Antineoplastic Chinese medicinal preparation

A traditional Chinese medicine preparation and anti-tumor technology, which is applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, drug delivery, etc. It can solve the problems of poor stability during storage, low content of active ingredients, and many impurities. Toxic and side effects, definite curative effect, convenient to use

Inactive Publication Date: 2007-06-20
国家中药制药工程技术研究中心 +1
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  • Abstract
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  • Application Information

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Problems solved by technology

[0004] Since the clinical preparation of Brucea javanica only has two dosage forms of oral emulsion and intravenous injection oil emulsion, and the crude oil is mostly the crude extract of Brucea javanica, the content of active ingredients is low, and there ar

Method used

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  • Antineoplastic Chinese medicinal preparation

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Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of supercritical extract of Brucea javanica

[0018] Weigh 5 kg of Brucea javanica coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and make the pressure of the extractor and the flow rate of carbon dioxide maintain at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, wherein the first step is extraction, extraction The pressure is 20MPa, the extraction temperature is 35°C, and the extraction flow rate is 4.8kg / m 2 s, the extraction time is 1 hour; in the second extraction step, add 4 times the amount of ethanol as the entrainer, the extraction pressure is 25MPa, the extraction temperature is 35°C, and the extraction flow rate is 4.8kg / m 2 s, the extraction time is 1 hour, the ethanol is recovered, and the two parts are combined to obtain a supercritical extract of Brucea javanica with good fluidity and darker color.

Embodiment 2

[0019] Embodiment 2: the preparation of supercritical extract of Brucea javanica

[0020] Weigh 5 kg of Brucea javanica coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and make the pressure of the extractor and the flow rate of carbon dioxide maintain at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, wherein the first step is extraction, extraction The pressure is 15MPa, the extraction temperature is 50°C, and the extraction flow rate is 0.6kg / m 2 s, the extraction time is 3 hours; in the second extraction step, add 5 times the amount of ethanol as the entrainer, the extraction pressure is 20MPa, the extraction temperature is 50°C, and the extraction flow rate is 1.2kg / m 2 s, the extraction time is 3 hours, the ethanol is recovered, and the two parts are combined to obtain a supercritical extract of Brucea javanica with good fluidity and darker color.

Embodiment 3

[0021] Embodiment 3: the preparation of supercritical extract of Brucea javanica

[0022] Weigh 5 kg of Brucea javanica coarse powder, put it in the extractor, start the carbon dioxide high-pressure pump, and make the pressure of the extractor and the flow rate of carbon dioxide maintain at the set parameters through the joint adjustment of the back pressure valve and the high-pressure pump speed, wherein the first step is extraction, extraction The pressure is 18MPa, the extraction temperature is 40°C, and the extraction flow rate is 1.8kg / m 2 .s, the extraction time is 1.5 hours; in the second extraction step, add 1 times the amount of ethanol as the entrainer, the extraction pressure is 23MPa, the extraction temperature is 45°C, and the extraction flow rate is 2.4kg / m 2 s, the extraction time is 2 hours, the ethanol is recovered, and the two parts are combined to obtain a supercritical extract of Brucea javanica with good fluidity and darker color.

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Abstract

An antineoplastic Chinese medicine is mainly prepared from brucea fruit through supercritical extracting. It has high curative effect and high stability.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to an anti-tumor traditional Chinese medicine preparation. Background technique [0002] Brucea Jaranica L Merr is the dried ripe fruit of Brucea Jaranica L Merr. Harvest when the fruit is ripe in autumn, remove impurities and dry in the sun. Distributed in Taiwan, Fujian, Guangdong, Hainan, Guangxi, and Yunnan. Has heat-clearing and toxic substances removing. Cut off malaria, stop dysentery, corrode wart effect, be used for dysentery, malaria, treat wart externally, antitumor treatment. It has been reported in the literature that the alcohol extract of Brucea javanica has effects on human nasopharyngeal carcinoma cells KB, Walker-256 sarcoma and P 388 Lymphocytic leukemia has obvious inhibitory effect; javanica javanica oil has the effect on Ehrlich ascites carcinoma, ascites type liver cancer, S 37 , S 180 , u 14 have significant anticancer activity. Clinically...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/00A61P35/00
Inventor 刘志远阮克锋沈平孃张继全刘峻虞伟赵明
Owner 国家中药制药工程技术研究中心
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