as the entrainer, the extraction pressure is 20MPa, the extraction temperature is 50°C, and the extraction flow rate is 1.2kg / m 2 s, the extraction time is 3 hours, the ethanol is recovered, and the two parts are combined to obtain a supercritical extract of Brucea javanica with good fluidity and darker color.

Embodiment 3

[0021] Embodiment 3: the preparation of supercritical extract of Brucea javanica

[0022] Weigh 5 kg of Brucea javanica coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and make the pressure of the extractor and the flow rate of carbon dioxide maintain at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, wherein the first step is extraction, extraction The pressure is 18MPa, the extraction temperature is 40°C, and the extraction flow rate is 1.8kg / m 2 .s, the extraction time is 1.5 hours; in the second extraction step, add 1 times the amount of ethanol as the entrainer, the extraction pressure is 23MPa, the extraction temperature is 45°C, and the extraction flow rate is 2.4kg / m 2 s, the extraction time is 2 hours, the ethanol is recovered, and the two parts are combined to obtain a supercritical extract of Brucea javanica with good fluidity and darker color.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

An antineoplastic Chinese medicine is mainly prepared from brucea fruit through supercritical extracting. It has high curative effect and high stability.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to an anti-tumor traditional Chinese medicine preparation. Background technique [0002] Brucea Jaranica L Merr is the dried ripe fruit of Brucea Jaranica L Merr. Harvest when the fruit is ripe in autumn, remove impurities and dry in the sun. Distributed in Taiwan, Fujian, Guangdong, Hainan, Guangxi, and Yunnan. Has heat-clearing and toxic substances removing. Cut off malaria, stop dysentery, corrode wart effect, be used for dysentery, malaria, treat wart externally, antitumor treatment. It has been reported in the literature that the alcohol extract of Brucea javanica has effects on human nasopharyngeal carcinoma cells KB, Walker-256 sarcoma and P 388 Lymphocytic leukemia has obvious inhibitory effect; javanica javanica oil has the effect on Ehrlich ascites carcinoma, ascites type liver cancer, S 37 , S 180 , u 14 have significant anticancer activity. Clinically...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/185A61K9/00A61P35/00
Inventor 刘志远阮克锋沈平孃张继全刘峻虞伟赵明
Owner 国家中药制药工程技术研究中心
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com