Therapeutic action of intermittent hypoxia for treating myocardiac infarction

A technique for myocardial ischemia and oxygen, applied in the medical field

Inactive Publication Date: 2007-07-04
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether intermittent hypoxia can effectively improve the acute or subacute myocardial infarction that has occurred, that is, whether it has a palliative or therapeutic effect, has not been reported

Method used

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  • Therapeutic action of intermittent hypoxia for treating myocardiac infarction
  • Therapeutic action of intermittent hypoxia for treating myocardiac infarction
  • Therapeutic action of intermittent hypoxia for treating myocardiac infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] hypoxic system

[0034] A kind of oxygen chamber equipment for treating myocardial ischemia and infarction, said oxygen chamber equipment comprises a closed cabin body, said cabin body includes an oxygen supply device, an oxygen exhaust device, and an oxygen content detection device, Wherein, the oxygen supply device provides oxygen, and the oxygen discharge device can discharge oxygen.

[0035] The oxygen chamber can make the oxygen in it meet the following conditions: oxygen partial pressure Po 2 =84±20mmHg or 11.2±2.8kPa.

[0036] When in use, adjust the oxygen supply device to stabilize the partial pressure of oxygen in the oxygen chamber at Po 2 =84±1mmHg or 11.2±0.14kPa, put the mammal in it, and after maintaining it for an effective long time (such as 6 hours), turn off the oxygen supply device to keep the oxygen in the normal oxygen range (Po 2 =159mmHg±20mmHg (or 20.7kPa±3kPa)) hours. Repeat the above steps for 10-30 days to achieve the effect of treating o...

Embodiment 2

[0038] Animal grouping and animal model establishment

[0039] I. Grouping of animals

[0040] Male Sprague-Dawley rats (body weight 150-180 g) were all clean animals and were purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences. As shown in Figure 1, according to the requirements of the experimental design, the rats were randomly divided into groups.

[0041] After grouping, some of the rats underwent LADocclusion to cause acute myocardial infarction in the rats. The other part of rats was used as a sham operation group (Shamsurgery), and the coronary arteries were not ligated. The patients were closely observed for 7 days under normal temperature conditions after the operation. Rats were then randomly assigned to continue living in a normoxic environment or to be treated in a hypobaric oxygen chamber. The present inventor placed the rats after myocardial infarction in a hypobaric oxygen chamber for treatment for 14 days and 28 days, that is, af...

Embodiment 3

[0048] Effects of Intermittent Hypoxia on Physiological Parameters in Rats

[0049] Measuring blood parameter indicators

[0050] 21 days and 35 days after the myocardial infarction operation (that is, postoperative normoxia or intermittent hypoxia treatment for 14 days and 28 days), after the rats were anesthetized, 1ml of blood was collected from the inguinal artery, and the peripheral blood hemoglobin concentration was measured respectively. , red blood cell count and white blood cell count.

[0051] The results, body weight, arterial blood pressure, hemoglobin and red blood cell count values ​​of rats in each group are shown in Table 1. On the 7th day after operation, the arterial blood pressure of rats in the four groups was basically the same. After myocardial infarction surgery, intermittent hypoxia was treated for 14 days, and 28 days later, it was found that the blood pressure of rats in the MI-IH group was higher than that of the normoxia group (MI-Nor). =142.8±1....

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Abstract

The invention discloses a novel use of low-oxygen system used for the treatment of myocardial ischemia and myocardial infarction. The invention also discloses the application of oxygen in the manufacture of myocardial ischemia and myocardial infarction treatment equipments. The invention also discloses a method of treating mammal's myocardial ischemia and myocardial infarction using intermittent low oxygen dealing to carrying out treatment. The invention proves that the intermittent low oxygen dealing has significant therapeutic effect for big mouse myocardial ischemia and myocardial infarction; it provides new approach for clinical therapeutic of myocardial ischemia and myocardial infarction as a new interfere therapeutic means.

Description

technical field [0001] The invention belongs to the medical field and relates to the application of intermittent hypoxia in the treatment of myocardial infarction. Background technique [0002] Oxygen is a necessary condition for human beings and most organisms to survive, and it is also an important factor in the regulation of physiological functions of the body. Hypoxia is the basic environment for life development. Human embryos develop in a hypoxic environment, and some tissues are still in a hypoxic environment after birth. Therefore, the study of hypoxia involves the basic issues of life sciences, and the study of hypoxia and the damage and protection of human tissues, organs and cells has important medical value. [0003] As we all know, with the aggravation of ischemia and the expansion of infarct size, the damage to human body caused by myocardial infarction develops progressively. According to the World Health Organization, acute coronary artery obstruction is th...

Claims

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Application Information

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IPC IPC(8): A61G10/00A61G10/02A61G99/00A61K9/10
Inventor 杨黄恬周兆年许伟青朱仪
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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