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Methods and compositions to inhibit tolerance to opioids

a technology of opioid tolerance and composition, applied in the direction of drug compositions, heterocyclic compound active ingredients, anhydride/acid/halide active ingredients, etc., can solve the problems of addiction and the extremely difficult treatment of opioid-induced hyperalgesia, and achieve the effect of inhibiting tolerance to opioids

Active Publication Date: 2021-09-28
SEN JAM PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about methods to prevent people from becoming addicted to opioids. These methods involve giving a pharmaceutical composition containing an NSAID and a co-agent like fexofenadine or ketotifen. Ibuprofen and fexofenadine are examples of NSAIDs and co-agents that can be used in the pharmaceutical composition. The combination of the NSAID and the co-agent can help reduce the likelihood of resistance to opioids. The pharmaceutical composition can be made into a tablet, lozenge, or chewing gum form for easy consumption.

Problems solved by technology

Opioids are powerful pain relievers, but their use is hindered by tolerance to the analgesic effects, physical dependence resulting in withdrawal syndrome, and the possibility of addiction.
Opioid-induced hyperalgesia is extremely difficult to treat.

Method used

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Examples

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Embodiment Construction

[0010]In one embodiment, the present invention is directed to methods of inhibiting the tolerance to opioids in human subjects. The methods include the administration of particular pharmaceutical compositions.

[0011]Throughout this specification, quantities are defined by ranges, and by lower and upper boundaries of ranges. Each lower boundary can be combined with each upper boundary to define a range. The lower and upper boundaries should each be taken as a separate element.

[0012]Opioids are substances that act by binding to opioid receptors, which receptors are found principally in the central and peripheral nervous system and the gastrointestinal tract. These receptors mediate both the psychoactive and the somatic effects of opioids. Medically opioids are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea and suppressing cough.

[0013]Opioids include opiates, which are alkaloid compounds naturally found in the opium poppy plant (...

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Abstract

The present invention provides a method of inhibiting tolerance to an opioid by a human subject in need thereof. The method comprises administering an effective amount of a pharmaceutical composition to the subject during opioid therapy. The pharmaceutical composition comprises a) a non-steroidal anti-inflammatory drug (NSAID); and b) a co-agent selected from the group consisting of: fexofenadine, ketotifen, desloratadine, cetirizine, salts thereof and combinations thereof.

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods, and compositions, for inhibiting the tolerance to opioids upon opioid therapy.BACKGROUND OF THE INVENTION[0002]Opioids are a class of drugs that include the illegal drug heroin and analgesics available legally by prescription, such as oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine and morphine. Opioids are powerful pain relievers, but their use is hindered by tolerance to the analgesic effects, physical dependence resulting in withdrawal syndrome, and the possibility of addiction.[0003]Tolerance is the need for progressively higher doses of an opioid in order to maintain the same therapeutic effect, e.g., same reduction in pain. Tolerance typically develops upon sustained opioid therapy. While opioid rotation is currently used to minimize tolerance, this approach requires close monitoring due to variable cross-tolerance and side effect profiles among different patients (Fine, P., J Pain Palliat Care Pharm...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K31/19A61K31/4535A61P25/30A61P25/36A61K31/192A61K31/445
CPCA61K31/192A61K31/445A61K31/4535
Inventor IVERSEN, JACQUELINEDAHL, THOMAS A.
Owner SEN JAM PHARMA LLC
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