Compound transdermal drug-delivery preparation for preventing intoxication of organophosphorus ester compound

A technology of organophosphate esters and compounds, applied in the field of medicine, to achieve the effect of preventing organophosphate poisoning, protecting life safety, and facilitating protective measures

Inactive Publication Date: 2010-05-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on its use in the treatment or prevention of organophosphorus pesticide poisoning

Method used

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  • Compound transdermal drug-delivery preparation for preventing intoxication of organophosphorus ester compound
  • Compound transdermal drug-delivery preparation for preventing intoxication of organophosphorus ester compound
  • Compound transdermal drug-delivery preparation for preventing intoxication of organophosphorus ester compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1. The preventive effect of galantamine and scopolamine compound on dichlorvos inhibiting the activity of cholinesterase in whole blood

[0024] Because the disc method commonly used in clinical monitoring of cholinesterase activity is to measure the activity of whole blood cholinesterase, we choose to measure the activity of whole blood cholinesterase.

[0025] 1. Prepare compound solution

[0026] 1). Prepare scopolamine solution

[0027] Add 75 μl of scopolamine DMSO mother solution (100 μg / μl) and 2925 μl of physiological saline and mix to obtain solution 4-0 (250 μg / ml). Take 1000 μl of solution 4-0 and add 2000 μl of normal saline and mix to obtain solution 3-0 (83.3 μg / ml). Take 1000 μl of solution 3-0 and add 2000 μl of physiological saline and mix to obtain solution 2-0 (27.8 μg / ml). Take 1000 μl of solution 2-0 and add 2000 μl of physiological saline and mix to obtain solution 1-0 (9.3 μg / ml).

[0028] 2). Preparation of galantamine solution

[0029...

Embodiment 2

[0045] Example 2. The preventive effect of galantamine and scopolamine compound on dichlorvos poisoning in mice

[0046] 1. Experimental animals: Kunming white mice (provided by the Experimental Animal Center of the Second Military Medical University), weighing 20-22 g, half male and half male.

[0047] 2. Grouping of animals: blank control group, model control group, and six preventive administration groups.

[0048] 3. Liquid preparation

[0049] Dissolve 25mg of galantamine in 10ml of normal saline to obtain No. 01 medicinal solution, take 1ml of No. 01 medicinal solution and add 9ml of normal saline to obtain No. 02 medicinal solution, take 1ml of No. 02 medicinal solution and add 9ml of normal saline to obtain No. 03 medicinal solution;

[0050] Dissolve 285 mg of scopolamine in 7.5 ml of normal saline to obtain No. 10 medicinal solution, take 0.8 ml of No. 10 medicinal solution and add 7.2 ml of normal saline to obtain No. 20 medicinal solution;

[0051] No. 01 drug so...

Embodiment 3

[0063] Embodiment 3. Scopolamine and galantamine compound in vitro transdermal experiment

[0064] 1. Prepare mixed liquid medicine

[0065] Dissolve 25 mg of galantamine in 20 ml of pH6.8 phosphate buffered saline (PBS), and 380 mg of scopolamine in 20 ml of pH6.8 PBS for later use.

[0066] 2. Skin treatment

[0067] Two male SD rats (provided by the Experimental Animal Center of the Second Military Medical University), weighing 200-220 g, were depilated with depilatory cream on the abdomen, and killed by neck dislocation 24 hours later. The skin of a mouse was cut into six pieces, washed with normal saline for later use.

[0068] 3. Installation of transdermal experimental pool

[0069] The transdermal machine was set at 34°C, and the horizontal transdermal diffusion cells were numbered 1 to 12. Star-shaped magnetic stirrers were installed in each cell, and the test stirrers all rotated well. Cells 1 to 6 corresponded to the six skins of rat No. 1. ~ Pool No. 12 corresp...

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PUM

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Abstract

The invention relates to a composite dermal agent which can prevent organic phosphate composite toxic reaction, wherein it comprises Bab paste and adhesive; it comprises galantamin, relative hydrobromate, hyoscine and relative hydrobromate; the content of hyoscine or relative hydrobromate is 0.005mg-8mg / cm2; the content of galantamin or relative hydrobromate is 0.007mg-10mg / cm2; the feeding area is 2. 5-70cm2. The external choline esterase activity test has proves its effect. The invention can prevent the toxic reaction of atgard.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a compound transdermal administration preparation composed of galantamine and scopolamine, which can prevent the poisoning of organophosphate compounds. Background technique [0002] Organophosphorus pesticides are the most widely used insecticides in my country at present, and there are dozens of commonly used ones. Due to its many varieties, good insecticidal performance, and low residues in crops, it plays an important role in agricultural production. The "2005-2006 China Pesticide Market Analysis and Investment Consulting Report" issued by China Investment and Consulting Network pointed out that dichlorvos and other six The amount of organophosphorus pesticides is still more than 10,000 tons. However, it has certain toxicity to humans and animals, and it is prone to poisoning when it is not properly kept, used carelessly, and not strictly protected. It is the main chemical that cause...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/55A61K9/70A61K47/38A61P39/02A61M37/00A61K31/46
Inventor 胡晋红朱全刚刘艳霞
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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